ES2175940T3 - Formulacion farmaceutica de un compuesto didemnina. - Google Patents
Formulacion farmaceutica de un compuesto didemnina.Info
- Publication number
- ES2175940T3 ES2175940T3 ES99905091T ES99905091T ES2175940T3 ES 2175940 T3 ES2175940 T3 ES 2175940T3 ES 99905091 T ES99905091 T ES 99905091T ES 99905091 T ES99905091 T ES 99905091T ES 2175940 T3 ES2175940 T3 ES 2175940T3
- Authority
- ES
- Spain
- Prior art keywords
- compound
- didemnine
- pharmaceutical formulation
- didemnin
- lyophilized
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Abstract
Una composición farmacéutica de un compuesto de didemnina que comprende en primer lugar una preparación liolizada de didemnina incluyendo un producto soluble en agua y en segundo lugar una solución de reconstitución de una mezcla de disolventes.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9803448.1A GB9803448D0 (en) | 1998-02-18 | 1998-02-18 | Pharmaceutical formulation |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2175940T3 true ES2175940T3 (es) | 2002-11-16 |
Family
ID=10827213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES99905091T Expired - Lifetime ES2175940T3 (es) | 1998-02-18 | 1999-02-18 | Formulacion farmaceutica de un compuesto didemnina. |
Country Status (17)
Country | Link |
---|---|
US (1) | US8420130B1 (es) |
EP (1) | EP1054686B1 (es) |
JP (2) | JP4536255B2 (es) |
KR (1) | KR100595597B1 (es) |
CN (1) | CN1170586C (es) |
AT (1) | ATE217532T1 (es) |
AU (1) | AU754073B2 (es) |
BR (1) | BRPI9908088C1 (es) |
CA (1) | CA2321116C (es) |
DE (1) | DE69901487T2 (es) |
DK (1) | DK1054686T3 (es) |
ES (1) | ES2175940T3 (es) |
GB (1) | GB9803448D0 (es) |
HK (1) | HK1032538A1 (es) |
IL (1) | IL137911A (es) |
PT (1) | PT1054686E (es) |
WO (1) | WO1999042125A1 (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030148933A1 (en) | 1990-10-01 | 2003-08-07 | Pharma Mar S.A. | Derivatives of dehydrodidemnin B |
GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
GB0002952D0 (en) | 2000-02-09 | 2000-03-29 | Pharma Mar Sa | Process for producing kahalalide F compounds |
DE10008128A1 (de) * | 2000-02-22 | 2001-08-23 | Bayer Ag | Endoparasitizide Mittel |
UA76718C2 (uk) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
BR0114604A (pt) | 2000-10-12 | 2003-10-14 | Pharma Mar Sa | Tratamento de cnceres |
CN1568192A (zh) * | 2000-10-31 | 2005-01-19 | 法马马有限公司 | KahalalideF制剂 |
GB0304367D0 (en) | 2003-02-26 | 2003-04-02 | Pharma Mar Sau | Methods for treating psoriasis |
US7507708B2 (en) | 2003-02-26 | 2009-03-24 | Pharma Mar, S.A.U. | Antitumoral compounds |
AU2004218883B2 (en) * | 2003-03-12 | 2009-10-01 | Dana-Farber Cancer Institute, Inc. | Aplidine for multiple myeloma treatment |
KR20060002778A (ko) * | 2003-03-12 | 2006-01-09 | 파르마 마르, 에스.에이. | 개선된 항종양 치료 |
US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
CN100335495C (zh) * | 2006-01-23 | 2007-09-05 | 南方医科大学 | 一种海鞘多肽及其制备方法 |
ES2575518T3 (es) | 2006-02-28 | 2016-06-29 | Pharma Mar S.A. | Tratamiento mejorado de mieloma múltiple |
AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
AU2012214419B2 (en) | 2011-02-09 | 2015-12-24 | Glaxosmithkline Llc | Lyophilized formulations |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
JP2023517194A (ja) | 2020-03-02 | 2023-04-24 | ファルマ、マール、ソシエダード、アノニマ | コロナウイルス感染の処置における組合せに使用するためのpld |
US20230158104A1 (en) | 2020-03-02 | 2023-05-25 | Pharma Mar, S.A. | Compounds for use in autoimmune conditions |
AU2021232534A1 (en) | 2020-03-02 | 2022-10-06 | Pharma Mar, S.A. | Compounds for use in the treatment of coronavirus infection |
AU2021231197A1 (en) | 2020-03-02 | 2022-10-06 | Pharma Mar, S.A. | Compounds for use in inflammatory conditions |
CN114085272B (zh) * | 2022-01-10 | 2022-06-10 | 中山大学 | 一种isaridin类环酯肽衍生物及其制备方法和应用 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4342744A (en) * | 1979-07-19 | 1982-08-03 | Lever Brothers Company | Hair treatment products |
EP0048149B1 (en) * | 1980-09-12 | 1983-11-30 | University of Illinois Foundation | Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them |
US4493796A (en) | 1980-09-12 | 1985-01-15 | Board Of Trustees, Univ. Of Ill. | Didemnins A, B, C, and derivatives thereof, as antiviral agents |
JPS5781413A (en) * | 1980-09-12 | 1982-05-21 | Univ Illinois | Didemnin antibiotic |
US4950649A (en) * | 1980-09-12 | 1990-08-21 | University Of Illinois | Didemnins and nordidemnins |
IT1153974B (it) | 1982-09-23 | 1987-01-21 | Erba Farmitalia | Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento |
US4948791A (en) | 1989-04-10 | 1990-08-14 | The Board Of Trustees Of The University Of Illinois | Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum |
GB8922026D0 (en) | 1989-09-29 | 1989-11-15 | Pharma Mar Sa | Novel anti-viral and cytotoxic agent |
DE4120327A1 (de) | 1991-06-20 | 1992-12-24 | Basf Ag | Neue peptide, ihre herstellung und verwendung |
FR2698543B1 (fr) * | 1992-12-02 | 1994-12-30 | Rhone Poulenc Rorer Sa | Nouvelles compositions à base de taxoides. |
IL109350A (en) * | 1993-05-12 | 2001-01-28 | Genentech Inc | Stable liquid preparations of gamma interferon |
US5462726A (en) | 1993-12-17 | 1995-10-31 | Bristol-Myers Squibb Company | Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents |
ATE220894T1 (de) * | 1993-12-29 | 2002-08-15 | Matrix Pharma | Zusammensetzung für lokale freigabe von zytostatika |
US5861439A (en) * | 1994-11-14 | 1999-01-19 | Alza Corporation | Method for enhanced electrotransport agent delivery |
ES2102322B1 (es) | 1995-07-13 | 1998-03-01 | Pharma Mar Sa | Procedimiento de preparacion de didemnina a. |
US6365597B1 (en) * | 1996-02-14 | 2002-04-02 | Aventis Pharmaceuticals Inc. | 4-aza steroids |
US20020077461A1 (en) * | 1996-04-24 | 2002-06-20 | Soren Bjorn | Pharmaceutical formulation |
ES2151277T3 (es) | 1996-05-22 | 2000-12-16 | Protarga Inc | Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere. |
US6156724A (en) | 1996-06-07 | 2000-12-05 | Rinehart; Kenneth L. | Uses of didemnins as immunomodulating agents |
ES2135359T3 (es) | 1996-07-03 | 2002-05-16 | Paxton C G Ltd | Recipientes. |
JP2001503746A (ja) | 1996-10-24 | 2001-03-21 | ザ・ボード・オブ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・イリノイ | ジデムニン類似体の半合成法 |
DE69723728T2 (de) | 1996-10-24 | 2004-06-03 | The Board Of Trustees For The University Of Illinois, Urbana | Totalsynthese des amino hip analogen von didemnin a |
US6034058A (en) | 1997-04-15 | 2000-03-07 | Rinehart; Kenneth L. | Semi-synthetic alanyl dilemnin analogs |
DE69840497D1 (de) | 1997-05-07 | 2009-03-12 | William J Crumb | Verwendung von Aplidine zur Behandlung von kardiovaskulären Erkrankungen |
GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
DE69923322T2 (de) | 1998-07-30 | 2005-12-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Verwendung von propionyl-l-carnitin und acetyl-l-carnitin zur herstellung von arzneimittel mit antikrebs wirkung |
US20010021380A1 (en) | 1999-04-19 | 2001-09-13 | Pluenneke John D. | Soluble tumor necrosis factor receptor treatment of medical disorders |
WO2000071135A1 (en) | 1999-05-25 | 2000-11-30 | Point Therapeutics, Inc. | Anti-tumor comprising boroproline compounds |
US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
ATE363910T1 (de) | 1999-11-15 | 2007-06-15 | Pharma Mar Sa | Behandlung von krebserkrankungen durch aplidin |
US6509315B1 (en) | 2000-04-07 | 2003-01-21 | The Trustees Of The University Of Pennsylvania | Didemnin analogs and fragments and methods of making and using them |
WO2001076616A1 (en) | 2000-04-07 | 2001-10-18 | The Trustees Of The University Of Pennsylvania | Tamandarin and didemnin analogs and methods of making and using them |
UA76718C2 (uk) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
AU2002213053B2 (en) | 2000-10-05 | 2006-12-21 | Immunex Corporation | Nectin polypeptides, polynucleotides, methods of making and use thereof |
AU9402401A (en) | 2000-10-12 | 2002-04-22 | Pharma Mar Sa | Treatment of cancers |
AU2002224417A1 (en) | 2000-10-18 | 2002-04-29 | Immunex Corporation | Methods for treating il-18 mediated disorders |
PT1435991E (pt) | 2001-10-19 | 2009-01-16 | Pharma Mar Sa | Utilização de aplidina para o tratamento de cancro pancreático |
KR20060002778A (ko) | 2003-03-12 | 2006-01-09 | 파르마 마르, 에스.에이. | 개선된 항종양 치료 |
-
1998
- 1998-02-18 GB GBGB9803448.1A patent/GB9803448D0/en not_active Ceased
-
1999
- 1999-02-18 ES ES99905091T patent/ES2175940T3/es not_active Expired - Lifetime
- 1999-02-18 US US09/622,433 patent/US8420130B1/en not_active Expired - Fee Related
- 1999-02-18 EP EP99905091A patent/EP1054686B1/en not_active Expired - Lifetime
- 1999-02-18 CN CNB998050393A patent/CN1170586C/zh not_active Expired - Lifetime
- 1999-02-18 WO PCT/GB1999/000511 patent/WO1999042125A1/en active IP Right Grant
- 1999-02-18 PT PT99905091T patent/PT1054686E/pt unknown
- 1999-02-18 AT AT99905091T patent/ATE217532T1/de active
- 1999-02-18 DK DK99905091T patent/DK1054686T3/da active
- 1999-02-18 JP JP2000532139A patent/JP4536255B2/ja not_active Expired - Lifetime
- 1999-02-18 IL IL137911A patent/IL137911A/en not_active IP Right Cessation
- 1999-02-18 AU AU25389/99A patent/AU754073B2/en not_active Expired
- 1999-02-18 CA CA002321116A patent/CA2321116C/en not_active Expired - Lifetime
- 1999-02-18 KR KR1020007009012A patent/KR100595597B1/ko not_active IP Right Cessation
- 1999-02-18 DE DE69901487T patent/DE69901487T2/de not_active Expired - Lifetime
- 1999-02-18 BR BRPI9908088A patent/BRPI9908088C1/pt not_active IP Right Cessation
-
2001
- 2001-05-07 HK HK01103194A patent/HK1032538A1/xx not_active IP Right Cessation
-
2010
- 2010-03-08 JP JP2010050393A patent/JP2010163443A/ja not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR100595597B1 (ko) | 2006-07-03 |
BR9908088B1 (pt) | 2013-05-21 |
KR20010040993A (ko) | 2001-05-15 |
BRPI9908088B8 (pt) | 2017-03-07 |
WO1999042125A1 (en) | 1999-08-26 |
JP4536255B2 (ja) | 2010-09-01 |
DK1054686T3 (da) | 2002-06-17 |
EP1054686B1 (en) | 2002-05-15 |
AU754073B2 (en) | 2002-11-07 |
DE69901487T2 (de) | 2002-12-19 |
DE69901487D1 (de) | 2002-06-20 |
CA2321116A1 (en) | 1999-08-26 |
JP2010163443A (ja) | 2010-07-29 |
AU2538999A (en) | 1999-09-06 |
IL137911A (en) | 2006-04-10 |
CN1330551A (zh) | 2002-01-09 |
EP1054686A1 (en) | 2000-11-29 |
PT1054686E (pt) | 2002-09-30 |
IL137911A0 (en) | 2001-10-31 |
US8420130B1 (en) | 2013-04-16 |
CA2321116C (en) | 2009-10-06 |
BR9908088A (pt) | 2000-10-31 |
HK1032538A1 (en) | 2001-07-27 |
JP2002503704A (ja) | 2002-02-05 |
BRPI9908088C1 (pt) | 2021-05-25 |
ATE217532T1 (de) | 2002-06-15 |
CN1170586C (zh) | 2004-10-13 |
GB9803448D0 (en) | 1998-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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