PT1435991E - Utilização de aplidina para o tratamento de cancro pancreático - Google Patents
Utilização de aplidina para o tratamento de cancro pancreático Download PDFInfo
- Publication number
- PT1435991E PT1435991E PT02770106T PT02770106T PT1435991E PT 1435991 E PT1435991 E PT 1435991E PT 02770106 T PT02770106 T PT 02770106T PT 02770106 T PT02770106 T PT 02770106T PT 1435991 E PT1435991 E PT 1435991E
- Authority
- PT
- Portugal
- Prior art keywords
- aplidine
- pancreatic cancer
- treatment
- cancer
- pancreas
- Prior art date
Links
- 206010061902 Pancreatic neoplasm Diseases 0.000 title abstract 3
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 title abstract 2
- 201000002528 pancreatic cancer Diseases 0.000 title abstract 2
- 208000008443 pancreatic carcinoma Diseases 0.000 title abstract 2
- UUSZLLQJYRSZIS-LXNNNBEUSA-N plitidepsin Chemical compound CN([C@H](CC(C)C)C(=O)N[C@@H]1C(=O)N[C@@H]([C@H](CC(=O)O[C@H](C(=O)[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N2CCC[C@H]2C(=O)N(C)[C@@H](CC=2C=CC(OC)=CC=2)C(=O)O[C@@H]1C)C(C)C)O)[C@@H](C)CC)C(=O)[C@@H]1CCCN1C(=O)C(C)=O UUSZLLQJYRSZIS-LXNNNBEUSA-N 0.000 title abstract 2
- 229950008499 plitidepsin Drugs 0.000 title abstract 2
- 108010049948 plitidepsin Proteins 0.000 title abstract 2
- 230000001394 metastastic effect Effects 0.000 abstract 1
- 206010061289 metastatic neoplasm Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34841201P | 2001-10-19 | 2001-10-19 | |
| GB0208624A GB0208624D0 (en) | 2002-04-15 | 2002-04-15 | Use of aplidine for the treatment of pancreatic cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT1435991E true PT1435991E (pt) | 2009-01-16 |
Family
ID=26247033
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT02770106T PT1435991E (pt) | 2001-10-19 | 2002-10-21 | Utilização de aplidina para o tratamento de cancro pancreático |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20050004012A1 (pt) |
| EP (1) | EP1435991B1 (pt) |
| AT (1) | ATE411036T1 (pt) |
| AU (1) | AU2002336206B2 (pt) |
| CA (1) | CA2462642A1 (pt) |
| DE (1) | DE60229414D1 (pt) |
| ES (1) | ES2315404T3 (pt) |
| PT (1) | PT1435991E (pt) |
| WO (1) | WO2003033013A1 (pt) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| CA2391502A1 (en) * | 1999-11-15 | 2001-05-25 | Pharma Mar S.A | Aplidine treatment of cancers |
| UA76718C2 (uk) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
| NZ525196A (en) | 2000-10-12 | 2004-09-24 | Pharma Mar S | Treatment of cancers by aplidine in conjunction with a myoprotector |
| ES2312979T3 (es) | 2003-03-12 | 2009-03-01 | Dana-Farber Cancer Institute, Inc. | Aplidina para el tratamiento de mieloma multiple. |
| NZ541634A (en) | 2003-03-12 | 2008-08-29 | Pharma Mar Sa | Improved antitumoral treatments |
| PL2029155T3 (pl) * | 2006-02-28 | 2016-09-30 | Ulepszony sposób leczenia szpiczaka mnogiego | |
| WO2008080956A1 (en) * | 2006-12-29 | 2008-07-10 | Pharma Mar, S.A. | Prognostic molecular markers for the cancer therapy with aplidine |
| CA2703024A1 (en) * | 2007-10-19 | 2009-04-23 | Giuseppe Longo Sorbello | Improved antitumoral treatments |
| RU2010140888A (ru) * | 2008-03-07 | 2012-04-20 | Фарма Мар, С.А. (Es) | Улучшенные противораковые терапии |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4342744A (en) * | 1979-07-19 | 1982-08-03 | Lever Brothers Company | Hair treatment products |
| US4493796A (en) * | 1980-09-12 | 1985-01-15 | Board Of Trustees, Univ. Of Ill. | Didemnins A, B, C, and derivatives thereof, as antiviral agents |
| US4950649A (en) * | 1980-09-12 | 1990-08-21 | University Of Illinois | Didemnins and nordidemnins |
| IT1153974B (it) * | 1982-09-23 | 1987-01-21 | Erba Farmitalia | Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento |
| GB8922026D0 (en) * | 1989-09-29 | 1989-11-15 | Pharma Mar Sa | Novel anti-viral and cytotoxic agent |
| FR2698543B1 (fr) * | 1992-12-02 | 1994-12-30 | Rhone Poulenc Rorer Sa | Nouvelles compositions à base de taxoides. |
| US5462726A (en) * | 1993-12-17 | 1995-10-31 | Bristol-Myers Squibb Company | Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents |
| CA2180260A1 (en) * | 1993-12-29 | 1995-07-06 | Dennis M. Brown | Methods and compositions for the treatment of a host with a cellular proliferative disease |
| US5861439A (en) * | 1994-11-14 | 1999-01-19 | Alza Corporation | Method for enhanced electrotransport agent delivery |
| US6365597B1 (en) * | 1996-02-14 | 2002-04-02 | Aventis Pharmaceuticals Inc. | 4-aza steroids |
| DE69703294T2 (de) * | 1996-05-22 | 2001-05-17 | Protarga Inc | Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten |
| US6156724A (en) * | 1996-06-07 | 2000-12-05 | Rinehart; Kenneth L. | Uses of didemnins as immunomodulating agents |
| US6034058A (en) * | 1997-04-15 | 2000-03-07 | Rinehart; Kenneth L. | Semi-synthetic alanyl dilemnin analogs |
| DE69840497D1 (de) * | 1997-05-07 | 2009-03-12 | William J Crumb | Verwendung von Aplidine zur Behandlung von kardiovaskulären Erkrankungen |
| EP1100589B1 (en) * | 1998-07-30 | 2005-01-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. | Use of propionyl l-carnitine and acetyl l-carnitine in the preparation of medicaments with anticancer activity |
| US20010021380A1 (en) * | 1999-04-19 | 2001-09-13 | Pluenneke John D. | Soluble tumor necrosis factor receptor treatment of medical disorders |
| US6890904B1 (en) * | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| CA2391502A1 (en) * | 1999-11-15 | 2001-05-25 | Pharma Mar S.A | Aplidine treatment of cancers |
| US6509315B1 (en) * | 2000-04-07 | 2003-01-21 | The Trustees Of The University Of Pennsylvania | Didemnin analogs and fragments and methods of making and using them |
| AU2002213053B2 (en) * | 2000-10-05 | 2006-12-21 | Immunex Corporation | Nectin polypeptides, polynucleotides, methods of making and use thereof |
| WO2002032374A2 (en) * | 2000-10-18 | 2002-04-25 | Immunex Corporation | Methods for treating il-18 mediated disorders |
-
2002
- 2002-10-21 CA CA002462642A patent/CA2462642A1/en not_active Abandoned
- 2002-10-21 US US10/492,659 patent/US20050004012A1/en not_active Abandoned
- 2002-10-21 WO PCT/GB2002/004816 patent/WO2003033013A1/en not_active Application Discontinuation
- 2002-10-21 AU AU2002336206A patent/AU2002336206B2/en not_active Ceased
- 2002-10-21 AT AT02770106T patent/ATE411036T1/de not_active IP Right Cessation
- 2002-10-21 EP EP02770106A patent/EP1435991B1/en not_active Expired - Lifetime
- 2002-10-21 PT PT02770106T patent/PT1435991E/pt unknown
- 2002-10-21 ES ES02770106T patent/ES2315404T3/es not_active Expired - Lifetime
- 2002-10-21 DE DE60229414T patent/DE60229414D1/de not_active Expired - Lifetime
-
2009
- 2009-10-23 US US12/604,900 patent/US20100041594A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20050004012A1 (en) | 2005-01-06 |
| ES2315404T3 (es) | 2009-04-01 |
| DE60229414D1 (de) | 2008-11-27 |
| ATE411036T1 (de) | 2008-10-15 |
| CA2462642A1 (en) | 2003-04-24 |
| EP1435991A1 (en) | 2004-07-14 |
| AU2002336206B2 (en) | 2007-11-29 |
| US20100041594A1 (en) | 2010-02-18 |
| EP1435991B1 (en) | 2008-10-15 |
| WO2003033013A1 (en) | 2003-04-24 |
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