BRPI9908088C1 - composição farmacêutica de aplidina e seu método de preparação. - Google Patents
composição farmacêutica de aplidina e seu método de preparação.Info
- Publication number
- BRPI9908088C1 BRPI9908088C1 BRPI9908088A BR9908088A BRPI9908088C1 BR PI9908088 C1 BRPI9908088 C1 BR PI9908088C1 BR PI9908088 A BRPI9908088 A BR PI9908088A BR 9908088 A BR9908088 A BR 9908088A BR PI9908088 C1 BRPI9908088 C1 BR PI9908088C1
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- preparation
- aplidine
- didemnin
- lyophilized
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/15—Depsipeptides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
Abstract
patente de invenção: <b>"formulação farmacêutica de um composto de didemnin"<d>. uma composição farmacêutica estável de um composto de didemnin, compreende em primeiro lugar uma preparação de didemnin liofilizada incluindo material solúvel em água e em segundo lugar uma solução de reconstituição de solventes mistos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9803448.1A GB9803448D0 (en) | 1998-02-18 | 1998-02-18 | Pharmaceutical formulation |
PCT/GB1999/000511 WO1999042125A1 (en) | 1998-02-18 | 1999-02-18 | Pharmaceutical formulation of a didemnin compound |
Publications (4)
Publication Number | Publication Date |
---|---|
BR9908088A BR9908088A (pt) | 2000-10-31 |
BR9908088B1 BR9908088B1 (pt) | 2013-05-21 |
BRPI9908088B8 BRPI9908088B8 (pt) | 2017-03-07 |
BRPI9908088C1 true BRPI9908088C1 (pt) | 2021-05-25 |
Family
ID=10827213
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI9908088A BRPI9908088C1 (pt) | 1998-02-18 | 1999-02-18 | composição farmacêutica de aplidina e seu método de preparação. |
Country Status (17)
Country | Link |
---|---|
US (1) | US8420130B1 (pt) |
EP (1) | EP1054686B1 (pt) |
JP (2) | JP4536255B2 (pt) |
KR (1) | KR100595597B1 (pt) |
CN (1) | CN1170586C (pt) |
AT (1) | ATE217532T1 (pt) |
AU (1) | AU754073B2 (pt) |
BR (1) | BRPI9908088C1 (pt) |
CA (1) | CA2321116C (pt) |
DE (1) | DE69901487T2 (pt) |
DK (1) | DK1054686T3 (pt) |
ES (1) | ES2175940T3 (pt) |
GB (1) | GB9803448D0 (pt) |
HK (1) | HK1032538A1 (pt) |
IL (1) | IL137911A (pt) |
PT (1) | PT1054686E (pt) |
WO (1) | WO1999042125A1 (pt) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030148933A1 (en) | 1990-10-01 | 2003-08-07 | Pharma Mar S.A. | Derivatives of dehydrodidemnin B |
GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
GB0002952D0 (en) | 2000-02-09 | 2000-03-29 | Pharma Mar Sa | Process for producing kahalalide F compounds |
DE10008128A1 (de) * | 2000-02-22 | 2001-08-23 | Bayer Ag | Endoparasitizide Mittel |
UA76718C2 (uk) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
BR0114604A (pt) | 2000-10-12 | 2003-10-14 | Pharma Mar Sa | Tratamento de cnceres |
CN1568192A (zh) * | 2000-10-31 | 2005-01-19 | 法马马有限公司 | KahalalideF制剂 |
GB0304367D0 (en) | 2003-02-26 | 2003-04-02 | Pharma Mar Sau | Methods for treating psoriasis |
US7507708B2 (en) | 2003-02-26 | 2009-03-24 | Pharma Mar, S.A.U. | Antitumoral compounds |
AU2004218883B2 (en) * | 2003-03-12 | 2009-10-01 | Dana-Farber Cancer Institute, Inc. | Aplidine for multiple myeloma treatment |
KR20060002778A (ko) * | 2003-03-12 | 2006-01-09 | 파르마 마르, 에스.에이. | 개선된 항종양 치료 |
US8436190B2 (en) | 2005-01-14 | 2013-05-07 | Cephalon, Inc. | Bendamustine pharmaceutical compositions |
CN100335495C (zh) * | 2006-01-23 | 2007-09-05 | 南方医科大学 | 一种海鞘多肽及其制备方法 |
ES2575518T3 (es) | 2006-02-28 | 2016-06-29 | Pharma Mar S.A. | Tratamiento mejorado de mieloma múltiple |
AR072777A1 (es) | 2008-03-26 | 2010-09-22 | Cephalon Inc | Formas solidas de clorhidrato de bendamustina |
AU2012214419B2 (en) | 2011-02-09 | 2015-12-24 | Glaxosmithkline Llc | Lyophilized formulations |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
JP2023517194A (ja) | 2020-03-02 | 2023-04-24 | ファルマ、マール、ソシエダード、アノニマ | コロナウイルス感染の処置における組合せに使用するためのpld |
US20230158104A1 (en) | 2020-03-02 | 2023-05-25 | Pharma Mar, S.A. | Compounds for use in autoimmune conditions |
AU2021232534A1 (en) | 2020-03-02 | 2022-10-06 | Pharma Mar, S.A. | Compounds for use in the treatment of coronavirus infection |
AU2021231197A1 (en) | 2020-03-02 | 2022-10-06 | Pharma Mar, S.A. | Compounds for use in inflammatory conditions |
CN114085272B (zh) * | 2022-01-10 | 2022-06-10 | 中山大学 | 一种isaridin类环酯肽衍生物及其制备方法和应用 |
Family Cites Families (38)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4342744A (en) * | 1979-07-19 | 1982-08-03 | Lever Brothers Company | Hair treatment products |
EP0048149B1 (en) * | 1980-09-12 | 1983-11-30 | University of Illinois Foundation | Novel antibiotics, derivatives thereof, processes for their extraction, and compositions containing them |
US4493796A (en) | 1980-09-12 | 1985-01-15 | Board Of Trustees, Univ. Of Ill. | Didemnins A, B, C, and derivatives thereof, as antiviral agents |
JPS5781413A (en) * | 1980-09-12 | 1982-05-21 | Univ Illinois | Didemnin antibiotic |
US4950649A (en) * | 1980-09-12 | 1990-08-21 | University Of Illinois | Didemnins and nordidemnins |
IT1153974B (it) | 1982-09-23 | 1987-01-21 | Erba Farmitalia | Composizioni farmacologiche a base di cisplatino e metodo per il loro ottenimento |
US4948791A (en) | 1989-04-10 | 1990-08-14 | The Board Of Trustees Of The University Of Illinois | Novel Cytotoxic cyclic depsipeptides from the tunicate trididemnum solidum |
GB8922026D0 (en) | 1989-09-29 | 1989-11-15 | Pharma Mar Sa | Novel anti-viral and cytotoxic agent |
DE4120327A1 (de) | 1991-06-20 | 1992-12-24 | Basf Ag | Neue peptide, ihre herstellung und verwendung |
FR2698543B1 (fr) * | 1992-12-02 | 1994-12-30 | Rhone Poulenc Rorer Sa | Nouvelles compositions à base de taxoides. |
IL109350A (en) * | 1993-05-12 | 2001-01-28 | Genentech Inc | Stable liquid preparations of gamma interferon |
US5462726A (en) | 1993-12-17 | 1995-10-31 | Bristol-Myers Squibb Company | Method of inhibiting side effects of solvents containing ricinoleic acid or castor oil or derivatives thereof employing a thromboxane A2 receptor antagonist and pharmaceutical compositions containing such solvents |
ATE220894T1 (de) * | 1993-12-29 | 2002-08-15 | Matrix Pharma | Zusammensetzung für lokale freigabe von zytostatika |
US5861439A (en) * | 1994-11-14 | 1999-01-19 | Alza Corporation | Method for enhanced electrotransport agent delivery |
ES2102322B1 (es) | 1995-07-13 | 1998-03-01 | Pharma Mar Sa | Procedimiento de preparacion de didemnina a. |
US6365597B1 (en) * | 1996-02-14 | 2002-04-02 | Aventis Pharmaceuticals Inc. | 4-aza steroids |
US20020077461A1 (en) * | 1996-04-24 | 2002-06-20 | Soren Bjorn | Pharmaceutical formulation |
ES2151277T3 (es) | 1996-05-22 | 2000-12-16 | Protarga Inc | Composiciones que comprenden conjugados de acido cis-docosahexaenoico y taxotere. |
US6156724A (en) | 1996-06-07 | 2000-12-05 | Rinehart; Kenneth L. | Uses of didemnins as immunomodulating agents |
ES2135359T3 (es) | 1996-07-03 | 2002-05-16 | Paxton C G Ltd | Recipientes. |
JP2001503746A (ja) | 1996-10-24 | 2001-03-21 | ザ・ボード・オブ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・イリノイ | ジデムニン類似体の半合成法 |
DE69723728T2 (de) | 1996-10-24 | 2004-06-03 | The Board Of Trustees For The University Of Illinois, Urbana | Totalsynthese des amino hip analogen von didemnin a |
US6034058A (en) | 1997-04-15 | 2000-03-07 | Rinehart; Kenneth L. | Semi-synthetic alanyl dilemnin analogs |
DE69840497D1 (de) | 1997-05-07 | 2009-03-12 | William J Crumb | Verwendung von Aplidine zur Behandlung von kardiovaskulären Erkrankungen |
GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
DE69923322T2 (de) | 1998-07-30 | 2005-12-22 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Verwendung von propionyl-l-carnitin und acetyl-l-carnitin zur herstellung von arzneimittel mit antikrebs wirkung |
US20010021380A1 (en) | 1999-04-19 | 2001-09-13 | Pluenneke John D. | Soluble tumor necrosis factor receptor treatment of medical disorders |
WO2000071135A1 (en) | 1999-05-25 | 2000-11-30 | Point Therapeutics, Inc. | Anti-tumor comprising boroproline compounds |
US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
ATE363910T1 (de) | 1999-11-15 | 2007-06-15 | Pharma Mar Sa | Behandlung von krebserkrankungen durch aplidin |
US6509315B1 (en) | 2000-04-07 | 2003-01-21 | The Trustees Of The University Of Pennsylvania | Didemnin analogs and fragments and methods of making and using them |
WO2001076616A1 (en) | 2000-04-07 | 2001-10-18 | The Trustees Of The University Of Pennsylvania | Tamandarin and didemnin analogs and methods of making and using them |
UA76718C2 (uk) | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
AU2002213053B2 (en) | 2000-10-05 | 2006-12-21 | Immunex Corporation | Nectin polypeptides, polynucleotides, methods of making and use thereof |
AU9402401A (en) | 2000-10-12 | 2002-04-22 | Pharma Mar Sa | Treatment of cancers |
AU2002224417A1 (en) | 2000-10-18 | 2002-04-29 | Immunex Corporation | Methods for treating il-18 mediated disorders |
PT1435991E (pt) | 2001-10-19 | 2009-01-16 | Pharma Mar Sa | Utilização de aplidina para o tratamento de cancro pancreático |
KR20060002778A (ko) | 2003-03-12 | 2006-01-09 | 파르마 마르, 에스.에이. | 개선된 항종양 치료 |
-
1998
- 1998-02-18 GB GBGB9803448.1A patent/GB9803448D0/en not_active Ceased
-
1999
- 1999-02-18 ES ES99905091T patent/ES2175940T3/es not_active Expired - Lifetime
- 1999-02-18 US US09/622,433 patent/US8420130B1/en not_active Expired - Fee Related
- 1999-02-18 EP EP99905091A patent/EP1054686B1/en not_active Expired - Lifetime
- 1999-02-18 CN CNB998050393A patent/CN1170586C/zh not_active Expired - Lifetime
- 1999-02-18 WO PCT/GB1999/000511 patent/WO1999042125A1/en active IP Right Grant
- 1999-02-18 PT PT99905091T patent/PT1054686E/pt unknown
- 1999-02-18 AT AT99905091T patent/ATE217532T1/de active
- 1999-02-18 DK DK99905091T patent/DK1054686T3/da active
- 1999-02-18 JP JP2000532139A patent/JP4536255B2/ja not_active Expired - Lifetime
- 1999-02-18 IL IL137911A patent/IL137911A/en not_active IP Right Cessation
- 1999-02-18 AU AU25389/99A patent/AU754073B2/en not_active Expired
- 1999-02-18 CA CA002321116A patent/CA2321116C/en not_active Expired - Lifetime
- 1999-02-18 KR KR1020007009012A patent/KR100595597B1/ko not_active IP Right Cessation
- 1999-02-18 DE DE69901487T patent/DE69901487T2/de not_active Expired - Lifetime
- 1999-02-18 BR BRPI9908088A patent/BRPI9908088C1/pt not_active IP Right Cessation
-
2001
- 2001-05-07 HK HK01103194A patent/HK1032538A1/xx not_active IP Right Cessation
-
2010
- 2010-03-08 JP JP2010050393A patent/JP2010163443A/ja not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR100595597B1 (ko) | 2006-07-03 |
BR9908088B1 (pt) | 2013-05-21 |
KR20010040993A (ko) | 2001-05-15 |
ES2175940T3 (es) | 2002-11-16 |
BRPI9908088B8 (pt) | 2017-03-07 |
WO1999042125A1 (en) | 1999-08-26 |
JP4536255B2 (ja) | 2010-09-01 |
DK1054686T3 (da) | 2002-06-17 |
EP1054686B1 (en) | 2002-05-15 |
AU754073B2 (en) | 2002-11-07 |
DE69901487T2 (de) | 2002-12-19 |
DE69901487D1 (de) | 2002-06-20 |
CA2321116A1 (en) | 1999-08-26 |
JP2010163443A (ja) | 2010-07-29 |
AU2538999A (en) | 1999-09-06 |
IL137911A (en) | 2006-04-10 |
CN1330551A (zh) | 2002-01-09 |
EP1054686A1 (en) | 2000-11-29 |
PT1054686E (pt) | 2002-09-30 |
IL137911A0 (en) | 2001-10-31 |
US8420130B1 (en) | 2013-04-16 |
CA2321116C (en) | 2009-10-06 |
BR9908088A (pt) | 2000-10-31 |
HK1032538A1 (en) | 2001-07-27 |
JP2002503704A (ja) | 2002-02-05 |
ATE217532T1 (de) | 2002-06-15 |
CN1170586C (zh) | 2004-10-13 |
GB9803448D0 (en) | 1998-04-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
B11N | Dismissal: publication cancelled [chapter 11.14 patent gazette] |
Free format text: ANULADA A PUBLICACAO DE ARQUIVAMENTO DO PEDIDO POR TER SIDO INDEVIDA. |
|
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
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B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 21/05/2013, OBSERVADAS AS CONDICOES LEGAIS. |
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B16C | Correction of notification of the grant [chapter 16.3 patent gazette] | ||
B16C | Correction of notification of the grant [chapter 16.3 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/02/1999 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF |
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B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 18/02/2019 |