DE69434696T2 - Verfahren zur Herstellung von Verbindungen geeignet als Zwischenprodukte - Google Patents

Verfahren zur Herstellung von Verbindungen geeignet als Zwischenprodukte Download PDF

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Publication number
DE69434696T2
DE69434696T2 DE69434696T DE69434696T DE69434696T2 DE 69434696 T2 DE69434696 T2 DE 69434696T2 DE 69434696 T DE69434696 T DE 69434696T DE 69434696 T DE69434696 T DE 69434696T DE 69434696 T2 DE69434696 T2 DE 69434696T2
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DE
Germany
Prior art keywords
palladium
catalyst
triphenylphosphine
formula
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69434696T
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German (de)
English (en)
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DE69434696D1 (de
Inventor
Thomas E. D'ambra
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AMR Technology Inc
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AMR Technology Inc
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Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22176189&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69434696(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AMR Technology Inc filed Critical AMR Technology Inc
Application granted granted Critical
Publication of DE69434696D1 publication Critical patent/DE69434696D1/de
Publication of DE69434696T2 publication Critical patent/DE69434696T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/86—Unsaturated compounds containing keto groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69434696T 1993-06-24 1994-06-21 Verfahren zur Herstellung von Verbindungen geeignet als Zwischenprodukte Expired - Lifetime DE69434696T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8310293A 1993-06-24 1993-06-24
US83102 1993-06-24

Publications (2)

Publication Number Publication Date
DE69434696D1 DE69434696D1 (de) 2006-05-18
DE69434696T2 true DE69434696T2 (de) 2006-11-16

Family

ID=22176189

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69434696T Expired - Lifetime DE69434696T2 (de) 1993-06-24 1994-06-21 Verfahren zur Herstellung von Verbindungen geeignet als Zwischenprodukte
DE69415319T Expired - Lifetime DE69415319T2 (de) 1993-06-24 1994-06-21 Verfahren zur herstellung von piperidinderivaten
DE69433346T Expired - Lifetime DE69433346T2 (de) 1993-06-24 1994-06-21 Herstellung von Verbindungen, die in der Produktion von Piperidin-Derivaten nützlich sind

Family Applications After (2)

Application Number Title Priority Date Filing Date
DE69415319T Expired - Lifetime DE69415319T2 (de) 1993-06-24 1994-06-21 Verfahren zur herstellung von piperidinderivaten
DE69433346T Expired - Lifetime DE69433346T2 (de) 1993-06-24 1994-06-21 Herstellung von Verbindungen, die in der Produktion von Piperidin-Derivaten nützlich sind

Country Status (16)

Country Link
US (9) US5750703A (enExample)
EP (4) EP1026147B1 (enExample)
JP (4) JP3034047B2 (enExample)
KR (2) KR100387347B1 (enExample)
AT (3) ATE254594T1 (enExample)
AU (1) AU670004B2 (enExample)
CA (1) CA2147126C (enExample)
DE (3) DE69434696T2 (enExample)
DK (3) DK0703902T3 (enExample)
ES (3) ES2211444T3 (enExample)
FI (1) FI109691B (enExample)
HU (1) HU226559B1 (enExample)
NO (2) NO308599B1 (enExample)
NZ (1) NZ268513A (enExample)
PT (2) PT1026147E (enExample)
WO (1) WO1995000482A1 (enExample)

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DK0701443T4 (da) * 1992-08-03 2000-12-18 Sepracor Inc Terfenadinmetabolitter og deres optisk rene isomerer til behandling af allergiske lidelser
ATE254594T1 (de) 1993-06-24 2003-12-15 Albany Molecular Res Inc Verbindungen verwendbar als zwischenprodukte zur herstellung von piperidinderivate
US20020007068A1 (en) 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
DK0705245T3 (da) 1993-06-25 2003-04-14 Merrell Pharma Inc Nye mellemprodukter til fremstilling af antihistaminiske 4-diphenylmethyl/diphenylmethoxy-piperidinforbindelser
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US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
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US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
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Also Published As

Publication number Publication date
JP3034047B2 (ja) 2000-04-17
EP1026147A1 (en) 2000-08-09
ATE254594T1 (de) 2003-12-15
DE69415319D1 (de) 1999-01-28
JP2001031650A (ja) 2001-02-06
EP0703902A4 (enExample) 1996-04-10
NO994582L (no) 1995-12-12
ATE322473T1 (de) 2006-04-15
HU9503719D0 (en) 1996-02-28
US5750703A (en) 1998-05-12
AU7174894A (en) 1995-01-17
PT1026147E (pt) 2004-04-30
EP0723958A1 (en) 1996-07-31
ES2261871T3 (es) 2006-11-16
HU226559B1 (en) 2009-03-30
JPH08511806A (ja) 1996-12-10
JP3658291B2 (ja) 2005-06-08
EP0703902A1 (en) 1996-04-03
AU670004B2 (en) 1996-06-27
NZ268513A (en) 1996-09-25
JP3195297B2 (ja) 2001-08-06
US7390906B2 (en) 2008-06-24
ES2211444T3 (es) 2004-07-16
DE69433346D1 (de) 2003-12-24
ATE174589T1 (de) 1999-01-15
JP4124998B2 (ja) 2008-07-23
CA2147126C (en) 1999-08-24
WO1995000482A1 (en) 1995-01-05
DE69434696D1 (de) 2006-05-18
US20080227983A1 (en) 2008-09-18
US5581011A (en) 1996-12-03
EP1369409A1 (en) 2003-12-10
DE69433346T2 (de) 2004-09-09
NO994582D0 (no) 1999-09-21
EP0703902B1 (en) 1998-12-16
DK1026147T3 (da) 2004-03-22
US20060052610A1 (en) 2006-03-09
ES2129130T3 (es) 1999-06-01
FI956270L (fi) 1995-12-27
PT1369409E (pt) 2006-08-31
HUT73235A (en) 1996-07-29
DK1369409T3 (da) 2006-08-14
NO955023L (no) 1995-12-12
EP1026147B1 (en) 2003-11-19
US20060241303A1 (en) 2006-10-26
US7238834B2 (en) 2007-07-03
US5578610A (en) 1996-11-26
DK0703902T3 (da) 1999-08-23
FI956270A0 (fi) 1995-12-27
DE69415319T2 (de) 1999-06-10
JP2002212166A (ja) 2002-07-31
FI109691B (fi) 2002-09-30
KR960703398A (ko) 1996-08-17
KR100387347B1 (ko) 2003-11-28
US5589487A (en) 1996-12-31
EP1369409B1 (en) 2006-04-05
CA2147126A1 (en) 1995-01-05
US5994549A (en) 1999-11-30
US5663412A (en) 1997-09-02
NO308599B1 (no) 2000-10-02
JPH11236373A (ja) 1999-08-31
KR100387348B1 (ko) 2003-06-12
NO955023D0 (no) 1995-12-12

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