AU2001296994A1 - Nmda receptor channel blocker with neuroprotective activity - Google Patents

Nmda receptor channel blocker with neuroprotective activity

Info

Publication number
AU2001296994A1
AU2001296994A1 AU2001296994A AU9699401A AU2001296994A1 AU 2001296994 A1 AU2001296994 A1 AU 2001296994A1 AU 2001296994 A AU2001296994 A AU 2001296994A AU 9699401 A AU9699401 A AU 9699401A AU 2001296994 A1 AU2001296994 A1 AU 2001296994A1
Authority
AU
Australia
Prior art keywords
nmda receptor
channel blocker
neuroprotective activity
receptor channel
neuroprotective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001296994A
Inventor
Sylvie Blondelle
Richard A. Houghten
Mauricio Montal
Kwok-Keung Tai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Publication of AU2001296994A1 publication Critical patent/AU2001296994A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/54—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having at least three carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
AU2001296994A 2000-10-06 2001-10-05 Nmda receptor channel blocker with neuroprotective activity Abandoned AU2001296994A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23873900P 2000-10-06 2000-10-06
US60238739 2000-10-06
PCT/US2001/042521 WO2002028814A2 (en) 2000-10-06 2001-10-05 Nmda receptor channel blocker with neuroprotective activity

Publications (1)

Publication Number Publication Date
AU2001296994A1 true AU2001296994A1 (en) 2002-04-15

Family

ID=22899116

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001296994A Abandoned AU2001296994A1 (en) 2000-10-06 2001-10-05 Nmda receptor channel blocker with neuroprotective activity

Country Status (3)

Country Link
US (1) US7022882B2 (en)
AU (1) AU2001296994A1 (en)
WO (1) WO2002028814A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0703902T3 (en) * 1993-06-24 1999-08-23 Albany Molecular Res Inc Process for the preparation of piperidine derivatives
US7005432B2 (en) 2002-05-16 2006-02-28 Hoffman-La Roche Inc. Substituted imidazol-pyridazine derivatives
US7084180B2 (en) * 2004-01-28 2006-08-01 Velocys, Inc. Fischer-tropsch synthesis using microchannel technology and novel catalyst and microchannel reactor
CN103497114A (en) * 2007-06-29 2014-01-08 埃莫里大学 NMDA receptor antagonists for neuroprotection
RU2499598C2 (en) * 2008-03-27 2013-11-27 Евотек Интернациональ Гмбх Method of treating disorders using selective nr2b subtype nmda receptor antagonist
AU2009244082A1 (en) * 2008-05-09 2009-11-12 Emory University NMDA receptor antagonists for the treatment of neuropsychiatric disorders
WO2023034589A1 (en) * 2021-09-02 2023-03-09 Emory University Glun2b-subunit selective antagonists of the n-methyl-d-aspartate receptors with enhanced potency at acidic ph

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5430044A (en) * 1987-02-06 1995-07-04 Fisons Corporation Arylalkyl-amines and -amides having anticonvulsant and neuroprotective properties
US5242947A (en) * 1988-02-10 1993-09-07 New York University Use of polyamines as ionic-channel regulating agents
US5641861A (en) * 1995-06-07 1997-06-24 Torrey Pines Institute For Molecular Studies μopioid receptor ligands: agonists and antagonists
DK0853484T3 (en) 1995-06-07 2003-01-20 Torrey Pines Inst Newly known MU opioid receptor ligands: agonists and antagonists
US5919897A (en) * 1995-06-07 1999-07-06 Torrey Pines Institute For Molecular Studies MU opioid receptor ligands: agonists and antagonists

Also Published As

Publication number Publication date
US7022882B2 (en) 2006-04-04
US20040054013A1 (en) 2004-03-18
WO2002028814A2 (en) 2002-04-11
WO2002028814A3 (en) 2002-06-27

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