DE69401979T2 - Verfahren zur Herstellung von L-(-)-Carnitin aus Abfallprodukten mit entgegengesetzter Konfiguration - Google Patents

Verfahren zur Herstellung von L-(-)-Carnitin aus Abfallprodukten mit entgegengesetzter Konfiguration

Info

Publication number
DE69401979T2
DE69401979T2 DE69401979T DE69401979T DE69401979T2 DE 69401979 T2 DE69401979 T2 DE 69401979T2 DE 69401979 T DE69401979 T DE 69401979T DE 69401979 T DE69401979 T DE 69401979T DE 69401979 T2 DE69401979 T2 DE 69401979T2
Authority
DE
Germany
Prior art keywords
carnitine
acyl
nitrile
lactone
hours
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69401979T
Other languages
German (de)
English (en)
Other versions
DE69401979D1 (de
Inventor
Roberto Castagnani
Angelis Francesco De
Witt Paolo De
Fabio Giannessi
Domenico Misiti
Maria Ornella Tinti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of DE69401979D1 publication Critical patent/DE69401979D1/de
Application granted granted Critical
Publication of DE69401979T2 publication Critical patent/DE69401979T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Processing Of Solid Wastes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fertilizers (AREA)
  • Switches Operated By Changes In Physical Conditions (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
DE69401979T 1993-04-08 1994-03-31 Verfahren zur Herstellung von L-(-)-Carnitin aus Abfallprodukten mit entgegengesetzter Konfiguration Expired - Lifetime DE69401979T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930226A IT1261230B (it) 1993-04-08 1993-04-08 Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.

Publications (2)

Publication Number Publication Date
DE69401979D1 DE69401979D1 (de) 1997-04-17
DE69401979T2 true DE69401979T2 (de) 1997-06-26

Family

ID=11401703

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69401979T Expired - Lifetime DE69401979T2 (de) 1993-04-08 1994-03-31 Verfahren zur Herstellung von L-(-)-Carnitin aus Abfallprodukten mit entgegengesetzter Konfiguration

Country Status (13)

Country Link
US (1) US5491260A (enExample)
EP (1) EP0623588B1 (enExample)
JP (1) JP3502657B2 (enExample)
KR (1) KR100301951B1 (enExample)
AT (1) ATE150003T1 (enExample)
CA (1) CA2120811C (enExample)
DE (1) DE69401979T2 (enExample)
DK (1) DK0623588T3 (enExample)
ES (1) ES2099563T3 (enExample)
GR (1) GR3023594T3 (enExample)
IT (1) IT1261230B (enExample)
TW (1) TW275613B (enExample)
ZA (1) ZA942428B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10027391A1 (de) * 2000-06-02 2002-02-21 Wella Ag Oligomere und Polymere aus Crotonbetain oder Crotonbetainderivaten

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1261828B (it) 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1276207B1 (it) * 1995-09-29 1997-10-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone
KR100255039B1 (ko) * 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
IT1297120B1 (it) * 1997-12-16 1999-08-03 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina
EP2409965A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine by cycloaddition
EP2409972A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine from B-lactones
EP2468739A1 (en) * 2010-12-22 2012-06-27 Lonza Ltd. A process for the production of carnitine from B-lactones
CN103003257B (zh) * 2010-07-21 2016-03-16 隆萨有限公司 用于由β-内酯生产肉碱的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE664500A (enExample) *
ES332080A1 (es) * 1965-10-15 1967-10-01 Otsuka Pharma Co Ltd Procedimiento para obtencion de complejos de sales opticamente activas de hidroxido de nitrilo,carnitina y acidos glutamicos n-acilos.
IT1156852B (it) * 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
JPS59183694A (ja) * 1983-04-05 1984-10-18 Hamari Yakuhin Kogyo Kk 光学活性なカルニチンの生化学的製造法
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
CH664374A5 (de) * 1985-02-27 1988-02-29 Lonza Ag Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.
US5200526A (en) * 1987-04-27 1993-04-06 The Governors Of The University Of Alberta Syntheses of optically pure α-amino acids from 3-amino-2-oxetanone salts
JPH0291049A (ja) * 1988-09-21 1990-03-30 Lonza Ag ｒ―ブチロベタインの製造方法
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
JPH0751071B2 (ja) * 1989-07-28 1995-06-05 ロンザ リミテッド Ｌ―カルニチンの微生物学的方法による断続的製造方法
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
IT1245699B (it) * 1991-05-29 1994-10-14 Sigma Tau Ind Farmaceuti Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10027391A1 (de) * 2000-06-02 2002-02-21 Wella Ag Oligomere und Polymere aus Crotonbetain oder Crotonbetainderivaten
DE10027391B4 (de) * 2000-06-02 2006-05-04 Wella Ag Oligomere und Polymere aus Crotonbetain oder Crotonbetainderivaten

Also Published As

Publication number Publication date
DE69401979D1 (de) 1997-04-17
EP0623588A1 (en) 1994-11-09
DK0623588T3 (da) 1997-07-21
IT1261230B (it) 1996-05-09
TW275613B (enExample) 1996-05-11
GR3023594T3 (en) 1997-08-29
CA2120811A1 (en) 1994-10-09
ATE150003T1 (de) 1997-03-15
ITRM930226A1 (it) 1994-10-08
JP3502657B2 (ja) 2004-03-02
ZA942428B (en) 1994-11-29
CA2120811C (en) 2004-10-26
JPH06311888A (ja) 1994-11-08
HK1005867A1 (en) 1999-01-29
ES2099563T3 (es) 1997-05-16
ITRM930226A0 (it) 1993-04-08
KR100301951B1 (ko) 2001-10-22
EP0623588B1 (en) 1997-03-12
US5491260A (en) 1996-02-13

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