KR100301951B1 - 반대배치를갖는폐물질로부터l-(-)-카르니틴의제조방법 - Google Patents

반대배치를갖는폐물질로부터l-(-)-카르니틴의제조방법 Download PDF

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Publication number
KR100301951B1
KR100301951B1 KR1019940007343A KR19940007343A KR100301951B1 KR 100301951 B1 KR100301951 B1 KR 100301951B1 KR 1019940007343 A KR1019940007343 A KR 1019940007343A KR 19940007343 A KR19940007343 A KR 19940007343A KR 100301951 B1 KR100301951 B1 KR 100301951B1
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KR
South Korea
Prior art keywords
carnitine
represented
structural formula
formula
acyl
Prior art date
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Expired - Fee Related
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KR1019940007343A
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English (en)
Korean (ko)
Inventor
기아네시파비오
카스타그나니로베르토
틴티마리아오넬라
데안젤리스프란세스코
데위트파올로
미시티도메니코
Original Assignee
알도 파시
시그마타우 인두스트리에 파르마슈티케 리우니테 에스.피.에이.
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Application granted granted Critical
Publication of KR100301951B1 publication Critical patent/KR100301951B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Processing Of Solid Wastes (AREA)
  • Fertilizers (AREA)
  • Switches Operated By Changes In Physical Conditions (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
KR1019940007343A 1993-04-08 1994-04-08 반대배치를갖는폐물질로부터l-(-)-카르니틴의제조방법 Expired - Fee Related KR100301951B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM930226A IT1261230B (it) 1993-04-08 1993-04-08 Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.
ITRM93A000226 1993-04-08

Publications (1)

Publication Number Publication Date
KR100301951B1 true KR100301951B1 (ko) 2001-10-22

Family

ID=11401703

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940007343A Expired - Fee Related KR100301951B1 (ko) 1993-04-08 1994-04-08 반대배치를갖는폐물질로부터l-(-)-카르니틴의제조방법

Country Status (13)

Country Link
US (1) US5491260A (enExample)
EP (1) EP0623588B1 (enExample)
JP (1) JP3502657B2 (enExample)
KR (1) KR100301951B1 (enExample)
AT (1) ATE150003T1 (enExample)
CA (1) CA2120811C (enExample)
DE (1) DE69401979T2 (enExample)
DK (1) DK0623588T3 (enExample)
ES (1) ES2099563T3 (enExample)
GR (1) GR3023594T3 (enExample)
IT (1) IT1261230B (enExample)
TW (1) TW275613B (enExample)
ZA (1) ZA942428B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1261828B (it) 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1276207B1 (it) * 1995-09-29 1997-10-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone
KR100255039B1 (ko) * 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
IT1297120B1 (it) * 1997-12-16 1999-08-03 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina
DE10027391B4 (de) * 2000-06-02 2006-05-04 Wella Ag Oligomere und Polymere aus Crotonbetain oder Crotonbetainderivaten
KR20130093078A (ko) * 2010-07-21 2013-08-21 론차리미티드 베타-락톤으로부터 카르니틴의 제조방법
EP2468739A1 (en) * 2010-12-22 2012-06-27 Lonza Ltd. A process for the production of carnitine from B-lactones
EP2409965A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine by cycloaddition
EP2409972A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine from B-lactones

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE664500A (enExample) *
ES332080A1 (es) * 1965-10-15 1967-10-01 Otsuka Pharma Co Ltd Procedimiento para obtencion de complejos de sales opticamente activas de hidroxido de nitrilo,carnitina y acidos glutamicos n-acilos.
IT1156852B (it) * 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
JPS59183694A (ja) * 1983-04-05 1984-10-18 Hamari Yakuhin Kogyo Kk 光学活性なカルニチンの生化学的製造法
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
CH664374A5 (de) * 1985-02-27 1988-02-29 Lonza Ag Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.
US5200526A (en) * 1987-04-27 1993-04-06 The Governors Of The University Of Alberta Syntheses of optically pure α-amino acids from 3-amino-2-oxetanone salts
JPH0291049A (ja) * 1988-09-21 1990-03-30 Lonza Ag ｒ―ブチロベタインの製造方法
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
CA2021869C (en) * 1989-07-28 2000-09-05 Frans Hoeks Process for microbiological batch production of l-carnitine
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
IT1245699B (it) * 1991-05-29 1994-10-14 Sigma Tau Ind Farmaceuti Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

Also Published As

Publication number Publication date
DE69401979T2 (de) 1997-06-26
CA2120811C (en) 2004-10-26
ES2099563T3 (es) 1997-05-16
EP0623588A1 (en) 1994-11-09
IT1261230B (it) 1996-05-09
DE69401979D1 (de) 1997-04-17
JPH06311888A (ja) 1994-11-08
US5491260A (en) 1996-02-13
GR3023594T3 (en) 1997-08-29
HK1005867A1 (en) 1999-01-29
ZA942428B (en) 1994-11-29
JP3502657B2 (ja) 2004-03-02
TW275613B (enExample) 1996-05-11
ATE150003T1 (de) 1997-03-15
EP0623588B1 (en) 1997-03-12
CA2120811A1 (en) 1994-10-09
DK0623588T3 (da) 1997-07-21
ITRM930226A0 (it) 1993-04-08
ITRM930226A1 (it) 1994-10-08

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