JP3502657B2 - 反対立体配置の廃棄物からのｌ−（−）−カルニチンの改良製造法 - Google Patents

反対立体配置の廃棄物からのｌ−（−）−カルニチンの改良製造法

Info

Publication number
JP3502657B2
JP3502657B2 JP06928994A JP6928994A JP3502657B2 JP 3502657 B2 JP3502657 B2 JP 3502657B2 JP 06928994 A JP06928994 A JP 06928994A JP 6928994 A JP6928994 A JP 6928994A JP 3502657 B2 JP3502657 B2 JP 3502657B2
Authority
JP
Japan
Prior art keywords
carnitine
acyl
formula
acylating agent
precursor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP06928994A
Other languages
English (en)
Japanese (ja)
Other versions
JPH06311888A (ja
Inventor
ファビオ・ジャネッシ
ロベルト・カスタニャーニ
マリア・オルネーラ・チンチ
フランチェスコ・デ・アンジェリス
パオロ・デ・ウィット
ドメニコ・ミシチ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of JPH06311888A publication Critical patent/JPH06311888A/ja
Application granted granted Critical
Publication of JP3502657B2 publication Critical patent/JP3502657B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/10—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having one or more double bonds between ring members or between ring members and non-ring members
    • C07D305/12—Beta-lactones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Processing Of Solid Wastes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fertilizers (AREA)
  • Switches Operated By Changes In Physical Conditions (AREA)
  • Lighting Device Outwards From Vehicle And Optical Signal (AREA)
JP06928994A 1993-04-08 1994-04-07 反対立体配置の廃棄物からのｌ−（−）−カルニチンの改良製造法 Expired - Fee Related JP3502657B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT93A000226 1993-04-08
ITRM930226A IT1261230B (it) 1993-04-08 1993-04-08 Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da suoi precursori aventi opposta configurazione.

Publications (2)

Publication Number Publication Date
JPH06311888A JPH06311888A (ja) 1994-11-08
JP3502657B2 true JP3502657B2 (ja) 2004-03-02

Family

ID=11401703

Family Applications (1)

Application Number Title Priority Date Filing Date
JP06928994A Expired - Fee Related JP3502657B2 (ja) 1993-04-08 1994-04-07 反対立体配置の廃棄物からのｌ−（−）−カルニチンの改良製造法

Country Status (13)

Country Link
US (1) US5491260A (enExample)
EP (1) EP0623588B1 (enExample)
JP (1) JP3502657B2 (enExample)
KR (1) KR100301951B1 (enExample)
AT (1) ATE150003T1 (enExample)
CA (1) CA2120811C (enExample)
DE (1) DE69401979T2 (enExample)
DK (1) DK0623588T3 (enExample)
ES (1) ES2099563T3 (enExample)
GR (1) GR3023594T3 (enExample)
IT (1) IT1261230B (enExample)
TW (1) TW275613B (enExample)
ZA (1) ZA942428B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1261828B (it) 1993-07-14 1996-06-03 Sigma Tau Ind Farmaceuti Esteri di acil l-carnitine e composizioni farmaceutiche che li contengono per il trattamento dello shock endotossico.
IT1276207B1 (it) * 1995-09-29 1997-10-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione del (s)-b-idrossi-gamma- butirrolattone
KR100255039B1 (ko) * 1997-07-28 2000-05-01 박영구 L-카르니틴의제조방법
IT1297120B1 (it) * 1997-12-16 1999-08-03 Sigma Tau Ind Farmaceuti Procedimento per la produzione di (r)-3-idrossi-4-butirrolattone utile nella preparazione della (r)-carnitina
DE10027391B4 (de) * 2000-06-02 2006-05-04 Wella Ag Oligomere und Polymere aus Crotonbetain oder Crotonbetainderivaten
EP2409965A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine by cycloaddition
EP2409972A1 (en) * 2010-07-21 2012-01-25 Lonza Ltd. A process for the production of carnitine from B-lactones
EP2468739A1 (en) * 2010-12-22 2012-06-27 Lonza Ltd. A process for the production of carnitine from B-lactones
CN103003257B (zh) * 2010-07-21 2016-03-16 隆萨有限公司 用于由β-内酯生产肉碱的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE664500A (enExample) *
ES332080A1 (es) * 1965-10-15 1967-10-01 Otsuka Pharma Co Ltd Procedimiento para obtencion de complejos de sales opticamente activas de hidroxido de nitrilo,carnitina y acidos glutamicos n-acilos.
IT1156852B (it) * 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni
IT1136945B (it) * 1981-03-18 1986-09-03 Anic Spa Processo per la preparazione di l-carnitina
JPS59183694A (ja) * 1983-04-05 1984-10-18 Hamari Yakuhin Kogyo Kk 光学活性なカルニチンの生化学的製造法
JPS59192095A (ja) * 1983-04-13 1984-10-31 Ajinomoto Co Inc Ｌ−カルニチンの製造法
DD221905B1 (de) * 1983-11-03 1987-03-18 Univ Leipzig Verfahren zur herstellung von l(-)-carnitin und seinen derivaten
CH664374A5 (de) * 1985-02-27 1988-02-29 Lonza Ag Verfahren zur herstellung von l-carnitin auf mikrobiologischem weg.
US5200526A (en) * 1987-04-27 1993-04-06 The Governors Of The University Of Alberta Syntheses of optically pure α-amino acids from 3-amino-2-oxetanone salts
JPH0291049A (ja) * 1988-09-21 1990-03-30 Lonza Ag ｒ―ブチロベタインの製造方法
IT1231751B (it) * 1989-04-12 1991-12-21 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r(+) amminocarnitina e s(-) amminocarnitina
JPH0751071B2 (ja) * 1989-07-28 1995-06-05 ロンザ リミテッド Ｌ―カルニチンの微生物学的方法による断続的製造方法
IT1240833B (it) * 1990-05-14 1993-12-17 Sigma Tau Ind Farmaceuti Procedimento biocatalitico per la produzione di l-(-)- carnitina da crotonilbetaina e ceppi di proteeae per l'uso in tale procedimento
IT1245699B (it) * 1991-05-29 1994-10-14 Sigma Tau Ind Farmaceuti Derivati della l-carnitina quali agenti terapeutici per il trattamento delle miopatie, della degenarazione neuronale e per inibire la proteolisi
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.

Also Published As

Publication number Publication date
DE69401979D1 (de) 1997-04-17
EP0623588A1 (en) 1994-11-09
DK0623588T3 (da) 1997-07-21
IT1261230B (it) 1996-05-09
TW275613B (enExample) 1996-05-11
GR3023594T3 (en) 1997-08-29
CA2120811A1 (en) 1994-10-09
ATE150003T1 (de) 1997-03-15
ITRM930226A1 (it) 1994-10-08
ZA942428B (en) 1994-11-29
CA2120811C (en) 2004-10-26
JPH06311888A (ja) 1994-11-08
HK1005867A1 (en) 1999-01-29
ES2099563T3 (es) 1997-05-16
ITRM930226A0 (it) 1993-04-08
KR100301951B1 (ko) 2001-10-22
EP0623588B1 (en) 1997-03-12
US5491260A (en) 1996-02-13
DE69401979T2 (de) 1997-06-26

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