DE69903320T2 - Verfahren zur herstellung von r-(-)-carnitin - Google Patents

Verfahren zur herstellung von r-(-)-carnitin

Info

Publication number
DE69903320T2
DE69903320T2 DE69903320T DE69903320T DE69903320T2 DE 69903320 T2 DE69903320 T2 DE 69903320T2 DE 69903320 T DE69903320 T DE 69903320T DE 69903320 T DE69903320 T DE 69903320T DE 69903320 T2 DE69903320 T2 DE 69903320T2
Authority
DE
Germany
Prior art keywords
yield
compound
conversion
carnitine
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69903320T
Other languages
English (en)
Other versions
DE69903320D1 (de
Inventor
Fabio Giannessi
Ornella Tinti
Angelis Francesco De
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Application granted granted Critical
Publication of DE69903320D1 publication Critical patent/DE69903320D1/de
Publication of DE69903320T2 publication Critical patent/DE69903320T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
DE69903320T 1998-07-31 1999-07-27 Verfahren zur herstellung von r-(-)-carnitin Expired - Fee Related DE69903320T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI001796A IT1301977B1 (it) 1998-07-31 1998-07-31 Procedimento per la preparazione di r-(-)-carnitina
PCT/IT1999/000241 WO2000006532A2 (en) 1998-07-31 1999-07-27 Process for the preparation of r-(-)-carnitine

Publications (2)

Publication Number Publication Date
DE69903320D1 DE69903320D1 (de) 2002-11-07
DE69903320T2 true DE69903320T2 (de) 2003-06-18

Family

ID=11380580

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69903320T Expired - Fee Related DE69903320T2 (de) 1998-07-31 1999-07-27 Verfahren zur herstellung von r-(-)-carnitin

Country Status (12)

Country Link
US (1) US6316667B2 (de)
EP (1) EP1100768B1 (de)
JP (1) JP2002521469A (de)
KR (1) KR100614545B1 (de)
AT (1) ATE225329T1 (de)
AU (1) AU5193499A (de)
DE (1) DE69903320T2 (de)
DK (1) DK1100768T3 (de)
ES (1) ES2184488T3 (de)
IT (1) IT1301977B1 (de)
PT (1) PT1100768E (de)
WO (1) WO2000006532A2 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288239B1 (en) * 2000-09-19 2001-09-11 Board Of Trustees Operating Michigan State University 5-trityloxymethyl-oxazolidinones and process for the preparation thereof
AU2003294212B2 (en) * 2002-08-06 2010-01-07 Pharmasset Inc. Processes for preparing 1,3-dioxolane nucleosides
CN100335457C (zh) * 2005-09-08 2007-09-05 上海交通大学 3－位手性羟基被保护的3，4－二羟基丁酸酯及其制备方法
KR100846673B1 (ko) 2006-03-22 2008-07-16 엔자이텍 주식회사 엘-카르니틴의 제조방법
CN105801572B (zh) * 2016-05-12 2018-11-06 山东罗欣药业集团恒欣药业有限公司 一种利伐沙班的制备方法
CN106749073B (zh) * 2016-11-08 2019-06-18 山东裕欣药业有限公司 一种利奈唑胺的制备方法
CN116655481B (zh) * 2023-06-14 2023-11-28 海南卓科制药有限公司 一种工业化合成左卡尼汀的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2710688B2 (ja) * 1990-10-09 1998-02-10 鐘淵化学工業株式会社 ４―ブロモ―３―ヒドロキシ酪酸エステル誘導体の製造法
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
US5473104A (en) * 1994-09-13 1995-12-05 Neurocrine Biosciences, Inc. Process for the preparation of L-carnitine

Also Published As

Publication number Publication date
EP1100768A2 (de) 2001-05-23
ITMI981796A1 (it) 2000-01-31
KR100614545B1 (ko) 2006-08-25
IT1301977B1 (it) 2000-07-20
WO2000006532A3 (en) 2000-05-11
ATE225329T1 (de) 2002-10-15
AU5193499A (en) 2000-02-21
EP1100768B1 (de) 2002-10-02
PT1100768E (pt) 2003-02-28
US6316667B2 (en) 2001-11-13
DE69903320D1 (de) 2002-11-07
KR20010071884A (ko) 2001-07-31
DK1100768T3 (da) 2003-02-03
US20010031892A1 (en) 2001-10-18
ES2184488T3 (es) 2003-04-01
ITMI981796A0 (it) 1998-07-31
WO2000006532A2 (en) 2000-02-10
JP2002521469A (ja) 2002-07-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee