DE69315026D1 - Verfahren zur Herstellung einer Zubereitung von Mikrosphären mit verzögerter Freigabe - Google Patents

Verfahren zur Herstellung einer Zubereitung von Mikrosphären mit verzögerter Freigabe

Info

Publication number
DE69315026D1
DE69315026D1 DE69315026T DE69315026T DE69315026D1 DE 69315026 D1 DE69315026 D1 DE 69315026D1 DE 69315026 T DE69315026 T DE 69315026T DE 69315026 T DE69315026 T DE 69315026T DE 69315026 D1 DE69315026 D1 DE 69315026D1
Authority
DE
Germany
Prior art keywords
water
give
active ingredient
medicament
organic solvent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69315026T
Other languages
English (en)
Other versions
DE69315026T2 (de
Inventor
Masao Kobayashi
Yukiko Nishioka
Takehiko Suzuki
Yasuhisa Matsukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of DE69315026D1 publication Critical patent/DE69315026D1/de
Publication of DE69315026T2 publication Critical patent/DE69315026T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69315026T 1992-07-16 1993-07-16 Verfahren zur Herstellung einer Zubereitung von Mikrosphären mit verzögerter Freigabe Expired - Lifetime DE69315026T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4189181A JP2651320B2 (ja) 1992-07-16 1992-07-16 徐放性マイクロスフェア製剤の製造方法

Publications (2)

Publication Number Publication Date
DE69315026D1 true DE69315026D1 (de) 1997-12-11
DE69315026T2 DE69315026T2 (de) 1998-03-26

Family

ID=16236857

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69315026T Expired - Lifetime DE69315026T2 (de) 1992-07-16 1993-07-16 Verfahren zur Herstellung einer Zubereitung von Mikrosphären mit verzögerter Freigabe

Country Status (11)

Country Link
US (1) US5556642A (de)
EP (1) EP0586838B1 (de)
JP (1) JP2651320B2 (de)
KR (1) KR100211435B1 (de)
AT (1) ATE159854T1 (de)
CA (1) CA2099941C (de)
DE (1) DE69315026T2 (de)
DK (1) DK0586838T3 (de)
ES (1) ES2110544T3 (de)
GR (1) GR3025297T3 (de)
TW (1) TW227988B (de)

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Also Published As

Publication number Publication date
ATE159854T1 (de) 1997-11-15
TW227988B (de) 1994-08-11
ES2110544T3 (es) 1998-02-16
JP2651320B2 (ja) 1997-09-10
DE69315026T2 (de) 1998-03-26
DK0586838T3 (da) 1998-07-27
CA2099941A1 (en) 1994-01-17
KR940001882A (ko) 1994-02-16
GR3025297T3 (en) 1998-02-27
EP0586838A1 (de) 1994-03-16
EP0586838B1 (de) 1997-11-05
JPH0632732A (ja) 1994-02-08
CA2099941C (en) 1999-12-28
US5556642A (en) 1996-09-17
KR100211435B1 (ko) 1999-08-02

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