ES2110544T3 - Procedimiento para la fabricacion de una preparacion a base de microesferas de liberacion sostenida. - Google Patents

Procedimiento para la fabricacion de una preparacion a base de microesferas de liberacion sostenida.

Info

Publication number
ES2110544T3
ES2110544T3 ES93111455T ES93111455T ES2110544T3 ES 2110544 T3 ES2110544 T3 ES 2110544T3 ES 93111455 T ES93111455 T ES 93111455T ES 93111455 T ES93111455 T ES 93111455T ES 2110544 T3 ES2110544 T3 ES 2110544T3
Authority
ES
Spain
Prior art keywords
water
sustained release
give
active ingredient
microspheres
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93111455T
Other languages
English (en)
Inventor
Masao Kobayashi
Yukiko Nishioka
Takehiko Suzuki
Yasuhisa Matsukawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Seiyaku Co Ltd
Original Assignee
Tanabe Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tanabe Seiyaku Co Ltd filed Critical Tanabe Seiyaku Co Ltd
Application granted granted Critical
Publication of ES2110544T3 publication Critical patent/ES2110544T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2984—Microcapsule with fluid core [includes liposome]
    • Y10T428/2985—Solid-walled microcapsule from synthetic polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN METODO PARA PRODUCIR PREPARACION DE MICROESFERA MANTENIDA LIBRE PARA MEDICAMENTO SOLUBLE EN AGUA, EL CUAL TIENE ALTA EFICIENCIA DE INCORPORACION DEL MEDICAMENTO Y REDUCIDA EMISION INICIAL, EL CUAL COMPRENDE DISOLVER INGREDIENTE ACTIVO FARMACEUTICO SOLUBLE EN AGUA Y POLIMERO BIODEGRABLE INSOLUBLE EN AGUA EN UNO O DOS DISOLVENTES EN LOS CUALES AMBOS PUEDEN DISOLVERSE, ELIMINAR EL DISOLVENTE PARA DAR UNA DISPERSION SOLIDA QUE TIENE EL INGREDIENTE ACTIVO FARMACEUTICO SOLUBLE EN AGUA DISPERSADO EN DICHO POLIMERO BIODEGRADABLE A NIVEL MOLECULAR, Y ADICIONALMENTE, DISOLVER DICHA DISPERSION SOLIDA EN UN DISOLVENTE ORGANICO QUE SEA INMISCIBLE EN AGUA Y QUE TIENE UN PUNTO DE EBULLICION POR DEBAJO DE 100 ANTE EN UNA FASE ACUOSA QUE CONTIENE AGENTE EMULGENTE PARA DAR EMULSION O/W, Y SEGUIDO POR LA ELIMINACION DEL DISOLVENTE ORGANICO DESDE LA FASE DE ACEITE DE LA EMULSION RESULTANTE.
ES93111455T 1992-07-16 1993-07-16 Procedimiento para la fabricacion de una preparacion a base de microesferas de liberacion sostenida. Expired - Lifetime ES2110544T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4189181A JP2651320B2 (ja) 1992-07-16 1992-07-16 徐放性マイクロスフェア製剤の製造方法

Publications (1)

Publication Number Publication Date
ES2110544T3 true ES2110544T3 (es) 1998-02-16

Family

ID=16236857

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93111455T Expired - Lifetime ES2110544T3 (es) 1992-07-16 1993-07-16 Procedimiento para la fabricacion de una preparacion a base de microesferas de liberacion sostenida.

Country Status (11)

Country Link
US (1) US5556642A (es)
EP (1) EP0586838B1 (es)
JP (1) JP2651320B2 (es)
KR (1) KR100211435B1 (es)
AT (1) ATE159854T1 (es)
CA (1) CA2099941C (es)
DE (1) DE69315026T2 (es)
DK (1) DK0586838T3 (es)
ES (1) ES2110544T3 (es)
GR (1) GR3025297T3 (es)
TW (1) TW227988B (es)

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Also Published As

Publication number Publication date
US5556642A (en) 1996-09-17
DE69315026T2 (de) 1998-03-26
EP0586838A1 (en) 1994-03-16
TW227988B (es) 1994-08-11
ATE159854T1 (de) 1997-11-15
DK0586838T3 (da) 1998-07-27
KR100211435B1 (ko) 1999-08-02
KR940001882A (ko) 1994-02-16
CA2099941A1 (en) 1994-01-17
JPH0632732A (ja) 1994-02-08
CA2099941C (en) 1999-12-28
JP2651320B2 (ja) 1997-09-10
EP0586838B1 (en) 1997-11-05
GR3025297T3 (en) 1998-02-27
DE69315026D1 (de) 1997-12-11

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