DE69221831T2 - Arzneimittel mit Angiotensin-II-antagonistische Wirkung - Google Patents

Arzneimittel mit Angiotensin-II-antagonistische Wirkung

Info

Publication number
DE69221831T2
DE69221831T2 DE69221831T DE69221831T DE69221831T2 DE 69221831 T2 DE69221831 T2 DE 69221831T2 DE 69221831 T DE69221831 T DE 69221831T DE 69221831 T DE69221831 T DE 69221831T DE 69221831 T2 DE69221831 T2 DE 69221831T2
Authority
DE
Germany
Prior art keywords
compound
formula
melting point
lower melting
angiotensin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69221831T
Other languages
English (en)
Other versions
DE69221831D1 (de
Inventor
Tadashi Makino
Yoshio Mizukami
Jun-Ichi Kikuta
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Takeda Pharmaceutical Co Ltd
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=17938952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69221831(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of DE69221831D1 publication Critical patent/DE69221831D1/de
Publication of DE69221831T2 publication Critical patent/DE69221831T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
DE69221831T 1991-11-20 1992-11-19 Arzneimittel mit Angiotensin-II-antagonistische Wirkung Expired - Lifetime DE69221831T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30492491 1991-11-20

Publications (2)

Publication Number Publication Date
DE69221831D1 DE69221831D1 (de) 1997-10-02
DE69221831T2 true DE69221831T2 (de) 1998-01-02

Family

ID=17938952

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69221831T Expired - Lifetime DE69221831T2 (de) 1991-11-20 1992-11-19 Arzneimittel mit Angiotensin-II-antagonistische Wirkung
DE69233424T Expired - Lifetime DE69233424T2 (de) 1991-11-20 1992-11-19 Pharmazeutische Zusammensetzungen aus heterozyklischen Angiotensin-II antagonisten und öligen Substanzen zur oralen Verabreichung und deren Herstellungsverfahren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69233424T Expired - Lifetime DE69233424T2 (de) 1991-11-20 1992-11-19 Pharmazeutische Zusammensetzungen aus heterozyklischen Angiotensin-II antagonisten und öligen Substanzen zur oralen Verabreichung und deren Herstellungsverfahren

Country Status (18)

Country Link
US (1) US5534534A (de)
EP (3) EP0782852B1 (de)
KR (1) KR100256633B1 (de)
CN (1) CN1047518C (de)
AT (2) ATE157248T1 (de)
AU (1) AU659691B2 (de)
BR (1) BR1100336A (de)
CA (1) CA2083305C (de)
DE (2) DE69221831T2 (de)
DK (1) DK0546358T3 (de)
ES (1) ES2104797T3 (de)
FI (2) FI111604B (de)
GR (1) GR3025338T3 (de)
HU (1) HU211608A9 (de)
MX (1) MX9206634A (de)
NO (1) NO304408B1 (de)
NZ (1) NZ245175A (de)
TW (1) TW284688B (de)

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US6297239B1 (en) 1997-10-08 2001-10-02 Merck & Co., Inc. Inhibitors of prenyl-protein transferase
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CL2007001195A1 (es) * 2006-04-27 2008-01-04 Takeda Pharmaceutical Composicion farmaceutica solida que comprende un nucleo con un compuesto derivado de bencimidazol y una grasa o aceite, una primera capa que comprende un polimero de alto peso molecular que recubre el nucleo y una segunda capa que comprende pioglitazona, util para tratar enfermedades circulatorias.
AU2007282400B2 (en) * 2006-08-10 2012-08-30 Takeda Pharmaceutical Company Limited Pharmaceutical composition
WO2008045006A1 (en) * 2006-10-11 2008-04-17 Fako Ilaclari A. S. Formulations of candesartan
ES2301401B1 (es) * 2006-11-28 2009-06-08 Laboratorios Liconsa S.A. Composicion farmaceutica solida estabilizada de candesartan cilexetilo.
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JP5283632B2 (ja) * 2007-03-28 2013-09-04 武田薬品工業株式会社 ベンズイミダゾール−７−カルボキシレート誘導体およびｐＨ調整剤を含有する固形医薬組成物
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SI2165702T1 (sl) 2008-09-17 2012-05-31 Helm Ag Stabilni in z lahkoto raztopljeni sestavki kandesartan cileksetila pripravljeni z vlažno granulacijo
US9387249B2 (en) 2008-12-23 2016-07-12 Takeda Pharmaceutical Company Limited Methods of treating hypertension with at least one angiotensin II receptor blocker and chlorthalidone
ES2364011B1 (es) 2009-11-20 2013-01-24 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares.
PL2624696T3 (pl) 2010-10-06 2017-07-31 Glaxosmithkline Llc Pochodne benzimidazolu jako inhibitory kinazy PI3
CN102138920A (zh) * 2011-02-24 2011-08-03 海南中济医药科技有限公司 一种含有坎地沙坦酯和氢氯噻嗪的药物组合物及其制备方法
CN102357095A (zh) * 2011-07-12 2012-02-22 迪沙药业集团有限公司 稳定的药物组合物
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Also Published As

Publication number Publication date
CN1072338A (zh) 1993-05-26
FI925270A0 (fi) 1992-11-19
DK0546358T3 (da) 1998-03-09
KR930009606A (ko) 1993-06-21
NO924417L (no) 1993-05-21
EP0546358B1 (de) 1997-08-27
NZ245175A (en) 1994-07-26
EP1468683A2 (de) 2004-10-20
CN1047518C (zh) 1999-12-22
FI20030210A (fi) 2003-02-12
KR100256633B1 (ko) 2000-05-15
AU2839192A (en) 1993-05-27
AU659691B2 (en) 1995-05-25
NO924417D0 (no) 1992-11-16
FI925270A (fi) 1993-05-21
HU211608A9 (en) 1995-12-28
TW284688B (de) 1996-09-01
NO304408B1 (no) 1998-12-14
GR3025338T3 (en) 1998-02-27
EP0546358A2 (de) 1993-06-16
DE69233424D1 (de) 2004-11-04
EP0546358A3 (de) 1994-03-30
EP0782852B1 (de) 2004-09-29
CA2083305A1 (en) 1993-05-21
BR1100336A (pt) 2000-04-18
ATE277602T1 (de) 2004-10-15
EP1468683A3 (de) 2012-06-06
DE69233424T2 (de) 2005-02-17
ATE157248T1 (de) 1997-09-15
FI111604B (fi) 2003-08-29
DE69221831D1 (de) 1997-10-02
CA2083305C (en) 2003-12-09
EP0782852A1 (de) 1997-07-09
MX9206634A (es) 1993-05-31
US5534534A (en) 1996-07-09
ES2104797T3 (es) 1997-10-16

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