GR3025338T3 - Pharmaceutical compositions with angiotensin-II-antagonistic activity - Google Patents

Pharmaceutical compositions with angiotensin-II-antagonistic activity

Info

Publication number
GR3025338T3
GR3025338T3 GR970402980T GR970402980T GR3025338T3 GR 3025338 T3 GR3025338 T3 GR 3025338T3 GR 970402980 T GR970402980 T GR 970402980T GR 970402980 T GR970402980 T GR 970402980T GR 3025338 T3 GR3025338 T3 GR 3025338T3
Authority
GR
Greece
Prior art keywords
compound
formula
melting point
angiotensin
lower melting
Prior art date
Application number
GR970402980T
Other languages
English (en)
Inventor
Tadashi Makino
Yoshio Mizukami
Jun-Ichi Kikuta
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=17938952&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3025338(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of GR3025338T3 publication Critical patent/GR3025338T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
GR970402980T 1991-11-20 1997-11-11 Pharmaceutical compositions with angiotensin-II-antagonistic activity GR3025338T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP30492491 1991-11-20

Publications (1)

Publication Number Publication Date
GR3025338T3 true GR3025338T3 (en) 1998-02-27

Family

ID=17938952

Family Applications (1)

Application Number Title Priority Date Filing Date
GR970402980T GR3025338T3 (en) 1991-11-20 1997-11-11 Pharmaceutical compositions with angiotensin-II-antagonistic activity

Country Status (18)

Country Link
US (1) US5534534A (el)
EP (3) EP0546358B1 (el)
KR (1) KR100256633B1 (el)
CN (1) CN1047518C (el)
AT (2) ATE157248T1 (el)
AU (1) AU659691B2 (el)
BR (1) BR1100336A (el)
CA (1) CA2083305C (el)
DE (2) DE69233424T2 (el)
DK (1) DK0546358T3 (el)
ES (1) ES2104797T3 (el)
FI (2) FI111604B (el)
GR (1) GR3025338T3 (el)
HU (1) HU211608A9 (el)
MX (1) MX9206634A (el)
NO (1) NO304408B1 (el)
NZ (1) NZ245175A (el)
TW (1) TW284688B (el)

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AU679616B2 (en) * 1994-04-19 1997-07-03 Tanabe Seiyaku Co., Ltd. Imidazopyridine derivatives and process for preparing the same
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WO2005037821A2 (en) * 2003-10-16 2005-04-28 Teva Pharmaceutical Industries Ltd. Preparation of candesartan cilexetil
US20050175689A1 (en) * 2003-10-27 2005-08-11 Yamanouchi Pharmaceutical Co., Ltd. Coated fine particles containing drug for intrabuccally fast disintegrating tablet
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WO2005117591A2 (en) * 2004-05-28 2005-12-15 Andrx Labs Llc Novel pharmaceutical formulation containing a biguanide and an angiotensin antagonist
EP1832288B1 (en) * 2004-12-27 2012-06-20 Astellas Pharma Inc. Stable granular pharmaceutical composition of solifenacin or its salt
CA2594332A1 (en) * 2005-01-06 2006-07-13 Elan Pharma International Ltd. Nanoparticulate candesartan formulations
US20060194858A1 (en) * 2005-01-14 2006-08-31 Omer Malachi Preparation of crude candesartan cilexetil
EP1843754B1 (en) * 2005-01-26 2011-08-03 LEK Pharmaceuticals d.d. New pharmaceutical composition containing candesartan cilexetil as lipophilic crystalline substance
KR100978592B1 (ko) * 2005-05-10 2010-08-27 테바 파마슈티컬 인더스트리즈 리미티드 안정한 미세 분말 칸데사탄 실렉세틸 및 이것의 제조 방법
US7815939B2 (en) * 2005-07-20 2010-10-19 Astellas Pharma Inc. Coated fine particles containing drug for intrabuccally fast disintegrating dosage forms
AR060663A1 (es) * 2006-04-27 2008-07-02 Takeda Pharmaceutical Composicion farmaceutica solida
JP5361188B2 (ja) * 2006-08-10 2013-12-04 武田薬品工業株式会社 医薬組成物
WO2008045006A1 (en) * 2006-10-11 2008-04-17 Fako Ilaclari A. S. Formulations of candesartan
ES2301401B1 (es) * 2006-11-28 2009-06-08 Laboratorios Liconsa S.A. Composicion farmaceutica solida estabilizada de candesartan cilexetilo.
EP1952806A1 (en) 2007-02-01 2008-08-06 Helm AG Process for the preparation of adsorbates of candesartan
DE602008002371D1 (de) * 2007-03-08 2010-10-14 Teva Pharma Pharmazeutische zusammensetzung mit candesartan-cilexetil
PT2124903T (pt) * 2007-03-28 2019-09-26 Takeda Pharmaceuticals Co Composição farmacêutica sólida compreendendo um derivado de benzimidazole-7-carboxilato e um agente de controlo de ph
WO2008134013A2 (en) 2007-04-25 2008-11-06 Teva Pharmaceutical Industries Ltd. Pharmaceutical excipient complex
US20100278909A1 (en) * 2007-06-06 2010-11-04 Dexcel Ltd. Process for forming solid oral dosage forms of angiotensin ii receptor antagonists
DE102007052070A1 (de) 2007-10-30 2009-05-07 Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg Candesartancilexetil
SI2165702T1 (sl) 2008-09-17 2012-05-31 Helm Ag Stabilni in z lahkoto raztopljeni sestavki kandesartan cileksetila pripravljeni z vlažno granulacijo
WO2010075347A2 (en) 2008-12-23 2010-07-01 Takeda Pharmaceutical Company Limited Methods of treating hypertension with at least one angiotensin ii receptor blocker and chlorthalidone
ES2364011B1 (es) 2009-11-20 2013-01-24 Gp Pharm, S.A. Cápsulas de principios activos farmacéuticos y ésteres de ácidos grasos poliinsaturados para el tratamiento de enfermedades cardiovasculares.
US20130196990A1 (en) 2010-10-06 2013-08-01 Junya Qu Benzimidazole Derivatives As PI3 Kinase Inhibitors
CN102138920A (zh) * 2011-02-24 2011-08-03 海南中济医药科技有限公司 一种含有坎地沙坦酯和氢氯噻嗪的药物组合物及其制备方法
CN102357095A (zh) * 2011-07-12 2012-02-22 迪沙药业集团有限公司 稳定的药物组合物
CA2853024C (en) 2011-11-11 2017-08-22 Pfizer Inc. 2-thiopyrimidinones
JP6272328B2 (ja) * 2012-12-05 2018-01-31 沢井製薬株式会社 カンデサルタンシレキセチル含有製剤
PL236001B1 (pl) 2012-12-21 2020-11-30 Adamed Spolka Z Ograniczona Odpowiedzialnoscia Złożona kompozycja farmaceutyczna zawierająca kandesartan cyleksetylu oraz amlodypinę, sposób jej wytwarzania oraz jednostkowa postać dawkowania zawierająca tę kompozycję
US9603804B2 (en) 2013-04-25 2017-03-28 Kyorin Pharmaceutical Co., Ltd. Solid pharmaceutical composition
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Also Published As

Publication number Publication date
ES2104797T3 (es) 1997-10-16
CA2083305C (en) 2003-12-09
AU2839192A (en) 1993-05-27
KR930009606A (ko) 1993-06-21
MX9206634A (es) 1993-05-31
EP1468683A2 (en) 2004-10-20
EP0546358A2 (en) 1993-06-16
FI925270A0 (fi) 1992-11-19
NO924417L (no) 1993-05-21
DE69221831T2 (de) 1998-01-02
FI20030210A (fi) 2003-02-12
DE69233424T2 (de) 2005-02-17
AU659691B2 (en) 1995-05-25
HU211608A9 (en) 1995-12-28
DK0546358T3 (da) 1998-03-09
BR1100336A (pt) 2000-04-18
US5534534A (en) 1996-07-09
KR100256633B1 (ko) 2000-05-15
EP0546358B1 (en) 1997-08-27
NO924417D0 (no) 1992-11-16
NZ245175A (en) 1994-07-26
FI925270A (fi) 1993-05-21
EP0782852A1 (en) 1997-07-09
ATE157248T1 (de) 1997-09-15
CN1072338A (zh) 1993-05-26
DE69221831D1 (de) 1997-10-02
CN1047518C (zh) 1999-12-22
EP1468683A3 (en) 2012-06-06
NO304408B1 (no) 1998-12-14
TW284688B (el) 1996-09-01
DE69233424D1 (de) 2004-11-04
ATE277602T1 (de) 2004-10-15
EP0782852B1 (en) 2004-09-29
CA2083305A1 (en) 1993-05-21
FI111604B (fi) 2003-08-29
EP0546358A3 (el) 1994-03-30

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