DE69218977T2 - Trifluoromethylketon-Tripeptidderivate - Google Patents

Trifluoromethylketon-Tripeptidderivate

Info

Publication number
DE69218977T2
DE69218977T2 DE69218977T DE69218977T DE69218977T2 DE 69218977 T2 DE69218977 T2 DE 69218977T2 DE 69218977 T DE69218977 T DE 69218977T DE 69218977 T DE69218977 T DE 69218977T DE 69218977 T2 DE69218977 T2 DE 69218977T2
Authority
DE
Germany
Prior art keywords
pharmaceutically acceptable
compound
salt
valyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69218977T
Other languages
German (de)
English (en)
Other versions
DE69218977D1 (de
Inventor
Keiji Hemmi
Keisuke Imai
Ichiro Shima
Hirokazu Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909028231A external-priority patent/GB9028231D0/en
Priority claimed from GB919119713A external-priority patent/GB9119713D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of DE69218977D1 publication Critical patent/DE69218977D1/de
Application granted granted Critical
Publication of DE69218977T2 publication Critical patent/DE69218977T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Magnetically Actuated Valves (AREA)
  • Control Of Throttle Valves Provided In The Intake System Or In The Exhaust System (AREA)
  • Pyrrole Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Hydrogenated Pyridines (AREA)
DE69218977T 1990-12-31 1992-01-02 Trifluoromethylketon-Tripeptidderivate Expired - Lifetime DE69218977T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909028231A GB9028231D0 (en) 1990-12-31 1990-12-31 Trifluoromethylketone derivatives,processes for preparation thereof and use thereof
GB919119713A GB9119713D0 (en) 1991-09-16 1991-09-16 Trifluoremethylketone derivatives, processes for preparation thereof and use thereof

Publications (2)

Publication Number Publication Date
DE69218977D1 DE69218977D1 (de) 1997-05-22
DE69218977T2 true DE69218977T2 (de) 1997-08-07

Family

ID=26298196

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69218977T Expired - Lifetime DE69218977T2 (de) 1990-12-31 1992-01-02 Trifluoromethylketon-Tripeptidderivate

Country Status (19)

Country Link
US (2) US5296591A (enExample)
EP (1) EP0494071B1 (enExample)
JP (1) JPH0699378B2 (enExample)
KR (1) KR100192991B1 (enExample)
CN (1) CN1040003C (enExample)
AT (1) ATE151775T1 (enExample)
AU (1) AU641577B2 (enExample)
CA (1) CA2058560C (enExample)
DE (1) DE69218977T2 (enExample)
DK (1) DK0494071T3 (enExample)
ES (1) ES2099755T3 (enExample)
FI (1) FI106379B (enExample)
GR (1) GR3023719T3 (enExample)
HU (2) HU210263B (enExample)
IE (1) IE914360A1 (enExample)
MX (1) MX9102612A (enExample)
NO (1) NO309274B1 (enExample)
RU (1) RU2073684C1 (enExample)
SG (1) SG50457A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
FR2694295B1 (fr) * 1992-07-28 1994-09-02 Adir Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
FR2719589B1 (fr) * 1994-05-05 1996-06-14 Adir Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
NZ287604A (en) * 1994-06-02 1998-12-23 Merrell Pharma Inc Acylated enol derivatives as prodrugs of elastase inhibitors
AU690986B2 (en) * 1994-06-02 1998-05-07 Merrell Pharmaceuticals Inc. Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
JP2002161051A (ja) * 1996-12-24 2002-06-04 Fujisawa Pharmaceut Co Ltd 脳虚血性疾患等の治療剤
US6610748B1 (en) * 1998-02-24 2003-08-26 Fujisawa Pharmaceutical Co., Ltd. Preventives/remedies for skin aging
US20020045231A1 (en) * 1999-02-02 2002-04-18 Napper Andrew D. Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies
AU7453700A (en) * 1999-10-12 2001-04-23 Fujisawa Pharmaceutical Co., Ltd. Remedies for intractable wound
IL148924A (en) * 2002-03-26 2015-06-30 Mor Research Applic Ltd Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases
DE10219464A1 (de) 2002-04-30 2003-11-13 Focke & Co Zigarettenpackung
SE0202462D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel use
EP2019837B1 (en) * 2006-05-23 2011-03-23 Irm Llc Compounds and compositions as channel activating protease inhibitors
JP4101276B2 (ja) * 2006-08-25 2008-06-18 株式会社ステリック再生医科学研究所 慢性閉塞性肺疾患改善剤
MX2009005252A (es) * 2006-11-17 2009-05-28 Abbott Lab Aminopirrolidinas como antagonistas del receptor de quimiocina.
ES2749504T3 (es) 2009-10-13 2020-03-20 Ligand Pharm Inc Compuestos de moléculas pequeñas miméticos del factor de crecimiento hematopoyético y sus usos
RU2670982C2 (ru) 2013-05-08 2018-10-29 Киссеи Фармасьютикал Ко., Лтд. ПРОИЗВОДНЫЕ α-ЗАМЕЩЕННОГО ГЛИЦИНАМИДА
CN104650016A (zh) * 2015-01-29 2015-05-27 武汉大学 拟三肽类化合物及其制备方法
KR102431188B1 (ko) * 2016-06-24 2022-08-10 포라 가세이 고교 가부시키가이샤 주름개선용 피부외용제
US20200368131A1 (en) 2017-11-15 2020-11-26 Pola Chemical Industries, Inc. Oil-based composition
CN119241385B (zh) * 2024-11-29 2025-03-25 江西师范大学 β-酰氧基烯酰胺衍生物及其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8600263D0 (en) * 1985-01-22 1986-02-12 Ici America Inc Peptide derivatives
EP0276101A3 (en) * 1987-01-19 1989-11-23 Ici Americas Inc. Substituted peptide derivatives
EP0369391A3 (en) * 1988-11-15 1991-09-25 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof

Also Published As

Publication number Publication date
ES2099755T3 (es) 1997-06-01
NO920035D0 (no) 1992-01-02
HU914153D0 (en) 1992-03-30
JPH04297446A (ja) 1992-10-21
DE69218977D1 (de) 1997-05-22
HUT60507A (en) 1992-09-28
AU641577B2 (en) 1993-09-23
KR100192991B1 (ko) 1999-06-15
US5430025A (en) 1995-07-04
RU2073684C1 (ru) 1997-02-20
US5296591A (en) 1994-03-22
FI915996A0 (fi) 1991-12-19
HU211943A9 (en) 1996-01-29
DK0494071T3 (enExample) 1997-05-12
GR3023719T3 (en) 1997-09-30
ATE151775T1 (de) 1997-05-15
EP0494071A3 (en) 1993-05-05
JPH0699378B2 (ja) 1994-12-07
EP0494071B1 (en) 1997-04-16
CN1063108A (zh) 1992-07-29
KR920011988A (ko) 1992-07-25
SG50457A1 (en) 1998-07-20
HU210263B (en) 1995-03-28
MX9102612A (es) 1992-06-01
EP0494071A2 (en) 1992-07-08
NO920035L (no) 1992-07-01
CN1040003C (zh) 1998-09-30
FI106379B (fi) 2001-01-31
AU8985391A (en) 1992-07-02
CA2058560C (en) 2000-12-12
FI915996L (fi) 1992-07-01
IE914360A1 (en) 1992-07-01
CA2058560A1 (en) 1992-07-01
NO309274B1 (no) 2001-01-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTELLAS PHARMA INC., TOKIO/TOKYO, JP