CN1040003C - 三氟甲基酮衍生物的制备方法 - Google Patents

三氟甲基酮衍生物的制备方法 Download PDF

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Publication number
CN1040003C
CN1040003C CN91112615A CN91112615A CN1040003C CN 1040003 C CN1040003 C CN 1040003C CN 91112615 A CN91112615 A CN 91112615A CN 91112615 A CN91112615 A CN 91112615A CN 1040003 C CN1040003 C CN 1040003C
Authority
CN
China
Prior art keywords
compound
salt
following formula
amino
valyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN91112615A
Other languages
English (en)
Chinese (zh)
Other versions
CN1063108A (zh
Inventor
逸见惠次
一郎
今井启佑
田中洋和
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Inc
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909028231A external-priority patent/GB9028231D0/en
Priority claimed from GB919119713A external-priority patent/GB9119713D0/en
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Publication of CN1063108A publication Critical patent/CN1063108A/zh
Application granted granted Critical
Publication of CN1040003C publication Critical patent/CN1040003C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Magnetically Actuated Valves (AREA)
  • Control Of Throttle Valves Provided In The Intake System Or In The Exhaust System (AREA)
  • Pyrrole Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Hydrogenated Pyridines (AREA)
CN91112615A 1990-12-31 1991-12-30 三氟甲基酮衍生物的制备方法 Expired - Lifetime CN1040003C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB9028231.0 1990-12-31
GB909028231A GB9028231D0 (en) 1990-12-31 1990-12-31 Trifluoromethylketone derivatives,processes for preparation thereof and use thereof
GB9119713.7 1991-09-16
GB919119713A GB9119713D0 (en) 1991-09-16 1991-09-16 Trifluoremethylketone derivatives, processes for preparation thereof and use thereof

Publications (2)

Publication Number Publication Date
CN1063108A CN1063108A (zh) 1992-07-29
CN1040003C true CN1040003C (zh) 1998-09-30

Family

ID=26298196

Family Applications (1)

Application Number Title Priority Date Filing Date
CN91112615A Expired - Lifetime CN1040003C (zh) 1990-12-31 1991-12-30 三氟甲基酮衍生物的制备方法

Country Status (19)

Country Link
US (2) US5296591A (enExample)
EP (1) EP0494071B1 (enExample)
JP (1) JPH0699378B2 (enExample)
KR (1) KR100192991B1 (enExample)
CN (1) CN1040003C (enExample)
AT (1) ATE151775T1 (enExample)
AU (1) AU641577B2 (enExample)
CA (1) CA2058560C (enExample)
DE (1) DE69218977T2 (enExample)
DK (1) DK0494071T3 (enExample)
ES (1) ES2099755T3 (enExample)
FI (1) FI106379B (enExample)
GR (1) GR3023719T3 (enExample)
HU (2) HU210263B (enExample)
IE (1) IE914360A1 (enExample)
MX (1) MX9102612A (enExample)
NO (1) NO309274B1 (enExample)
RU (1) RU2073684C1 (enExample)
SG (1) SG50457A1 (enExample)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US5714470A (en) * 1991-08-22 1998-02-03 Merrell Pharmaceuticals, Inc. Orally-active elastase inhibitors
US5478811A (en) * 1991-08-22 1995-12-26 Merrell Dow Pharmaceuticals Inc. Orally-active elastase inhibitors
FR2694295B1 (fr) * 1992-07-28 1994-09-02 Adir Nouveaux peptides dérivés de trifluoromethylcetones, leur procéde de préparation et les compositions pharmaceutiques qui les contiennent.
FR2719589B1 (fr) * 1994-05-05 1996-06-14 Adir Nouveaux peptides dérivés de trifluorométhylcétones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
NZ287604A (en) * 1994-06-02 1998-12-23 Merrell Pharma Inc Acylated enol derivatives as prodrugs of elastase inhibitors
AU690986B2 (en) * 1994-06-02 1998-05-07 Merrell Pharmaceuticals Inc. Perfluoroalkyl ketone inhibitors of elastase and processes for making the same
US6172044B1 (en) 1995-12-01 2001-01-09 Aventis Pharmaceuticals Inc. Acylated enol derivative of α-ketoesters and α-ketoamides
US5948886A (en) * 1996-11-20 1999-09-07 Hoechst Marion Roussel, Inc. Acylated enol derivatives of α-ketoesters and α-ketoamides
JP2002161051A (ja) * 1996-12-24 2002-06-04 Fujisawa Pharmaceut Co Ltd 脳虚血性疾患等の治療剤
US6610748B1 (en) * 1998-02-24 2003-08-26 Fujisawa Pharmaceutical Co., Ltd. Preventives/remedies for skin aging
US20020045231A1 (en) * 1999-02-02 2002-04-18 Napper Andrew D. Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies
AU7453700A (en) * 1999-10-12 2001-04-23 Fujisawa Pharmaceutical Co., Ltd. Remedies for intractable wound
IL148924A (en) * 2002-03-26 2015-06-30 Mor Research Applic Ltd Use of substances that inhibit intracellular elastase activity in the preparation of a drug for the treatment and / or prevention of necrosis of cells and related diseases
DE10219464A1 (de) 2002-04-30 2003-11-13 Focke & Co Zigarettenpackung
SE0202462D0 (sv) * 2002-08-14 2002-08-14 Astrazeneca Ab Novel use
EP2019837B1 (en) * 2006-05-23 2011-03-23 Irm Llc Compounds and compositions as channel activating protease inhibitors
JP4101276B2 (ja) * 2006-08-25 2008-06-18 株式会社ステリック再生医科学研究所 慢性閉塞性肺疾患改善剤
MX2009005252A (es) * 2006-11-17 2009-05-28 Abbott Lab Aminopirrolidinas como antagonistas del receptor de quimiocina.
ES2749504T3 (es) 2009-10-13 2020-03-20 Ligand Pharm Inc Compuestos de moléculas pequeñas miméticos del factor de crecimiento hematopoyético y sus usos
RU2670982C2 (ru) 2013-05-08 2018-10-29 Киссеи Фармасьютикал Ко., Лтд. ПРОИЗВОДНЫЕ α-ЗАМЕЩЕННОГО ГЛИЦИНАМИДА
CN104650016A (zh) * 2015-01-29 2015-05-27 武汉大学 拟三肽类化合物及其制备方法
KR102431188B1 (ko) * 2016-06-24 2022-08-10 포라 가세이 고교 가부시키가이샤 주름개선용 피부외용제
US20200368131A1 (en) 2017-11-15 2020-11-26 Pola Chemical Industries, Inc. Oil-based composition
CN119241385B (zh) * 2024-11-29 2025-03-25 江西师范大学 β-酰氧基烯酰胺衍生物及其制备方法和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189305A2 (en) * 1985-01-22 1986-07-30 Ici Americas Inc. Peptide derivatives
EP0276101A2 (en) * 1987-01-19 1988-07-27 Ici Americas Inc. Substituted peptide derivatives
EP0369391A2 (en) * 1988-11-15 1990-05-23 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5221665A (en) * 1989-10-27 1993-06-22 Boehringer Ingelheim Pharmaceuticals, Inc. N-substituted amides
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0189305A2 (en) * 1985-01-22 1986-07-30 Ici Americas Inc. Peptide derivatives
EP0276101A2 (en) * 1987-01-19 1988-07-27 Ici Americas Inc. Substituted peptide derivatives
EP0369391A2 (en) * 1988-11-15 1990-05-23 Boehringer Ingelheim Pharmaceuticals Inc. N-substituted amides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
RES.COMMVN.CHEN.PATHOL.PHARM.VOL.68,NO.3 1990.6.1 J.W.SKILES"INHIBITON OF HLE BY N-SUB-STIFUTED TNMIPEPTIDE TNIFLUONOMEFHYL *

Also Published As

Publication number Publication date
ES2099755T3 (es) 1997-06-01
NO920035D0 (no) 1992-01-02
HU914153D0 (en) 1992-03-30
JPH04297446A (ja) 1992-10-21
DE69218977D1 (de) 1997-05-22
HUT60507A (en) 1992-09-28
AU641577B2 (en) 1993-09-23
KR100192991B1 (ko) 1999-06-15
US5430025A (en) 1995-07-04
RU2073684C1 (ru) 1997-02-20
US5296591A (en) 1994-03-22
FI915996A0 (fi) 1991-12-19
HU211943A9 (en) 1996-01-29
DK0494071T3 (enExample) 1997-05-12
GR3023719T3 (en) 1997-09-30
ATE151775T1 (de) 1997-05-15
EP0494071A3 (en) 1993-05-05
JPH0699378B2 (ja) 1994-12-07
DE69218977T2 (de) 1997-08-07
EP0494071B1 (en) 1997-04-16
CN1063108A (zh) 1992-07-29
KR920011988A (ko) 1992-07-25
SG50457A1 (en) 1998-07-20
HU210263B (en) 1995-03-28
MX9102612A (es) 1992-06-01
EP0494071A2 (en) 1992-07-08
NO920035L (no) 1992-07-01
FI106379B (fi) 2001-01-31
AU8985391A (en) 1992-07-02
CA2058560C (en) 2000-12-12
FI915996L (fi) 1992-07-01
IE914360A1 (en) 1992-07-01
CA2058560A1 (en) 1992-07-01
NO309274B1 (no) 2001-01-08

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C15 Extension of patent right duration from 15 to 20 years for appl. with date before 31.12.1992 and still valid on 11.12.2001 (patent law change 1993)
OR01 Other related matters
C56 Change in the name or address of the patentee

Owner name: ASTELLAS PHARMA INC.

Free format text: FORMER NAME OR ADDRESS: FUJISAWA PHARMACEUTICAL CO., LTD.

CP03 Change of name, title or address

Address after: Tokyo, Japan

Patentee after: Yamanouchi Pharma Co., Ltd.

Address before: Osaka City, Osaka of Japan

Patentee before: Fujisawa Pharmaceutical Co., Ltd.

C17 Cessation of patent right
CX01 Expiry of patent term

Expiration termination date: 20111230

Granted publication date: 19980930