DE69129333T2 - Diphenylpiperazinderivat und dieses enthaltendes arzneimittel für kreislauforgane - Google Patents

Diphenylpiperazinderivat und dieses enthaltendes arzneimittel für kreislauforgane

Info

Publication number
DE69129333T2
DE69129333T2 DE69129333T DE69129333T DE69129333T2 DE 69129333 T2 DE69129333 T2 DE 69129333T2 DE 69129333 T DE69129333 T DE 69129333T DE 69129333 T DE69129333 T DE 69129333T DE 69129333 T2 DE69129333 T2 DE 69129333T2
Authority
DE
Germany
Prior art keywords
group
carbon atoms
hydroxy
piperazine
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69129333T
Other languages
German (de)
English (en)
Other versions
DE69129333D1 (de
Inventor
Kazunori Pola Pharmaceutical R&D Yokohama-Shi Kanagawa 244 Harada
Masato Pola Pharmaceutical R&D Laboratory Yokohama-Shi Kanagawa 244 Inazu
Tetsuo Pola Pharmaceutical R&D Laboratory Kanagawa 244 Katoh
Nobuyuki Pola Pharmaceutical R&D Yokohama-Shi Kanagawa 244 Kawakatsu
Makoto Pola Pharmaceutical R&D Laboratory Kanagawa 244 Kimura
Yoshiyuki Totsuka-Ku Yokohama-Shi Kanagawa 244 Miyata
Yoshiharu Pola Pharmaceutical R&D Yokohama-Shi Kanagawa 244 Momota
Toshihiro Pola Pharmaceutical R&D Yokohama-Shi Kanagawa 244 Morimoto
Takayuki Pola Pharmaceutical R&D Kanagawa 244 Namiki
Takeshi Pola Pharmaceutical R&D Yokohama-Shi Kanagawa 244 Yamamoto
Masayuki Pola Pharmaceutical R&D Yokohama-Shi Kanagawa 244 Yanagi
Ryoko Pola Pharmaceutical R&D Laboratory Kanagawa 244 Yokota
Yuji Pola Pharmaceutical R&D Laboratory Kanagawa 244 Yoshiko
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pola Orbis Holdings Inc
Original Assignee
Pola Chemical Industries Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Chemical Industries Inc filed Critical Pola Chemical Industries Inc
Application granted granted Critical
Publication of DE69129333D1 publication Critical patent/DE69129333D1/de
Publication of DE69129333T2 publication Critical patent/DE69129333T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69129333T 1990-09-13 1991-09-13 Diphenylpiperazinderivat und dieses enthaltendes arzneimittel für kreislauforgane Expired - Fee Related DE69129333T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP24352690 1990-09-13
PCT/JP1991/001227 WO1992005165A1 (en) 1990-09-13 1991-09-13 Diphenylpiperazine derivative and drug for circulatory organ containing the same

Publications (2)

Publication Number Publication Date
DE69129333D1 DE69129333D1 (de) 1998-06-04
DE69129333T2 true DE69129333T2 (de) 1998-08-20

Family

ID=17105216

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69129333T Expired - Fee Related DE69129333T2 (de) 1990-09-13 1991-09-13 Diphenylpiperazinderivat und dieses enthaltendes arzneimittel für kreislauforgane

Country Status (11)

Country Link
US (1) US5391552A (enExample)
EP (2) EP0549796B1 (enExample)
JP (1) JP3101677B2 (enExample)
KR (1) KR0173141B1 (enExample)
AT (1) ATE165600T1 (enExample)
AU (1) AU654969B2 (enExample)
CA (1) CA2091248C (enExample)
DE (1) DE69129333T2 (enExample)
ES (1) ES2117013T3 (enExample)
TW (1) TW205034B (enExample)
WO (1) WO1992005165A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3831993A1 (de) * 1988-09-21 1990-03-29 Basf Ag 2-hydroxy-3-phenoxy-propyl-substituierte piperazine und homo-piperazine, ihre herstellung und verwendung
DE69426771T2 (de) * 1993-06-25 2001-06-13 Pola Chemical Industries, Inc. Dopaminreinkorporationshemmer zur behandlung des parkinsonschen syndroms
DE4404249C2 (de) * 1994-02-10 2001-10-18 Basf Ag Substituierte Cycloalkyl-piperazinyl-ethanol, ihre Herstellung und diese enthaltende Arzneimittel
JP3571114B2 (ja) * 1995-07-11 2004-09-29 ポーラ化成工業株式会社 麻薬拮抗剤
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US7186726B2 (en) * 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
US20040266784A1 (en) * 1998-06-30 2004-12-30 Snutch Terrance P. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6011035A (en) * 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
US6951862B2 (en) * 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
CA2562371A1 (en) * 2004-04-09 2005-10-20 Neuromed Pharmaceuticals Ltd. Diarylamine derivatives as calcium channel blockers
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
WO2007133481A2 (en) * 2006-05-11 2007-11-22 Neuromed Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
WO2012122279A1 (en) 2011-03-08 2012-09-13 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
AU2017340403B2 (en) * 2016-10-05 2022-03-17 The United States as Represented by the Department of Veterans Affairs Small molecule AMPK activators
AU2020345766A1 (en) 2019-09-10 2022-03-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for increasing level of phosphorylated AMPK protein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025111B1 (en) * 1979-08-10 1984-07-25 Sandoz Ag 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3600390A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
DE3723648A1 (de) * 1987-07-17 1989-01-26 Sandoz Ag Indol-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3831993A1 (de) * 1988-09-21 1990-03-29 Basf Ag 2-hydroxy-3-phenoxy-propyl-substituierte piperazine und homo-piperazine, ihre herstellung und verwendung

Also Published As

Publication number Publication date
CA2091248A1 (en) 1992-03-14
AU8491691A (en) 1992-04-15
ATE165600T1 (de) 1998-05-15
EP0549796A1 (en) 1993-07-07
KR930702321A (ko) 1993-09-08
EP0549796B1 (en) 1998-04-29
TW205034B (enExample) 1993-05-01
EP0549796A4 (en) 1993-09-29
AU654969B2 (en) 1994-12-01
KR0173141B1 (ko) 1999-02-01
ES2117013T3 (es) 1998-08-01
DE69129333D1 (de) 1998-06-04
EP0612738A1 (en) 1994-08-31
WO1992005165A1 (en) 1992-04-02
CA2091248C (en) 2002-11-05
JP3101677B2 (ja) 2000-10-23
US5391552A (en) 1995-02-21

Similar Documents

Publication Publication Date Title
DE3787688T2 (de) Diamin-Verbindungen.
DE69823648T2 (de) 1-phenyl-4-benzylpiperazine: spezifische liganden für den dopamin rezeptor (d4)
DE2928485A1 (de) Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen
US5391552A (en) Diphenylpiperazine derivative and drug for circulatory organ containing the same
CH641159A5 (de) Verfahren zur herstellung von neuen guanidinderivaten.
JPWO1992005165A1 (ja) ジフェニルピペラジン誘導体及びこれを含有する循環器用薬
DE68911699T2 (de) Diamin-Verbindungen.
DE2712023A1 (de) Sulfonamidoaminobenzoesaeurederivate, solche enthaltende arzneimittel sowie verfahren zur herstellung derselben
CH642066A5 (de) 3-indolyl-tert.-butylaminopropanole, verfahren zu deren herstellung und sie enthaltende pharmazeutische mittel.
DE2523103A1 (de) Neue propargyl-2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
CH623044A5 (en) Process for the preparation of novel anilino-2-oxazolines
DE2623846A1 (de) 4-chinazolinyl-guanidine und verfahren zu ihrer herstellung
DE2308883A1 (de) Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE3723648A1 (de) Indol-derivate, ihre herstellung und sie enthaltende arzneimittel
CH642057A5 (en) Benzenesulphonamide and benzamide derivatives and their preparation
DE2509168A1 (de) Neue nitroimidazole
DE2514334A1 (de) Neue pyridinderivate, verfahren zu deren herstellung und ihre verwendung in pharmazeutischen zusammensetzungen
DE3879378T2 (de) Amid-verbindungen.
DE1915230B2 (de) Hydroxyphenylalkylaminderivate, verfahren zu deren herstellung und arzneimittel auf deren basis
AT389872B (de) Verfahren zur herstellung von neuen substituierten 2-phenylmethylen-1aminoalkyloximinocycloalkanen und deren saeureadditionssalzen
EP0000727B1 (de) 3-(4-(1,3-Diazacycloalken-2-yl)-phenyl)-1,2-benzisothiazole, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel.
DE1913178A1 (de) 2-(alpha-Morpholinobenzyl)-anilide und Verfahren zu ihrer Herstellung
EP0011092A1 (de) Alpha-Aminophenylessigsäurederivate zur Verwendung bei der Behandlung von Entzündungen sowie neue alpha-Aminophenylessigsäurederivate
EP0004904B1 (de) 2-Amino-3a,4,5,6-tetrahydro-perimidin-Derivate, diese enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
AT368146B (de) Verfahren zur herstellung neuer 2-anilinooxazoline

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee