TW205034B - - Google Patents

Download PDF

Info

Publication number
TW205034B
TW205034B TW080107221A TW80107221A TW205034B TW 205034 B TW205034 B TW 205034B TW 080107221 A TW080107221 A TW 080107221A TW 80107221 A TW80107221 A TW 80107221A TW 205034 B TW205034 B TW 205034B
Authority
TW
Taiwan
Prior art keywords
compound
bis
butyl
fluorophenyl
trap
Prior art date
Application number
TW080107221A
Other languages
English (en)
Chinese (zh)
Original Assignee
Pola Kasei Kogyo Kk
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pola Kasei Kogyo Kk filed Critical Pola Kasei Kogyo Kk
Application granted granted Critical
Publication of TW205034B publication Critical patent/TW205034B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
TW080107221A 1990-09-13 1991-09-12 TW205034B (enExample)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP24352690 1990-09-13

Publications (1)

Publication Number Publication Date
TW205034B true TW205034B (enExample) 1993-05-01

Family

ID=17105216

Family Applications (1)

Application Number Title Priority Date Filing Date
TW080107221A TW205034B (enExample) 1990-09-13 1991-09-12

Country Status (11)

Country Link
US (1) US5391552A (enExample)
EP (2) EP0549796B1 (enExample)
JP (1) JP3101677B2 (enExample)
KR (1) KR0173141B1 (enExample)
AT (1) ATE165600T1 (enExample)
AU (1) AU654969B2 (enExample)
CA (1) CA2091248C (enExample)
DE (1) DE69129333T2 (enExample)
ES (1) ES2117013T3 (enExample)
TW (1) TW205034B (enExample)
WO (1) WO1992005165A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3831993A1 (de) * 1988-09-21 1990-03-29 Basf Ag 2-hydroxy-3-phenoxy-propyl-substituierte piperazine und homo-piperazine, ihre herstellung und verwendung
DE69426771T2 (de) * 1993-06-25 2001-06-13 Pola Chemical Industries, Inc. Dopaminreinkorporationshemmer zur behandlung des parkinsonschen syndroms
DE4404249C2 (de) * 1994-02-10 2001-10-18 Basf Ag Substituierte Cycloalkyl-piperazinyl-ethanol, ihre Herstellung und diese enthaltende Arzneimittel
JP3571114B2 (ja) * 1995-07-11 2004-09-29 ポーラ化成工業株式会社 麻薬拮抗剤
US20060084660A1 (en) * 1998-06-30 2006-04-20 Neuromed Technologies Inc. Calcium channel blockers comprising two benzhydril moieties
US7186726B2 (en) * 1998-06-30 2007-03-06 Neuromed Pharmaceuticals Ltd. Preferentially substituted calcium channel blockers
US20040266784A1 (en) * 1998-06-30 2004-12-30 Snutch Terrance P. Calcium channel inhibitors comprising benzhydril spaced from piperazine
US6011035A (en) * 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
US6951862B2 (en) * 1998-06-30 2005-10-04 Neuromed Technologies, Inc. Calcium channel blockers comprising two benzhydril moieties
US20040259866A1 (en) * 1998-06-30 2004-12-23 Snutch Terrance P. Calcium channel blockers comprising two benzhydril moieties
CA2562371A1 (en) * 2004-04-09 2005-10-20 Neuromed Pharmaceuticals Ltd. Diarylamine derivatives as calcium channel blockers
US20050227999A1 (en) * 2004-04-09 2005-10-13 Neuromed Technologies Inc. Diarylamine derivatives as calcium channel blockers
WO2007133481A2 (en) * 2006-05-11 2007-11-22 Neuromed Pharmaceuticals Ltd. Method for increasing the bioavailability of benzhydryl piperazine containing compounds
US8409560B2 (en) 2011-03-08 2013-04-02 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
WO2012122279A1 (en) 2011-03-08 2012-09-13 Zalicus Pharmaceuticals Ltd. Solid dispersion formulations and methods of use thereof
AU2017340403B2 (en) * 2016-10-05 2022-03-17 The United States as Represented by the Department of Veterans Affairs Small molecule AMPK activators
AU2020345766A1 (en) 2019-09-10 2022-03-03 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for increasing level of phosphorylated AMPK protein

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0025111B1 (en) * 1979-08-10 1984-07-25 Sandoz Ag 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them
DE3200304A1 (de) * 1981-01-16 1982-08-26 Sandoz-Patent-GmbH, 7850 Lörrach 3-aminopropoxyaryl-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3600390A1 (de) * 1986-01-09 1987-07-16 Hoechst Ag Diarylalkyl-substituierte alkylamine, verfahren zu ihrer herstellung, ihre verwendung sowie sie enthaltende arzneimittel
DE3723648A1 (de) * 1987-07-17 1989-01-26 Sandoz Ag Indol-derivate, ihre herstellung und sie enthaltende arzneimittel
DE3831993A1 (de) * 1988-09-21 1990-03-29 Basf Ag 2-hydroxy-3-phenoxy-propyl-substituierte piperazine und homo-piperazine, ihre herstellung und verwendung

Also Published As

Publication number Publication date
CA2091248A1 (en) 1992-03-14
AU8491691A (en) 1992-04-15
ATE165600T1 (de) 1998-05-15
EP0549796A1 (en) 1993-07-07
KR930702321A (ko) 1993-09-08
EP0549796B1 (en) 1998-04-29
EP0549796A4 (en) 1993-09-29
AU654969B2 (en) 1994-12-01
KR0173141B1 (ko) 1999-02-01
DE69129333T2 (de) 1998-08-20
ES2117013T3 (es) 1998-08-01
DE69129333D1 (de) 1998-06-04
EP0612738A1 (en) 1994-08-31
WO1992005165A1 (en) 1992-04-02
CA2091248C (en) 2002-11-05
JP3101677B2 (ja) 2000-10-23
US5391552A (en) 1995-02-21

Similar Documents

Publication Publication Date Title
US5786355A (en) 4,6-diarylpyrimidine derivatives and salts thereof
CA3161892A1 (en) Combinations of estrogen receptor degraders and cyclin-dependent kinase inhibitors for treating cancer
MX2014014582A (es) Inhibidores pirazolopirimidona y pirazolopiridona de tanquirasa.
CZ200036A3 (cs) Triazolové sloučeniny a jejich použití
CA2682393A1 (en) 5-membered heterocyclic derivative and use thereof for medical purposes
JPS6215546B2 (enExample)
FR2735127A1 (fr) Nouvelles piperazines heteroaromatiques utiles comme medicaments.
CA2091248C (en) Diphenylpiperazine derivative and drug for circulatory organ containing the same
IT8348746A1 (it) Derivati amminometil-benzenici arili-sostituiti ad attività regolatrice del ritmo cardiaco e composizioni che li contengono
TW445263B (en) Novel esters of 1,4-disubstituted piperidine derivatives
MXPA02006499A (es) Derivados de fenilpiperazinilo.
JPWO1992005165A1 (ja) ジフェニルピペラジン誘導体及びこれを含有する循環器用薬
TW426674B (en) New 2-(3H)-oxazolone derivatives
CA2929188C (en) Quinazoline derivatives as tam family kinase inhibitors
KR20250023339A (ko) 페닐 트라이아졸 mll1-wdr5 단백질-단백질 상호작용 저해제
EA010392B1 (ru) Производные имидазолов, способ их получения и их применение в качестве лекарственного средства
RU2737085C2 (ru) Новое соединение 2,4,6-тризамещенного s-триазина, способ его получения и его применение
CA2022236A1 (en) Coumarin derivatives, their preparation and their use in the treatment of cerebrovascular disorders
CN114478509B (zh) 五元杂环取代的苯甲酰胺类化合物及其制备方法与应用
KR20110005722A (ko) Ｃｂ1-길항 활성을 갖는 (5ｒ)-1,5-디아릴-4,5-디하이드로-1ｈ-피라졸-3-카복스아미딘 유도체
JPH0232071A (ja) フエノチアジンの新規誘導体類、それらの製法、およびそれらを含有している組成物
JPH04217945A (ja) 置換アルキルベンゼン誘導体およびそれを含有する抗潰瘍剤
JPS59106443A (ja) フエニルプロパノ−ルアミン、その製造及び使用
CN110804025B (zh) 一种卤代苯异噁唑衍生物及其制备方法与应用
IE41667B1 (en) Substituted phenylpiperazine compounds and pharmaceutical uses thereof