DE69121742D1 - Verfahren zur Herstellung von Somatotropinmonomeren in reiner Form - Google Patents
Verfahren zur Herstellung von Somatotropinmonomeren in reiner FormInfo
- Publication number
- DE69121742D1 DE69121742D1 DE69121742T DE69121742T DE69121742D1 DE 69121742 D1 DE69121742 D1 DE 69121742D1 DE 69121742 T DE69121742 T DE 69121742T DE 69121742 T DE69121742 T DE 69121742T DE 69121742 D1 DE69121742 D1 DE 69121742D1
- Authority
- DE
- Germany
- Prior art keywords
- somatotropin
- monomers
- somatotropin monomers
- solution
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000018997 Growth Hormone Human genes 0.000 title abstract 5
- 108010051696 Growth Hormone Proteins 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000000178 monomer Substances 0.000 title abstract 4
- 238000000746 purification Methods 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 239000002510 pyrogen Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 230000007928 solubilization Effects 0.000 abstract 1
- 238000005063 solubilization Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Epoxy Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/486,476 US5182369A (en) | 1990-02-28 | 1990-02-28 | Method for purifying somatotropin monomers |
Publications (1)
Publication Number | Publication Date |
---|---|
DE69121742D1 true DE69121742D1 (de) | 1996-10-10 |
Family
ID=23932038
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69121742T Expired - Lifetime DE69121742D1 (de) | 1990-02-28 | 1991-02-27 | Verfahren zur Herstellung von Somatotropinmonomeren in reiner Form |
Country Status (11)
Country | Link |
---|---|
US (2) | US5182369A (de) |
EP (1) | EP0445099B1 (de) |
JP (1) | JP2798531B2 (de) |
AT (1) | ATE142227T1 (de) |
AU (1) | AU633699B2 (de) |
CA (1) | CA2037244C (de) |
DE (1) | DE69121742D1 (de) |
IE (1) | IE77159B1 (de) |
IL (1) | IL97376A (de) |
NZ (1) | NZ237240A (de) |
ZA (1) | ZA911448B (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5182369A (en) * | 1990-02-28 | 1993-01-26 | Monsanto Company | Method for purifying somatotropin monomers |
AU7877194A (en) * | 1993-09-22 | 1995-04-10 | American Cyanamid Company | Porcine somatotropin having enhanced stability; process for producing |
AU2592395A (en) * | 1994-05-19 | 1995-12-18 | Monsanto Company | Method for purifying somatotropin monomers |
ZA9711733B (en) | 1996-12-31 | 1998-07-01 | Monsanto Co | Method for solubilization and naturation of somatotropins |
CA2338319A1 (en) | 1998-07-21 | 2000-02-03 | Monsanto Company | Clarification of protein precipitate suspensions using anionic polymeric flocculants |
US6437101B1 (en) | 1999-05-07 | 2002-08-20 | Akzo Nobel N.V. | Methods for protein purification using aqueous two-phase extraction |
KR20090007504A (ko) | 2000-02-24 | 2009-01-16 | 몬산토 테크놀로지 엘엘씨 | 소마토트로핀의 지속적인 방출을 위한 비수성 주사제제들 |
AU2001271491A1 (en) | 2000-06-26 | 2002-01-08 | Monsanto Technology Llc | Non-aqueous surfactant-containing formulations for extended release of somatotropin |
US6664234B1 (en) * | 2000-06-30 | 2003-12-16 | Monsanto Technology Llc | Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin |
JP4886654B2 (ja) * | 2007-10-29 | 2012-02-29 | 日本ケミカルリサーチ株式会社 | ヒト成長ホルモンの効率化された製造方法 |
CN104017063A (zh) | 2009-12-21 | 2014-09-03 | Ambrx公司 | 经过修饰的猪促生长素多肽和其用途 |
EA201290541A1 (ru) | 2009-12-21 | 2013-05-30 | Амбркс, Инк. | Модифицированные бычьи соматотропиновые полипептиды и их применение |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4054557A (en) * | 1974-05-15 | 1977-10-18 | Ab Kabi | Growth promoting polypeptides and preparation method |
US4426323A (en) * | 1980-01-10 | 1984-01-17 | Ionics, Incorporated | Selected recovery of proteins from fermentation broths |
DE3119453A1 (de) * | 1981-05-15 | 1982-12-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zum reinigen bzw. anreichern von biologisch aktiven proteinen und hierzu geeignetes mittel |
US4745069A (en) * | 1982-05-25 | 1988-05-17 | Eli Lilly And Company | Cloning vectors for expression of exogenous protein |
US4534906A (en) * | 1982-11-01 | 1985-08-13 | Genentech, Inc. | Removal of impurities from human leukocyte interferon preparations |
US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4569794A (en) * | 1984-12-05 | 1986-02-11 | Eli Lilly And Company | Process for purifying proteins and compounds useful in such process |
US4652630A (en) * | 1985-02-22 | 1987-03-24 | Monsanto Company | Method of somatotropin naturation |
ES8800957A1 (es) * | 1985-02-22 | 1987-12-01 | Monsanto Co | Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina |
US4612367A (en) * | 1985-04-08 | 1986-09-16 | Eli Lilly And Company | Process for purifying growth hormone-like materials |
US4617376A (en) * | 1985-07-01 | 1986-10-14 | Eli Lilly And Company | Process for recovering glucagon from pancreas glands |
US4863736A (en) * | 1987-03-16 | 1989-09-05 | Monsanto Company | Somatotropin prolonged release |
JPH01257491A (ja) * | 1988-04-08 | 1989-10-13 | Tosoh Corp | 不溶性融合異種蛋白質の処理方法 |
US5182369A (en) * | 1990-02-28 | 1993-01-26 | Monsanto Company | Method for purifying somatotropin monomers |
-
1990
- 1990-02-28 US US07/486,476 patent/US5182369A/en not_active Expired - Lifetime
-
1991
- 1991-02-27 IE IE66191A patent/IE77159B1/en not_active IP Right Cessation
- 1991-02-27 AU AU71959/91A patent/AU633699B2/en not_active Expired
- 1991-02-27 CA CA002037244A patent/CA2037244C/en not_active Expired - Lifetime
- 1991-02-27 ZA ZA911448A patent/ZA911448B/xx unknown
- 1991-02-27 AT AT91870033T patent/ATE142227T1/de not_active IP Right Cessation
- 1991-02-27 DE DE69121742T patent/DE69121742D1/de not_active Expired - Lifetime
- 1991-02-27 IL IL9737691A patent/IL97376A/en not_active IP Right Cessation
- 1991-02-27 EP EP91870033A patent/EP0445099B1/de not_active Expired - Lifetime
- 1991-02-27 NZ NZ237240A patent/NZ237240A/en unknown
- 1991-02-28 JP JP3216708A patent/JP2798531B2/ja not_active Expired - Fee Related
-
1995
- 1995-12-21 US US08/576,517 patent/US5986073A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US5986073A (en) | 1999-11-16 |
CA2037244A1 (en) | 1991-08-29 |
NZ237240A (en) | 1992-05-26 |
IE910661A1 (en) | 1991-08-28 |
AU7195991A (en) | 1991-08-29 |
IL97376A (en) | 2001-03-19 |
JPH07303492A (ja) | 1995-11-21 |
IE77159B1 (en) | 1997-12-03 |
US5182369A (en) | 1993-01-26 |
IL97376A0 (en) | 1992-05-25 |
AU633699B2 (en) | 1993-02-04 |
EP0445099B1 (de) | 1996-09-04 |
CA2037244C (en) | 1998-09-22 |
ATE142227T1 (de) | 1996-09-15 |
EP0445099A1 (de) | 1991-09-04 |
JP2798531B2 (ja) | 1998-09-17 |
ZA911448B (en) | 1992-02-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |