ATE383368T1 - Verfahren zur rückgewinnung von beta-interferon - Google Patents

Verfahren zur rückgewinnung von beta-interferon

Info

Publication number
ATE383368T1
ATE383368T1 AT01985190T AT01985190T ATE383368T1 AT E383368 T1 ATE383368 T1 AT E383368T1 AT 01985190 T AT01985190 T AT 01985190T AT 01985190 T AT01985190 T AT 01985190T AT E383368 T1 ATE383368 T1 AT E383368T1
Authority
AT
Austria
Prior art keywords
ifn
renaturation
hcl
purification method
beta interferon
Prior art date
Application number
AT01985190T
Other languages
English (en)
Inventor
Sid Wolfe
Irina Esikova
Susan Babuka
Bret Shirley
Dennis Fordham
Original Assignee
Novartis Vaccines & Diagnostic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Vaccines & Diagnostic filed Critical Novartis Vaccines & Diagnostic
Application granted granted Critical
Publication of ATE383368T1 publication Critical patent/ATE383368T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AT01985190T 2000-10-27 2001-10-26 Verfahren zur rückgewinnung von beta-interferon ATE383368T1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US24396500P 2000-10-27 2000-10-27
US28260701P 2001-04-09 2001-04-09
US33037501P 2001-10-18 2001-10-18
US10/035,420 US7544354B2 (en) 2000-10-27 2001-10-25 Methods of protein purification and recovery

Publications (1)

Publication Number Publication Date
ATE383368T1 true ATE383368T1 (de) 2008-01-15

Family

ID=27488301

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01985190T ATE383368T1 (de) 2000-10-27 2001-10-26 Verfahren zur rückgewinnung von beta-interferon

Country Status (16)

Country Link
US (3) US7544354B2 (de)
EP (1) EP1366060B1 (de)
JP (1) JP3946139B2 (de)
CN (1) CN100493601C (de)
AT (1) ATE383368T1 (de)
AU (1) AU2002234161B2 (de)
BG (1) BG66119B1 (de)
CA (1) CA2427088C (de)
CZ (1) CZ301360B6 (de)
DE (1) DE60132366T2 (de)
ES (1) ES2299528T3 (de)
IL (1) IL155577A0 (de)
NO (1) NO326288B1 (de)
PL (1) PL206428B1 (de)
PT (1) PT1366060E (de)
WO (1) WO2002034791A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7544354B2 (en) * 2000-10-27 2009-06-09 Novartis Vaccines And Diagnostics Methods of protein purification and recovery
CN1245215C (zh) 2001-02-28 2006-03-15 四川省生物工程研究中心 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂
US20060035327A1 (en) * 2001-02-28 2006-02-16 Guangwen Wei Recombinant super-compound interferon and uses thereof
US20050079579A1 (en) * 2001-02-28 2005-04-14 Guangwen Wei Uses of spatial configuration to modulate protein function
US6887462B2 (en) 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta
US20050029194A1 (en) * 2003-08-07 2005-02-10 Hall David Bruce Method for removal of guanidine compound from aqueous media
US7585647B2 (en) * 2003-08-28 2009-09-08 Guangwen Wei Nucleic acid encoding recombinant interferon
US20080124302A1 (en) * 2005-03-09 2008-05-29 Guangwen Wei Uses of Recombinant Super-Compound Interferons
US7754861B2 (en) * 2005-03-23 2010-07-13 Bio-Rad Laboratories, Inc. Method for purifying proteins
US20090247421A1 (en) * 2005-03-23 2009-10-01 Egisto Boschetti Diverse chemical libraries bound to small particles with paramagnetic properties
US20070027305A1 (en) * 2005-07-29 2007-02-01 Novartis Ag Method and system for in vitro protein folding
WO2007020886A1 (ja) 2005-08-16 2007-02-22 Sanyo Chemical Industries, Ltd. タンパク質のリフォールディング剤およびリフォールディング方法
JP2007126391A (ja) * 2005-11-02 2007-05-24 Sanyo Chem Ind Ltd タンパク質のリフォールディング剤
JP4786303B2 (ja) * 2005-11-02 2011-10-05 三洋化成工業株式会社 タンパク質のリフォールディング剤
JP5274795B2 (ja) * 2006-07-27 2013-08-28 三洋化成工業株式会社 タンパク質のリフォールディング方法
CN103965347B (zh) 2007-05-02 2017-07-18 Ambrx公司 经修饰干扰素β多肽和其用途
US8273561B2 (en) * 2007-10-05 2012-09-25 Nuron Biotech, Inc. High pressure treatment of aggregated interferons
KR101113495B1 (ko) 2008-01-23 2012-02-29 한미홀딩스 주식회사 인간 인터페론 베타의 정제방법
GB0821010D0 (en) * 2008-11-17 2008-12-24 Univ Warwick Plant development control composition
CN101885767B (zh) * 2010-06-13 2013-03-13 深圳科兴生物工程有限公司 一种取代单克隆抗体亲和层析的分离纯化重组人干扰素α1b的方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992271A (en) * 1982-09-23 1991-02-12 Cetus Corporation Formulation for lipophilic IL-2 proteins
US4462940A (en) * 1982-09-23 1984-07-31 Cetus Corporation Process for the recovery of human β-interferon-like polypeptides
US5702699A (en) * 1982-09-23 1997-12-30 Cetus Corporation Process for the recovery of lipophilic proteins
US5643566A (en) * 1982-09-23 1997-07-01 Cetus Corporation Formulation processes for lipophilic proteins
US4816440A (en) 1985-09-26 1989-03-28 Cetus Corporation Stable formulation of biologically active proteins for parenteral injection
US5183746A (en) * 1986-10-27 1993-02-02 Schering Aktiengesellschaft Formulation processes for pharmaceutical compositions of recombinant β-
CA1294215C (en) 1986-10-27 1992-01-14 Ze'ev Shaked Pharmaceutical compositions of recombinant beta-interferon and formulation processes
US4894330A (en) * 1986-12-23 1990-01-16 Cetus Corporation Purification of recombinant beta-interferon incorporating RP-HPLC
US4931543A (en) * 1987-05-11 1990-06-05 Cetus Corporation Process for recovering microbially produced interleukin-2
US5162507A (en) * 1987-05-11 1992-11-10 Cetus Corporation Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms
US5004605A (en) * 1987-12-10 1991-04-02 Cetus Corporation Low pH pharmaceutical compositions of recombinant β-interferon
CA1340586C (en) 1988-09-23 1999-06-08 Cetus Corporation Process for recovering microbially produced interferon-beta
KR930006706B1 (ko) 1991-04-29 1993-07-23 주식회사 럭키 인간 인터페론 베타의 정제방법
DE4407325B4 (de) * 1994-03-04 2006-06-29 Basf Ag Verfahren zur Herstellung von 3-Aminomethyl-3,5,5-trimethylcyclohexylamin
CN1073119C (zh) 1994-05-18 2001-10-17 吸入治疗系统公司 干扰素干粉配方的方法及组合物
US5814485A (en) * 1995-06-06 1998-09-29 Chiron Corporation Production of interferon-β (IFN-β) in E. coli
BR9606270A (pt) 1996-12-18 1998-09-22 Univ Minas Gerais Processo para a produção da proteína do interferon beta-cis humano recombinante e proteína de interferon beta-cis humano recombinante
US20030190307A1 (en) * 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
US7544354B2 (en) * 2000-10-27 2009-06-09 Novartis Vaccines And Diagnostics Methods of protein purification and recovery
US6887462B2 (en) * 2001-04-09 2005-05-03 Chiron Corporation HSA-free formulations of interferon-beta

Also Published As

Publication number Publication date
CN1479627A (zh) 2004-03-03
CZ20031157A3 (en) 2004-03-17
US20090123424A1 (en) 2009-05-14
CZ301360B6 (cs) 2010-01-27
CA2427088A1 (en) 2002-05-02
EP1366060A2 (de) 2003-12-03
DE60132366T2 (de) 2009-01-29
US20020137895A1 (en) 2002-09-26
AU2002234161B2 (en) 2006-10-19
US20040115169A1 (en) 2004-06-17
CN100493601C (zh) 2009-06-03
PL365896A1 (en) 2005-01-10
PT1366060E (pt) 2008-03-17
US8388942B2 (en) 2013-03-05
NO20031839D0 (no) 2003-04-24
DE60132366D1 (de) 2008-02-21
WO2002034791A2 (en) 2002-05-02
JP3946139B2 (ja) 2007-07-18
BG66119B1 (bg) 2011-05-31
ES2299528T3 (es) 2008-06-01
US7544354B2 (en) 2009-06-09
BG107844A (bg) 2004-07-30
PL206428B1 (pl) 2010-08-31
JP2004512343A (ja) 2004-04-22
NO326288B1 (no) 2008-11-03
IL155577A0 (en) 2003-11-23
EP1366060B1 (de) 2008-01-09
NO20031839L (no) 2003-05-28
CA2427088C (en) 2011-06-21
WO2002034791A3 (en) 2003-10-09

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