ATE96805T1 - Verfahren zur rueckgewinnung rekombinanter proteine. - Google Patents
Verfahren zur rueckgewinnung rekombinanter proteine.Info
- Publication number
- ATE96805T1 ATE96805T1 AT90907861T AT90907861T ATE96805T1 AT E96805 T1 ATE96805 T1 AT E96805T1 AT 90907861 T AT90907861 T AT 90907861T AT 90907861 T AT90907861 T AT 90907861T AT E96805 T1 ATE96805 T1 AT E96805T1
- Authority
- AT
- Austria
- Prior art keywords
- protein
- molecular weight
- high molecular
- solution
- methods
- Prior art date
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title abstract 3
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 5
- 108090000623 proteins and genes Proteins 0.000 abstract 5
- 239000000356 contaminant Substances 0.000 abstract 2
- 239000002244 precipitate Substances 0.000 abstract 2
- 239000000243 solution Substances 0.000 abstract 2
- 150000001412 amines Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000012460 protein solution Substances 0.000 abstract 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/30—Extraction; Separation; Purification by precipitation
- C07K1/303—Extraction; Separation; Purification by precipitation by salting out
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/364,846 US5101018A (en) | 1989-06-12 | 1989-06-12 | Method for recovering recombinant proteins |
PCT/US1990/002652 WO1990015876A1 (en) | 1989-06-12 | 1990-05-10 | Method for recovering recombinant proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE96805T1 true ATE96805T1 (de) | 1993-11-15 |
Family
ID=23436347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT90907861T ATE96805T1 (de) | 1989-06-12 | 1990-05-10 | Verfahren zur rueckgewinnung rekombinanter proteine. |
Country Status (14)
Country | Link |
---|---|
US (1) | US5101018A (de) |
EP (1) | EP0477198B1 (de) |
JP (1) | JP2957695B2 (de) |
KR (1) | KR0178274B1 (de) |
AT (1) | ATE96805T1 (de) |
AU (1) | AU634547B2 (de) |
BR (1) | BR9007433A (de) |
CA (1) | CA2060505C (de) |
DE (1) | DE69004429T2 (de) |
DK (1) | DK0477198T3 (de) |
ES (1) | ES2046782T3 (de) |
HU (2) | HU209651B (de) |
RU (1) | RU2075509C1 (de) |
WO (1) | WO1990015876A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5047511A (en) * | 1989-08-28 | 1991-09-10 | Pitman-Moore, Inc. | Method for recovering recombinant proteins |
US5605691A (en) * | 1992-09-17 | 1997-02-25 | Ophidian Pharmaceuticals, Inc. | Immunologically active proteins from inclusion bodies |
US5869604A (en) * | 1995-11-09 | 1999-02-09 | Georgia Institute Of Technology | Crystallization and purification of polypeptides |
CA2498319A1 (en) * | 2002-09-09 | 2004-03-18 | Nautilus Biotech | Rational evolution of cytokines for higher stability, the cytokines and encoding nucleic acid molecules |
US7998930B2 (en) | 2004-11-04 | 2011-08-16 | Hanall Biopharma Co., Ltd. | Modified growth hormones |
MX2011007736A (es) * | 2009-01-22 | 2011-09-06 | Novo Nordisk Healthcare Ag | Compuestos de hormona del crecimiento estables. |
TWI508737B (zh) | 2010-01-22 | 2015-11-21 | 諾佛 儂迪克股份有限公司 | 具有延長的活體內功效的生長激素 |
JP5980689B2 (ja) | 2010-01-22 | 2016-08-31 | ノヴォ・ノルディスク・ヘルス・ケア・アーゲー | 安定な成長ホルモン化合物 |
US11045523B2 (en) | 2013-04-05 | 2021-06-29 | Novo Nordisk Healthcare Ag | Formulation of growth hormone albumin-binder conjugate |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2175090A (en) * | 1938-06-22 | 1939-10-03 | Lederie Lab Inc | Purification of antibody compositions |
US3657071A (en) * | 1968-11-12 | 1972-04-18 | Hans Ulrich Bergmeyer | Fractionation of proteins |
US3749668A (en) * | 1971-05-03 | 1973-07-31 | Rohm & Haas | Water purification with amine oxide resins |
DE2718325C2 (de) * | 1977-04-25 | 1986-09-25 | Behringwerke Ag, 3550 Marburg | Leucinreiches 3,1-S-α↓2↓-Glykoprotein sowie dessen Verwendung |
US4204989A (en) * | 1978-12-13 | 1980-05-27 | Merck & Co., Inc. | Isolation of hepatitis B e antigen |
DE2946458A1 (de) * | 1979-11-17 | 1981-06-11 | Behringwerke Ag, 3550 Marburg | Neues protein pp(pfeil abwaerts)11(pfeil abwaerts) |
US4778813A (en) * | 1981-07-07 | 1988-10-18 | Buckman Laboratories International, Inc. | Polymeric quaternary ammonium compounds, their preparation and use |
JPH0738880B2 (ja) * | 1983-06-24 | 1995-05-01 | 東レ株式会社 | エンドトキシン血症治療剤 |
US4634673A (en) * | 1984-03-28 | 1987-01-06 | Nabisco Brands, Inc. | Enzyme purification process |
DE3484713D1 (de) * | 1984-09-10 | 1991-07-18 | Toray Industries | Ionenaustausch- oder adsorptionsverfahren. |
SE462100B (sv) * | 1985-08-08 | 1990-05-07 | Perstorp Ab | Komposition och dess anvaendning i ett tvaa- eller flerfassystem |
US4677196A (en) * | 1985-09-06 | 1987-06-30 | International Minerals & Chemical Corp. | Purification and activation of proteins from insoluble inclusion bodies |
DE3608091A1 (de) * | 1986-03-12 | 1987-09-17 | Basf Ag | Verfahren zum isolieren und reinigen von haemin |
US4771128A (en) * | 1986-10-10 | 1988-09-13 | Cetus Corporation | Method of purifying toxin conjugates using hydrophobic interaction chromatography |
AU612133B2 (en) * | 1987-02-20 | 1991-07-04 | Natinco Nv | Production of proteins in active forms |
EP0295859B1 (de) * | 1987-06-15 | 1994-11-17 | Southern Cross Biotech Pty.Ltd. | Herstellung von Proteinen in aktiver Form |
-
1989
- 1989-06-12 US US07/364,846 patent/US5101018A/en not_active Expired - Lifetime
-
1990
- 1990-05-10 HU HU904388A patent/HU209651B/hu not_active IP Right Cessation
- 1990-05-10 RU SU905010961A patent/RU2075509C1/ru active
- 1990-05-10 EP EP90907861A patent/EP0477198B1/de not_active Expired - Lifetime
- 1990-05-10 AU AU56442/90A patent/AU634547B2/en not_active Ceased
- 1990-05-10 BR BR909007433A patent/BR9007433A/pt not_active Application Discontinuation
- 1990-05-10 KR KR1019910701832A patent/KR0178274B1/ko not_active IP Right Cessation
- 1990-05-10 DK DK90907861.0T patent/DK0477198T3/da active
- 1990-05-10 CA CA002060505A patent/CA2060505C/en not_active Expired - Fee Related
- 1990-05-10 JP JP2507613A patent/JP2957695B2/ja not_active Expired - Fee Related
- 1990-05-10 DE DE90907861T patent/DE69004429T2/de not_active Expired - Fee Related
- 1990-05-10 HU HU8843Q patent/HUT61053A/hu unknown
- 1990-05-10 ES ES199090907861T patent/ES2046782T3/es not_active Expired - Lifetime
- 1990-05-10 AT AT90907861T patent/ATE96805T1/de not_active IP Right Cessation
- 1990-05-10 WO PCT/US1990/002652 patent/WO1990015876A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
DK0477198T3 (da) | 1993-11-29 |
EP0477198B1 (de) | 1993-11-03 |
HU209651B (en) | 1994-09-28 |
HUT61053A (en) | 1992-11-30 |
AU634547B2 (en) | 1993-02-25 |
WO1990015876A1 (en) | 1990-12-27 |
RU2075509C1 (ru) | 1997-03-20 |
KR0178274B1 (ko) | 1999-04-01 |
ES2046782T3 (es) | 1994-02-01 |
US5101018A (en) | 1992-03-31 |
JP2957695B2 (ja) | 1999-10-06 |
CA2060505C (en) | 2001-06-12 |
CA2060505A1 (en) | 1990-12-13 |
DE69004429D1 (de) | 1993-12-09 |
DE69004429T2 (de) | 1994-03-31 |
BR9007433A (pt) | 1992-06-16 |
AU5644290A (en) | 1991-01-08 |
EP0477198A1 (de) | 1992-04-01 |
HU904388D0 (en) | 1992-04-28 |
JPH04505706A (ja) | 1992-10-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |