ATE161013T1 - Verfahren zum reinigen von 20 cs)-camptothecin - Google Patents

Verfahren zum reinigen von 20 cs)-camptothecin

Info

Publication number
ATE161013T1
ATE161013T1 AT94909723T AT94909723T ATE161013T1 AT E161013 T1 ATE161013 T1 AT E161013T1 AT 94909723 T AT94909723 T AT 94909723T AT 94909723 T AT94909723 T AT 94909723T AT E161013 T1 ATE161013 T1 AT E161013T1
Authority
AT
Austria
Prior art keywords
camptothecin
purifying
cancer
useful
treatment
Prior art date
Application number
AT94909723T
Other languages
English (en)
Inventor
Hellmuth R Hinz
Original Assignee
Stehlin Foundation For Cancer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/022,091 external-priority patent/US5352789A/en
Application filed by Stehlin Foundation For Cancer filed Critical Stehlin Foundation For Cancer
Application granted granted Critical
Publication of ATE161013T1 publication Critical patent/ATE161013T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
AT94909723T 1993-02-25 1994-02-24 Verfahren zum reinigen von 20 cs)-camptothecin ATE161013T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/022,091 US5352789A (en) 1993-02-25 1993-02-25 Methods for purifying camptothecin compounds
US08/200,398 US5527913A (en) 1993-02-25 1994-02-23 Methods for purifying camptothecin compounds

Publications (1)

Publication Number Publication Date
ATE161013T1 true ATE161013T1 (de) 1997-12-15

Family

ID=26695501

Family Applications (1)

Application Number Title Priority Date Filing Date
AT94909723T ATE161013T1 (de) 1993-02-25 1994-02-24 Verfahren zum reinigen von 20 cs)-camptothecin

Country Status (5)

Country Link
US (4) US5527913A (de)
EP (1) EP0686158B1 (de)
AT (1) ATE161013T1 (de)
DE (1) DE69407272D1 (de)
WO (1) WO1994019353A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5527913A (en) * 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5731316A (en) * 1996-01-30 1998-03-24 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6407118B1 (en) 1996-01-30 2002-06-18 The Stehlin Foundation For Cancer Research Derivatives of camptothecin and methods of treating cancer using these derivatives
US5922877A (en) * 1997-08-05 1999-07-13 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
USRE38408E1 (en) 1997-08-05 2004-01-27 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin
US6352996B1 (en) 1999-08-03 2002-03-05 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6228855B1 (en) 1999-08-03 2001-05-08 The Stehlin Foundation For Cancer Research Aromatic esters of camptothecins and methods to treat cancers
EP2266607A3 (de) 1999-10-01 2011-04-20 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
CA2427467C (en) 2000-11-09 2010-01-12 Neopharm, Inc. Sn-38 lipid complexes and methods of use
DE10106969C1 (de) * 2001-02-15 2002-10-02 Boehringer Ingelheim Pharma Verfahren zur Reinigung und zur Herstellung von 20(S)-Camptothecin
US6476225B2 (en) * 2001-02-15 2002-11-05 Boehringer Ingelheim Pharma Kg Process for purifying 20(S)-camptothecin
WO2003030864A1 (en) * 2001-05-29 2003-04-17 Neopharm, Inc. Liposomal formulation of irinotecan
MXPA04008213A (es) * 2002-02-28 2005-05-16 Mallinckrodt Inc Metodo y sistema para la separacion y purificacion de por lo menos un alcaloide narcotico usando cromatografia preparativa de fase inversa.
AU2003296897A1 (en) * 2002-08-20 2004-05-04 Neopharm, Inc. Pharmaceutical formulations of camptothecine derivatives
US20060030578A1 (en) * 2002-08-20 2006-02-09 Neopharm, Inc. Pharmaceutically active lipid based formulation of irinotecan
US6893668B2 (en) * 2003-03-31 2005-05-17 Council Of Scientific And Industrial Research Process for isolation of anticancer agent camptothecin from Nothapodytes foetida
AU2004254011C1 (en) * 2003-06-27 2008-04-24 Unilever Plc Process for interesterification of a glyceride fat
JP4433918B2 (ja) * 2004-07-15 2010-03-17 コニカミノルタエムジー株式会社 画像形成方法
KR100651728B1 (ko) * 2004-11-10 2006-12-06 한국전자통신연구원 정착기를 갖는 전자 소자용 화합물 및 이를 포함하는 전자소자와 이들의 제조 방법
US20060135546A1 (en) * 2004-12-16 2006-06-22 Jagadevappa Basavaraja Methods for the purification of 20(S)- camptothecin
KR20090036585A (ko) * 2006-08-11 2009-04-14 더 크리스터스 스텔린 파운데이션 포 캔서 리서치 캄프토테신의 에스테르의 제조 방법
US7572803B2 (en) * 2007-10-25 2009-08-11 The Christus Stehlin Foundation For Cancer Research Hydrated crystalline esters of camptothecin

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3894029A (en) * 1971-08-26 1975-07-08 Basf Ag Production of camptothecin and camptothecin-like compounds
US4399282A (en) * 1979-07-10 1983-08-16 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives
JPS56108787A (en) * 1980-01-31 1981-08-28 Sato Yakugaku Kenkyusho:Kk Camptothecin coline salt and its preparation
US4473692A (en) * 1981-09-04 1984-09-25 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
US5053512A (en) * 1987-04-14 1991-10-01 Research Triangle Institute Total synthesis of 20(S) and 20(R)-camptothecin and compthothecin derivatives
US5180722A (en) * 1987-04-14 1993-01-19 Research Triangle Institute 10,11-methylenedioxy-20(RS)-camptothecin and 10,11-methylenedioxy-20(S)-camptothecin analogs
CA1332413C (en) * 1987-06-25 1994-10-11 Kabushiki Kaisha Yakult Honsha Camptothecin derivatives and process for preparing same
JPS6461482A (en) * 1987-08-31 1989-03-08 Yakult Honsha Kk Dehydrocamptothecin and production thereof
US4943579A (en) * 1987-10-06 1990-07-24 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Water soluble prodrugs of camptothecin
HUT70024A (en) * 1990-09-28 1995-09-28 Smithkline Beecham Corp Process for preparing water soluble camptothecin analogs
US5352789A (en) * 1993-02-25 1994-10-04 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
US5527913A (en) * 1993-02-25 1996-06-18 The Stehlin Foundation For Cancer Research Methods for purifying camptothecin compounds
IT1269862B (it) * 1994-05-30 1997-04-15 Indena Spa Alcaloidi da mappia foetida, loro uso e formulazioni che li contengono
US5922877A (en) * 1997-08-05 1999-07-13 The Stehlin Foundation For Cancer Research Methods of preparing and purifying 9-nitro-20-camptothecin

Also Published As

Publication number Publication date
WO1994019353A1 (en) 1994-09-01
EP0686158B1 (de) 1997-12-10
DE69407272D1 (de) 1998-01-22
US6156897A (en) 2000-12-05
EP0686158A1 (de) 1995-12-13
US5608066A (en) 1997-03-04
US6107486A (en) 2000-08-22
US5527913A (en) 1996-06-18

Similar Documents

Publication Publication Date Title
ATE161013T1 (de) Verfahren zum reinigen von 20 cs)-camptothecin
DE68922427T2 (de) Verfahren zur Zurückgewinnung von sauerstoffreichem Gas.
DE69329461T2 (de) Verfahren zur extraktion und reinigung von hamoglobin
DE3856398T2 (de) Verfahren zur Behandlung von Gleitkörpern
DE68926732T2 (de) Verfahren zur Reinigung von gasförmigem Stickstofftrifluorid
DE3888205D1 (de) Verfahren zur behandlung von lungenaffektionen und zubereitungen dafür.
DE69116623T2 (de) Verfahren zur Reinigung von 1,1,1,2-Tetrafluorethan
DE68900949D1 (de) Verfahren zur trennung von wasserstoffbehandlungs-ausfluessen.
DE69214610D1 (de) Verfahren zur Behandlung von Erdgas
DE68905379T2 (de) Verfahren zur Reinigung von Stickstofftrifluoridgas.
ATE206158T1 (de) Verfahren zur herstellung von gereinigtem enzym
DE69423131D1 (de) Verfahren zur Behandlung von Mycobakterien enthaltenden Auswürfen
DE69305411T2 (de) Verfahren zur Beseitigung von Mikroorganismen
DE3873094T2 (de) Verfahren zur aufbereitung von gas.
DE69205526D1 (de) Verfahren zur Rückgewinnung von C2+ und C3+ Kohlenwasserstoffen.
DE59209268D1 (de) Verfahren zur thermochemisch-thermischen behandlung von einsatzstählen
DE69309843D1 (de) Verfahren zur Wiedergewinnung von Bortrifluorid
DE69320906D1 (de) Mikroorganismen und Verfahren zur biologischen Entfernung von Nitratderivaten
DE69304638D1 (de) Verfahren zur Reinigung von 1,1,1,2-Tetrafluorethan
DE69103021D1 (de) Verfahren zur verminderung des reissens von laufendem garn.
DE69301353T2 (de) Verfahren zur Wiedergewinnung von Thiocyanat
DE69006489D1 (de) Verfahren zur kontinuierlichen wiedergewinnung von fluorwasserstoffgas.
DE59404368D1 (de) Verfahren zur herstellung von pentafluorethan und zur reinigung von 1,1,1,2-tetrafluorethan
DE59107748D1 (de) Verfahren zur Reinigung von fermentativ hergestelltem Riboflavin
DE69301936D1 (de) Verfahren zur Behandlung von Rauchgas

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties