DE3782986D1 - Verfahren zur trennung von n-geschuetzten alpha-l-aspartyl-l-phenylalaninen. - Google Patents

Verfahren zur trennung von n-geschuetzten alpha-l-aspartyl-l-phenylalaninen.

Info

Publication number
DE3782986D1
DE3782986D1 DE8787307027T DE3782986T DE3782986D1 DE 3782986 D1 DE3782986 D1 DE 3782986D1 DE 8787307027 T DE8787307027 T DE 8787307027T DE 3782986 T DE3782986 T DE 3782986T DE 3782986 D1 DE3782986 D1 DE 3782986D1
Authority
DE
Germany
Prior art keywords
phenylalanines
aspartyl
separating
protected alpha
alpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8787307027T
Other languages
English (en)
Other versions
DE3782986T2 (de
Inventor
Toyoto Central Research Hijiya
Tadashi Tokai Plant Takemoto
Toshihide Central Resea Yukaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ajinomoto Co Inc
Original Assignee
Ajinomoto Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ajinomoto Co Inc filed Critical Ajinomoto Co Inc
Application granted granted Critical
Publication of DE3782986D1 publication Critical patent/DE3782986D1/de
Publication of DE3782986T2 publication Critical patent/DE3782986T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
    • C07K5/0613—Aspartame
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/801—Peptide sweetners

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
DE8787307027T 1986-08-11 1987-08-07 Verfahren zur trennung von n-geschuetzten alpha-l-aspartyl-l-phenylalaninen. Expired - Fee Related DE3782986T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP61188341A JPS6344594A (ja) 1986-08-11 1986-08-11 Ｎ−保護−α−Ｌ−アスパルチル−Ｌ−フエニルアラニンの分離方法

Publications (2)

Publication Number Publication Date
DE3782986D1 true DE3782986D1 (de) 1993-01-21
DE3782986T2 DE3782986T2 (de) 1993-04-08

Family

ID=16221920

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787307027T Expired - Fee Related DE3782986T2 (de) 1986-08-11 1987-08-07 Verfahren zur trennung von n-geschuetzten alpha-l-aspartyl-l-phenylalaninen.

Country Status (6)

Country Link
US (1) US4803300A (de)
EP (1) EP0256812B1 (de)
JP (1) JPS6344594A (de)
KR (1) KR900006572B1 (de)
CA (1) CA1298432C (de)
DE (1) DE3782986T2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5283357A (en) * 1988-03-14 1994-02-01 Mitsui Toatsu Chemicals, Incorporated Separation method of α-l-aspartyl-l-phenylalanine methyl ester
JP3178092B2 (ja) * 1992-06-29 2001-06-18 味の素株式会社 α−Ｌ−アスパルチル−Ｌ−フェニルアラニンメチルエステル塩酸塩の製造方法
ES2068763B1 (es) * 1993-07-23 1995-10-01 Univ Madrid Complutense Procedimiento de purificacion del dipeptido *-l-aspartil-l-fenilalanina o de sus esteres alquilicos de bajo peso molecular.
JP3314515B2 (ja) * 1994-03-24 2002-08-12 味の素株式会社 Ｌ−フェニルアラニンの回収方法
JPH07278076A (ja) * 1994-04-12 1995-10-24 Ajinomoto Co Inc Ｌ−フェニルアラニン・モノメチル硫酸塩の晶析方法
US6657073B1 (en) 1999-08-18 2003-12-02 Daesang Corporation Crystallization of α-L-aspartyl-L-phenylalanine methyl ester

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3786039A (en) * 1969-04-30 1974-01-15 Ajinomoto Kk Method of producing alpha-l-aspartyl-l-phenylalanine lower alkyl esters
US3933781A (en) * 1973-11-05 1976-01-20 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine alkyl esters
US4173562A (en) * 1976-12-27 1979-11-06 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester
JPS5526133A (en) * 1978-08-11 1980-02-25 Hitachi Ltd Gripper for tension reel drum
US4480112A (en) * 1983-06-20 1984-10-30 G. D. Searle & Co. Method and intermediates for producing α-L-aspartyl-L-phenylalanine
IT1175926B (it) * 1984-01-13 1987-08-12 Debi Derivati Biologici Procedimento per la preparazione dell'estere metilico di alfa-l-aspartil-l-fenilalanina
JPH07636B2 (ja) * 1984-12-17 1995-01-11 三井東圧化学株式会社 Ｎ−ホルミル−α−アスパルチルフエニルアラニンの製造法
US4680403A (en) * 1985-01-17 1987-07-14 Ajinomoto Co., Inc. Process for producing N-protected-α-L-aspartyl-L-phenylalanine methyl ester
US4677220A (en) * 1985-10-31 1987-06-30 Monsanto Company Process for the preparation of α-L-aspartyl-L-phenylalanine methyl ester

Also Published As

Publication number Publication date
KR900006572B1 (ko) 1990-09-13
EP0256812A3 (en) 1989-04-26
EP0256812B1 (de) 1992-12-09
US4803300A (en) 1989-02-07
DE3782986T2 (de) 1993-04-08
CA1298432C (en) 1992-03-31
JPS6344594A (ja) 1988-02-25
EP0256812A2 (de) 1988-02-24
KR880002895A (ko) 1988-05-12

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee