NO326288B1 - Fremgangsmate for fremstilling av en sammensetning omfattende monomer interferon-β - Google Patents
Fremgangsmate for fremstilling av en sammensetning omfattende monomer interferon-β Download PDFInfo
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- NO326288B1 NO326288B1 NO20031839A NO20031839A NO326288B1 NO 326288 B1 NO326288 B1 NO 326288B1 NO 20031839 A NO20031839 A NO 20031839A NO 20031839 A NO20031839 A NO 20031839A NO 326288 B1 NO326288 B1 NO 326288B1
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- ifn
- solution
- guanidine
- amino acid
- buffer
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- 210000004962 mammalian cell Anatomy 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 201000001441 melanoma Diseases 0.000 description 1
- 239000003226 mitogen Substances 0.000 description 1
- 201000006417 multiple sclerosis Diseases 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 230000010399 physical interaction Effects 0.000 description 1
- 108091033319 polynucleotide Proteins 0.000 description 1
- 102000040430 polynucleotide Human genes 0.000 description 1
- 239000002157 polynucleotide Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 230000001376 precipitating effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000004952 protein activity Effects 0.000 description 1
- 230000004853 protein function Effects 0.000 description 1
- 238000004064 recycling Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 230000004043 responsiveness Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 238000004513 sizing Methods 0.000 description 1
- 238000011172 small scale experimental method Methods 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000012289 standard assay Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
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- 239000003440 toxic substance Substances 0.000 description 1
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- 230000009385 viral infection Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/555—Interferons [IFN]
- C07K14/565—IFN-beta
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24396500P | 2000-10-27 | 2000-10-27 | |
| US28260701P | 2001-04-09 | 2001-04-09 | |
| US33037501P | 2001-10-18 | 2001-10-18 | |
| US10/035,420 US7544354B2 (en) | 2000-10-27 | 2001-10-25 | Methods of protein purification and recovery |
| PCT/US2001/051038 WO2002034791A2 (en) | 2000-10-27 | 2001-10-26 | Methods of purification and recovery of interferon-beta |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20031839D0 NO20031839D0 (no) | 2003-04-24 |
| NO20031839L NO20031839L (no) | 2003-05-28 |
| NO326288B1 true NO326288B1 (no) | 2008-11-03 |
Family
ID=27488301
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20031839A NO326288B1 (no) | 2000-10-27 | 2003-04-24 | Fremgangsmate for fremstilling av en sammensetning omfattende monomer interferon-β |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7544354B2 (de) |
| EP (1) | EP1366060B1 (de) |
| JP (1) | JP3946139B2 (de) |
| CN (1) | CN100493601C (de) |
| AT (1) | ATE383368T1 (de) |
| AU (1) | AU2002234161B2 (de) |
| BG (1) | BG66119B1 (de) |
| CA (1) | CA2427088C (de) |
| CZ (1) | CZ301360B6 (de) |
| DE (1) | DE60132366T2 (de) |
| ES (1) | ES2299528T3 (de) |
| IL (1) | IL155577A0 (de) |
| NO (1) | NO326288B1 (de) |
| PL (1) | PL206428B1 (de) |
| PT (1) | PT1366060E (de) |
| WO (1) | WO2002034791A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7544354B2 (en) * | 2000-10-27 | 2009-06-09 | Novartis Vaccines And Diagnostics | Methods of protein purification and recovery |
| US20050079579A1 (en) * | 2001-02-28 | 2005-04-14 | Guangwen Wei | Uses of spatial configuration to modulate protein function |
| CN1245215C (zh) * | 2001-02-28 | 2006-03-15 | 四川省生物工程研究中心 | 重组高效复合干扰素用作乙型肝炎表面抗原和e抗原抑制剂 |
| US20060035327A1 (en) * | 2001-02-28 | 2006-02-16 | Guangwen Wei | Recombinant super-compound interferon and uses thereof |
| US6887462B2 (en) | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
| US20050029194A1 (en) * | 2003-08-07 | 2005-02-10 | Hall David Bruce | Method for removal of guanidine compound from aqueous media |
| US7585647B2 (en) * | 2003-08-28 | 2009-09-08 | Guangwen Wei | Nucleic acid encoding recombinant interferon |
| JP5209462B2 (ja) * | 2005-03-09 | 2013-06-12 | ウェイ グアンウェン | コンセンサスインターフェロンの使用方法 |
| US7754861B2 (en) * | 2005-03-23 | 2010-07-13 | Bio-Rad Laboratories, Inc. | Method for purifying proteins |
| US20090247421A1 (en) * | 2005-03-23 | 2009-10-01 | Egisto Boschetti | Diverse chemical libraries bound to small particles with paramagnetic properties |
| AU2006275800A1 (en) * | 2005-07-29 | 2007-02-08 | Novartis Ag | Method and system for in vitro protein folding |
| WO2007020886A1 (ja) | 2005-08-16 | 2007-02-22 | Sanyo Chemical Industries, Ltd. | タンパク質のリフォールディング剤およびリフォールディング方法 |
| JP2007126391A (ja) * | 2005-11-02 | 2007-05-24 | Sanyo Chem Ind Ltd | タンパク質のリフォールディング剤 |
| JP4786303B2 (ja) * | 2005-11-02 | 2011-10-05 | 三洋化成工業株式会社 | タンパク質のリフォールディング剤 |
| JP5274795B2 (ja) * | 2006-07-27 | 2013-08-28 | 三洋化成工業株式会社 | タンパク質のリフォールディング方法 |
| WO2008137471A2 (en) | 2007-05-02 | 2008-11-13 | Ambrx, Inc. | Modified interferon beta polypeptides and their uses |
| WO2009045553A1 (en) * | 2007-10-05 | 2009-04-09 | Barofold, Inc. | High pressure treatment of aggregated interferons |
| KR101113495B1 (ko) | 2008-01-23 | 2012-02-29 | 한미홀딩스 주식회사 | 인간 인터페론 베타의 정제방법 |
| GB0821010D0 (en) * | 2008-11-17 | 2008-12-24 | Univ Warwick | Plant development control composition |
| CN101885767B (zh) * | 2010-06-13 | 2013-03-13 | 深圳科兴生物工程有限公司 | 一种取代单克隆抗体亲和层析的分离纯化重组人干扰素α1b的方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5702699A (en) * | 1982-09-23 | 1997-12-30 | Cetus Corporation | Process for the recovery of lipophilic proteins |
| US4462940A (en) * | 1982-09-23 | 1984-07-31 | Cetus Corporation | Process for the recovery of human β-interferon-like polypeptides |
| US5643566A (en) * | 1982-09-23 | 1997-07-01 | Cetus Corporation | Formulation processes for lipophilic proteins |
| US4992271A (en) * | 1982-09-23 | 1991-02-12 | Cetus Corporation | Formulation for lipophilic IL-2 proteins |
| US4816440A (en) | 1985-09-26 | 1989-03-28 | Cetus Corporation | Stable formulation of biologically active proteins for parenteral injection |
| US5183746A (en) * | 1986-10-27 | 1993-02-02 | Schering Aktiengesellschaft | Formulation processes for pharmaceutical compositions of recombinant β- |
| CA1294215C (en) | 1986-10-27 | 1992-01-14 | Ze'ev Shaked | Pharmaceutical compositions of recombinant beta-interferon and formulation processes |
| US4894330A (en) * | 1986-12-23 | 1990-01-16 | Cetus Corporation | Purification of recombinant beta-interferon incorporating RP-HPLC |
| US5162507A (en) * | 1987-05-11 | 1992-11-10 | Cetus Corporation | Process for recovering purified, oxidized, renatured recombinant interleukin-2 from microorganisms |
| US4931543A (en) * | 1987-05-11 | 1990-06-05 | Cetus Corporation | Process for recovering microbially produced interleukin-2 |
| US5004605A (en) * | 1987-12-10 | 1991-04-02 | Cetus Corporation | Low pH pharmaceutical compositions of recombinant β-interferon |
| CA1340586C (en) | 1988-09-23 | 1999-06-08 | Cetus Corporation | Process for recovering microbially produced interferon-beta |
| KR930006706B1 (ko) | 1991-04-29 | 1993-07-23 | 주식회사 럭키 | 인간 인터페론 베타의 정제방법 |
| DE4407325B4 (de) * | 1994-03-04 | 2006-06-29 | Basf Ag | Verfahren zur Herstellung von 3-Aminomethyl-3,5,5-trimethylcyclohexylamin |
| CA2190502A1 (en) | 1994-05-18 | 1995-11-23 | Robert M. Platz | Methods and compositions for the dry powder formulation of interferons |
| US5814485A (en) * | 1995-06-06 | 1998-09-29 | Chiron Corporation | Production of interferon-β (IFN-β) in E. coli |
| BR9606270A (pt) | 1996-12-18 | 1998-09-22 | Univ Minas Gerais | Processo para a produção da proteína do interferon beta-cis humano recombinante e proteína de interferon beta-cis humano recombinante |
| US20030190307A1 (en) * | 1996-12-24 | 2003-10-09 | Biogen, Inc. | Stable liquid interferon formulations |
| US7544354B2 (en) * | 2000-10-27 | 2009-06-09 | Novartis Vaccines And Diagnostics | Methods of protein purification and recovery |
| US6887462B2 (en) * | 2001-04-09 | 2005-05-03 | Chiron Corporation | HSA-free formulations of interferon-beta |
-
2001
- 2001-10-25 US US10/035,420 patent/US7544354B2/en not_active Expired - Lifetime
- 2001-10-26 DE DE60132366T patent/DE60132366T2/de not_active Expired - Lifetime
- 2001-10-26 CA CA2427088A patent/CA2427088C/en not_active Expired - Lifetime
- 2001-10-26 IL IL15557701A patent/IL155577A0/xx active IP Right Grant
- 2001-10-26 WO PCT/US2001/051038 patent/WO2002034791A2/en active IP Right Grant
- 2001-10-26 CZ CZ20031157A patent/CZ301360B6/cs not_active IP Right Cessation
- 2001-10-26 ES ES01985190T patent/ES2299528T3/es not_active Expired - Lifetime
- 2001-10-26 JP JP2002537777A patent/JP3946139B2/ja not_active Expired - Lifetime
- 2001-10-26 EP EP01985190A patent/EP1366060B1/de not_active Expired - Lifetime
- 2001-10-26 AT AT01985190T patent/ATE383368T1/de active
- 2001-10-26 AU AU2002234161A patent/AU2002234161B2/en not_active Expired
- 2001-10-26 PT PT01985190T patent/PT1366060E/pt unknown
- 2001-10-26 PL PL365896A patent/PL206428B1/pl unknown
- 2001-10-26 CN CNB018199836A patent/CN100493601C/zh not_active Expired - Lifetime
-
2003
- 2003-04-24 NO NO20031839A patent/NO326288B1/no not_active IP Right Cessation
- 2003-05-23 BG BG107844A patent/BG66119B1/bg unknown
- 2003-12-31 US US10/750,076 patent/US20040115169A1/en not_active Abandoned
-
2008
- 2008-04-29 US US12/150,530 patent/US8388942B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002034791A2 (en) | 2002-05-02 |
| BG107844A (bg) | 2004-07-30 |
| DE60132366D1 (de) | 2008-02-21 |
| PT1366060E (pt) | 2008-03-17 |
| US8388942B2 (en) | 2013-03-05 |
| US20020137895A1 (en) | 2002-09-26 |
| JP3946139B2 (ja) | 2007-07-18 |
| CZ20031157A3 (en) | 2004-03-17 |
| AU2002234161B2 (en) | 2006-10-19 |
| US20090123424A1 (en) | 2009-05-14 |
| BG66119B1 (bg) | 2011-05-31 |
| NO20031839L (no) | 2003-05-28 |
| CA2427088A1 (en) | 2002-05-02 |
| CN1479627A (zh) | 2004-03-03 |
| ATE383368T1 (de) | 2008-01-15 |
| DE60132366T2 (de) | 2009-01-29 |
| ES2299528T3 (es) | 2008-06-01 |
| PL206428B1 (pl) | 2010-08-31 |
| CA2427088C (en) | 2011-06-21 |
| EP1366060A2 (de) | 2003-12-03 |
| PL365896A1 (en) | 2005-01-10 |
| US20040115169A1 (en) | 2004-06-17 |
| CZ301360B6 (cs) | 2010-01-27 |
| JP2004512343A (ja) | 2004-04-22 |
| US7544354B2 (en) | 2009-06-09 |
| IL155577A0 (en) | 2003-11-23 |
| CN100493601C (zh) | 2009-06-03 |
| EP1366060B1 (de) | 2008-01-09 |
| WO2002034791A3 (en) | 2003-10-09 |
| NO20031839D0 (no) | 2003-04-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MK1K | Patent expired |