ATE142227T1 - Verfahren zur herstellung von somatotropinmonomeren in reiner form - Google Patents

Verfahren zur herstellung von somatotropinmonomeren in reiner form

Info

Publication number
ATE142227T1
ATE142227T1 AT91870033T AT91870033T ATE142227T1 AT E142227 T1 ATE142227 T1 AT E142227T1 AT 91870033 T AT91870033 T AT 91870033T AT 91870033 T AT91870033 T AT 91870033T AT E142227 T1 ATE142227 T1 AT E142227T1
Authority
AT
Austria
Prior art keywords
somatotropin
somatotropin monomers
monomers
solution
pure form
Prior art date
Application number
AT91870033T
Other languages
English (en)
Inventor
Stephen Bradly Storrs
Jeffrey Scott Schorey
Original Assignee
Monsanto Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
Application granted granted Critical
Publication of ATE142227T1 publication Critical patent/ATE142227T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormones [GH] (Somatotropin)
AT91870033T 1990-02-28 1991-02-27 Verfahren zur herstellung von somatotropinmonomeren in reiner form ATE142227T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/486,476 US5182369A (en) 1990-02-28 1990-02-28 Method for purifying somatotropin monomers

Publications (1)

Publication Number Publication Date
ATE142227T1 true ATE142227T1 (de) 1996-09-15

Family

ID=23932038

Family Applications (1)

Application Number Title Priority Date Filing Date
AT91870033T ATE142227T1 (de) 1990-02-28 1991-02-27 Verfahren zur herstellung von somatotropinmonomeren in reiner form

Country Status (11)

Country Link
US (2) US5182369A (de)
EP (1) EP0445099B1 (de)
JP (1) JP2798531B2 (de)
AT (1) ATE142227T1 (de)
AU (1) AU633699B2 (de)
CA (1) CA2037244C (de)
DE (1) DE69121742D1 (de)
IE (1) IE77159B1 (de)
IL (1) IL97376A (de)
NZ (1) NZ237240A (de)
ZA (1) ZA911448B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5182369A (en) * 1990-02-28 1993-01-26 Monsanto Company Method for purifying somatotropin monomers
WO1995008571A1 (en) * 1993-09-22 1995-03-30 American Cyanamid Company Porcine somatotropin having enhanced stability; process for producing
AU2592395A (en) * 1994-05-19 1995-12-18 Monsanto Company Method for purifying somatotropin monomers
ZA9711733B (en) 1996-12-31 1998-07-01 Monsanto Co Method for solubilization and naturation of somatotropins
DE69920711D1 (de) 1998-07-21 2004-11-04 Monsanto Technology Llc Klärung von protein-niederschlagsuspensionen durch verwendung von anionischen polymerischen flockungsmitteln
US6437101B1 (en) 1999-05-07 2002-08-20 Akzo Nobel N.V. Methods for protein purification using aqueous two-phase extraction
KR20080011353A (ko) 2000-02-24 2008-02-01 몬산토 테크놀로지 엘엘씨 소마토트로핀의 지속적인 방출을 위한 비수성 주사제제들
US6719992B2 (en) * 2000-06-26 2004-04-13 Monsanto Technology Llc Non-aqueous surfactant-containing formulations for extended release of somatotropin
US6664234B1 (en) * 2000-06-30 2003-12-16 Monsanto Technology Llc Non-aqueous injectable formulation preparation with pH adjusted for extended release of somatotropin
JP4886654B2 (ja) * 2007-10-29 2012-02-29 日本ケミカルリサーチ株式会社 ヒト成長ホルモンの効率化された製造方法
CN104017063A (zh) 2009-12-21 2014-09-03 Ambrx公司 经过修饰的猪促生长素多肽和其用途
CN107674121A (zh) 2009-12-21 2018-02-09 Ambrx 公司 经过修饰的牛促生长素多肽和其用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4054557A (en) * 1974-05-15 1977-10-18 Ab Kabi Growth promoting polypeptides and preparation method
US4426323A (en) * 1980-01-10 1984-01-17 Ionics, Incorporated Selected recovery of proteins from fermentation broths
DE3119453A1 (de) * 1981-05-15 1982-12-09 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zum reinigen bzw. anreichern von biologisch aktiven proteinen und hierzu geeignetes mittel
US4745069A (en) * 1982-05-25 1988-05-17 Eli Lilly And Company Cloning vectors for expression of exogenous protein
US4534906A (en) * 1982-11-01 1985-08-13 Genentech, Inc. Removal of impurities from human leukocyte interferon preparations
US4511502A (en) * 1982-12-22 1985-04-16 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
US4569794A (en) * 1984-12-05 1986-02-11 Eli Lilly And Company Process for purifying proteins and compounds useful in such process
US4652630A (en) * 1985-02-22 1987-03-24 Monsanto Company Method of somatotropin naturation
ES8800957A1 (es) * 1985-02-22 1987-12-01 Monsanto Co Un metodo para la solubilizacion y renaturalizacion de proteina somatotropina
US4612367A (en) * 1985-04-08 1986-09-16 Eli Lilly And Company Process for purifying growth hormone-like materials
US4617376A (en) * 1985-07-01 1986-10-14 Eli Lilly And Company Process for recovering glucagon from pancreas glands
US4863736A (en) * 1987-03-16 1989-09-05 Monsanto Company Somatotropin prolonged release
JPH01257491A (ja) * 1988-04-08 1989-10-13 Tosoh Corp 不溶性融合異種蛋白質の処理方法
US5182369A (en) * 1990-02-28 1993-01-26 Monsanto Company Method for purifying somatotropin monomers

Also Published As

Publication number Publication date
IL97376A0 (en) 1992-05-25
AU633699B2 (en) 1993-02-04
IL97376A (en) 2001-03-19
EP0445099B1 (de) 1996-09-04
AU7195991A (en) 1991-08-29
US5182369A (en) 1993-01-26
CA2037244C (en) 1998-09-22
NZ237240A (en) 1992-05-26
CA2037244A1 (en) 1991-08-29
JPH07303492A (ja) 1995-11-21
IE77159B1 (en) 1997-12-03
JP2798531B2 (ja) 1998-09-17
US5986073A (en) 1999-11-16
ZA911448B (en) 1992-02-26
DE69121742D1 (de) 1996-10-10
IE910661A1 (en) 1991-08-28
EP0445099A1 (de) 1991-09-04

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
EEIH Change in the person of patent owner
EEIH Change in the person of patent owner
EELA Cancelled due to lapse of time