DE69117519T2 - 14-o-p-chlorbenzoylaconin und analgetischer/entzündungshemmender wirkstoff - Google Patents
14-o-p-chlorbenzoylaconin und analgetischer/entzündungshemmender wirkstoffInfo
- Publication number
- DE69117519T2 DE69117519T2 DE69117519T DE69117519T DE69117519T2 DE 69117519 T2 DE69117519 T2 DE 69117519T2 DE 69117519 T DE69117519 T DE 69117519T DE 69117519 T DE69117519 T DE 69117519T DE 69117519 T2 DE69117519 T2 DE 69117519T2
- Authority
- DE
- Germany
- Prior art keywords
- chlorobenzoylaconine
- compound
- test compound
- salt
- analgesic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 150000003839 salts Chemical class 0.000 claims description 18
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 5
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 4
- 230000000694 effects Effects 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
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- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 3
- 229910052757 nitrogen Inorganic materials 0.000 description 3
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
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- 239000000829 suppository Substances 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 150000003892 tartrate salts Chemical class 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000002211 ultraviolet spectrum Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP03263354A JP3117251B2 (ja) | 1991-07-08 | 1991-07-08 | １４−Ｏ−ｐ−クロロベンゾイルアコニンおよび鎮痛・抗炎症剤 |
| PCT/JP1991/001298 WO1993001175A1 (fr) | 1991-07-08 | 1991-09-27 | 14-O-p-CHLOROBENZOYLACONINE ET AGENT ANALGESIQUE ET ANTI-INFLAMMATOIRE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69117519D1 DE69117519D1 (de) | 1996-04-04 |
| DE69117519T2 true DE69117519T2 (de) | 1996-07-11 |
Family
ID=17388317
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69117519T Expired - Lifetime DE69117519T2 (de) | 1991-07-08 | 1991-09-27 | 14-o-p-chlorbenzoylaconin und analgetischer/entzündungshemmender wirkstoff |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US5330983A (cg-RX-API-DMAC7.html) |
| EP (1) | EP0547224B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP3117251B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN1070852C (cg-RX-API-DMAC7.html) |
| DE (1) | DE69117519T2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1993001175A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5770604A (en) * | 1994-02-09 | 1998-06-23 | Sanwa Shoyaku Kabushiki Kaisha | Aconitine compound and an antipyretic/analgesic/anti-inflammatory agent |
| CN100443083C (zh) * | 2005-03-25 | 2008-12-17 | 成都高新区智爽天然产物科技有限责任公司 | 乌头胺在制药中的用途 |
| CN103570621B (zh) * | 2013-05-17 | 2015-04-29 | 万邦德制药集团股份有限公司 | 一种（-）-石杉碱甲的制备 |
| CN110092806B (zh) * | 2018-01-30 | 2022-05-17 | 中国医学科学院药物研究所 | 附子中具有镇痛作用的c19二萜生物碱糖苷及其用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0248526B2 (ja) * | 1980-02-26 | 1990-10-25 | Murayama Keikichi | Shinkinakoenshozai |
| JPH085862B2 (ja) * | 1987-02-27 | 1996-01-24 | 三和生薬株式会社 | 新規なアコニチン系化合物およびそれらを有効成分とする鎮痛・抗炎症剤 |
| JPH085863B2 (ja) * | 1987-02-27 | 1996-01-24 | 三和生薬株式会社 | １４−アニソイルアコニンおよびそれを有効成分とする新規な鎮痛・抗炎症剤 |
| JPH085865B2 (ja) * | 1987-04-06 | 1996-01-24 | 三和生薬株式会社 | 新規なアコニチン系化合物およびそれらを有効成分とする鎮痛・抗炎症剤 |
| JPH085864B2 (ja) * | 1987-05-08 | 1996-01-24 | 三和生薬株式会社 | 新規なアコニチン系化合物およびそれらを有効成分とする鎮痛・抗炎症剤 |
| JPH01254625A (ja) * | 1988-04-05 | 1989-10-11 | Tsumura & Co | 抗アレルギー剤 |
| JP3037991B2 (ja) * | 1989-12-21 | 2000-05-08 | 三和生薬株式会社 | 新規なアコニチン系化合物および鎮痛・抗炎症剤 |
-
1991
- 1991-07-08 JP JP03263354A patent/JP3117251B2/ja not_active Expired - Lifetime
- 1991-09-27 US US07/989,018 patent/US5330983A/en not_active Expired - Lifetime
- 1991-09-27 EP EP91916949A patent/EP0547224B1/en not_active Expired - Lifetime
- 1991-09-27 DE DE69117519T patent/DE69117519T2/de not_active Expired - Lifetime
- 1991-09-27 WO PCT/JP1991/001298 patent/WO1993001175A1/ja not_active Ceased
-
1992
- 1992-07-04 CN CN92105347A patent/CN1070852C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CN1068327A (zh) | 1993-01-27 |
| WO1993001175A1 (fr) | 1993-01-21 |
| EP0547224B1 (en) | 1996-02-28 |
| US5330983A (en) | 1994-07-19 |
| JP3117251B2 (ja) | 2000-12-11 |
| EP0547224A4 (cg-RX-API-DMAC7.html) | 1994-03-23 |
| CN1070852C (zh) | 2001-09-12 |
| JPH0517448A (ja) | 1993-01-26 |
| DE69117519D1 (de) | 1996-04-04 |
| EP0547224A1 (en) | 1993-06-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |