DE69031172D1 - Modifikation der endogenen genexpression mit hilfe eines regulatorischen elements mittels homologe rekombination - Google Patents

Modifikation der endogenen genexpression mit hilfe eines regulatorischen elements mittels homologe rekombination

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Publication number
DE69031172D1
DE69031172D1 DE69031172T DE69031172T DE69031172D1 DE 69031172 D1 DE69031172 D1 DE 69031172D1 DE 69031172 T DE69031172 T DE 69031172T DE 69031172 T DE69031172 T DE 69031172T DE 69031172 D1 DE69031172 D1 DE 69031172D1
Authority
DE
Germany
Prior art keywords
modification
gene expression
homologous recombination
regulatory element
endogenic gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69031172T
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English (en)
Other versions
DE69031172T2 (de
Inventor
Scott Chappel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Applied Research Systems ARS Holding NV
Original Assignee
Applied Research Systems ARS Holding NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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Application filed by Applied Research Systems ARS Holding NV filed Critical Applied Research Systems ARS Holding NV
Application granted granted Critical
Publication of DE69031172D1 publication Critical patent/DE69031172D1/de
Publication of DE69031172T2 publication Critical patent/DE69031172T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
DE69031172T 1989-12-22 1990-12-21 Modifikation der endogenen genexpression mit hilfe eines regulatorischen elements mittels homologe rekombination Expired - Fee Related DE69031172T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US45478389A 1989-12-22 1989-12-22
PCT/US1990/007642 WO1991009955A1 (en) 1989-12-22 1990-12-21 Endogenous gene expression modification with regulatory element

Publications (2)

Publication Number Publication Date
DE69031172D1 true DE69031172D1 (de) 1997-09-04
DE69031172T2 DE69031172T2 (de) 1998-03-12

Family

ID=23806064

Family Applications (3)

Application Number Title Priority Date Filing Date
DE69034135T Expired - Lifetime DE69034135T3 (de) 1989-12-22 1990-12-21 DNS-Konstrukten zur Aktivierung und Veränderung der Expression von endogenen Genen
DE69031172T Expired - Fee Related DE69031172T2 (de) 1989-12-22 1990-12-21 Modifikation der endogenen genexpression mit hilfe eines regulatorischen elements mittels homologe rekombination
DE0779362T Pending DE779362T1 (de) 1989-12-22 1990-12-21 DNS-Konstrukten zur Aktivierung und Veränderung der Expression von endogenen Genen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69034135T Expired - Lifetime DE69034135T3 (de) 1989-12-22 1990-12-21 DNS-Konstrukten zur Aktivierung und Veränderung der Expression von endogenen Genen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE0779362T Pending DE779362T1 (de) 1989-12-22 1990-12-21 DNS-Konstrukten zur Aktivierung und Veränderung der Expression von endogenen Genen

Country Status (26)

Country Link
EP (5) EP1484412A3 (de)
JP (3) JP3501286B2 (de)
KR (1) KR0176693B1 (de)
AR (1) AR245776A1 (de)
AT (2) ATE156189T1 (de)
AU (1) AU645294B2 (de)
BG (1) BG60624B1 (de)
BR (1) BR9007937A (de)
CA (1) CA2071989C (de)
DE (3) DE69034135T3 (de)
DK (2) DK0779362T4 (de)
ES (2) ES2104690T3 (de)
FI (1) FI107391B (de)
GR (1) GR3025057T3 (de)
HK (2) HK1000547A1 (de)
HU (1) HU217212B (de)
IL (4) IL116046A (de)
LT (1) LT3998B (de)
LV (1) LV10655B (de)
NO (1) NO311896B1 (de)
OA (1) OA09594A (de)
RO (1) RO109864B1 (de)
RU (1) RU2128227C1 (de)
UA (1) UA42675C2 (de)
WO (1) WO1991009955A1 (de)
ZA (1) ZA9010392B (de)

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