DE69006094T2 - Pharmazeutische Zusammensetzungen. - Google Patents
Pharmazeutische Zusammensetzungen.Info
- Publication number
- DE69006094T2 DE69006094T2 DE90304945T DE69006094T DE69006094T2 DE 69006094 T2 DE69006094 T2 DE 69006094T2 DE 90304945 T DE90304945 T DE 90304945T DE 69006094 T DE69006094 T DE 69006094T DE 69006094 T2 DE69006094 T2 DE 69006094T2
- Authority
- DE
- Germany
- Prior art keywords
- cgrp
- examples
- glycyrrhizinate
- hydroxybenzoate
- ammonium glycyrrhizinate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 3
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- 239000000203 mixture Substances 0.000 claims description 49
- 108090000932 Calcitonin Gene-Related Peptide Proteins 0.000 claims description 28
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- 238000010521 absorption reaction Methods 0.000 claims description 23
- 239000003795 chemical substances by application Substances 0.000 claims description 23
- 229940074774 glycyrrhizinate Drugs 0.000 claims description 12
- 239000003623 enhancer Substances 0.000 claims description 11
- 210000002850 nasal mucosa Anatomy 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 239000007921 spray Substances 0.000 claims description 5
- 239000003937 drug carrier Substances 0.000 claims description 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 105
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 54
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 51
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 41
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 41
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 40
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- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 34
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- DNKYDHSONDSTNJ-XJVRLEFXSA-N chembl1910953 Chemical compound C([C@@H](C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CS)NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(C)C)[C@@H](C)O)C1=CN=CN1 DNKYDHSONDSTNJ-XJVRLEFXSA-N 0.000 description 26
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- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 17
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- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 17
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- 229960002216 methylparaben Drugs 0.000 description 12
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- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 3
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- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 3
- 239000001685 glycyrrhizic acid Substances 0.000 description 3
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- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 3
- 235000019410 glycyrrhizin Nutrition 0.000 description 3
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- 239000007789 gas Substances 0.000 description 1
- 239000007903 gelatin capsule Substances 0.000 description 1
- 150000002302 glucosamines Chemical class 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- BWHLPLXXIDYSNW-UHFFFAOYSA-N ketorolac tromethamine Chemical compound OCC(N)(CO)CO.OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 BWHLPLXXIDYSNW-UHFFFAOYSA-N 0.000 description 1
- 229940010454 licorice Drugs 0.000 description 1
- 239000006193 liquid solution Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 239000007935 oral tablet Substances 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 229940055076 parasympathomimetics choline ester Drugs 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 208000001685 postmenopausal osteoporosis Diseases 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003248 quinolines Chemical class 0.000 description 1
- 150000003873 salicylate salts Chemical class 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
- WRZYGPIFICWRCG-OOFFSTKBSA-M sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4s,5s,6s)-2-[[(3s,4ar,6ar,6bs,8as,11s,12ar,14ar,14bs)-11-carboxylato-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1h-picen-3-yl]oxy]-6-carboxylato-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trih Chemical compound [Na+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O WRZYGPIFICWRCG-OOFFSTKBSA-M 0.000 description 1
- FIWQZURFGYXCEO-UHFFFAOYSA-M sodium;decanoate Chemical compound [Na+].CCCCCCCCCC([O-])=O FIWQZURFGYXCEO-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000013222 sprague-dawley male rat Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 239000006216 vaginal suppository Substances 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/225—Calcitonin gene related peptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (9)
1. Arzneimittel, umfassend ein Calcitonin-Gen-
verwandtes Peptid; eine wirksame Menge eines
Absorptionsverstärkers, welcher ein Glycyrrhizinat ist und
einen pharmazeutisch verträglichen Träger.
2. Mittel nach Anspruch 1, in dem das Glycyrrhizinat
Ammoniumglycyrrhizinat ist.
3. Mittel nach einem der Ansprüch 1 oder 2, in dem
das Glycyrrhizinat in einer Konzentration vorhanden ist, die
mindestens 0,1% (G/G) des Gesamtgewichts des Mittels
entspricht.
4. Mittel nach Anspruch 3, in dem die Konzentration
des Glycyrrhizinat 0,5 bis 5% (G/G) beträgt.
5. Mittel nach einem der Ansprüche 1 bis 4, in dem
das Calcitonin-Gen-verwandte Peptid h-CGRP ist.
6. Mittel nach einem der Ansprüche 1 bis 5 in Form
einer Flüssigkeit oder eines Gels, welches zum Auftragen auf
die Nasenschleimhaut geeignet ist.
7. Mittel nach Anspruch 6, in dem das Glycyrrhizinat
in einer Menge vorhanden ist, die etwa 2 g pro 100 ml Mittel
entspricht.
8. Mittel nach einem der Ansprüche 1 bis 7, das einen
pH-Wert im Bereich von etwa 4,5 bis etwa 6 hat.
9. Mittel nach einem der Ansprüche 1 bis 8, das zur
Verabreichung als Spray verpackt ist.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT8920486A IT8920486A0 (it) | 1989-05-12 | 1989-05-12 | Composizioni farmaceutiche. |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69006094D1 DE69006094D1 (de) | 1994-03-03 |
DE69006094T2 true DE69006094T2 (de) | 1994-05-05 |
Family
ID=11167674
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE90304945T Expired - Fee Related DE69006094T2 (de) | 1989-05-12 | 1990-05-08 | Pharmazeutische Zusammensetzungen. |
Country Status (5)
Country | Link |
---|---|
US (1) | US5122376A (de) |
EP (1) | EP0397447B1 (de) |
JP (1) | JPH035427A (de) |
DE (1) | DE69006094T2 (de) |
IT (1) | IT8920486A0 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9020544D0 (en) * | 1990-09-20 | 1990-10-31 | Sandoz Ltd | Improvements in or relating to organic compounds |
JPH0597680A (ja) * | 1991-10-04 | 1993-04-20 | Sanwa Kagaku Kenkyusho Co Ltd | グリチルリチン坐剤 |
FR2685205A1 (fr) * | 1991-12-23 | 1993-06-25 | Ardeval Laboratoires | Composition a base de plantes sous forme solide, son procede de preparation et ses applications. |
US5747445A (en) * | 1993-06-24 | 1998-05-05 | Astra Aktiebolag | Therapeutic preparation for inhalation |
US20010003739A1 (en) * | 1993-06-24 | 2001-06-14 | Astrazeneca Ab | Systemic administration of a therapeutic preparation |
US6632456B1 (en) | 1993-06-24 | 2003-10-14 | Astrazeneca Ab | Compositions for inhalation |
US6794357B1 (en) | 1993-06-24 | 2004-09-21 | Astrazeneca Ab | Compositions for inhalation |
US5830853A (en) * | 1994-06-23 | 1998-11-03 | Astra Aktiebolag | Systemic administration of a therapeutic preparation |
IS1796B (is) * | 1993-06-24 | 2001-12-31 | Ab Astra | Fjölpeptíð lyfjablanda til innöndunar sem einnig inniheldur eykjaefnasamband |
TW402506B (en) | 1993-06-24 | 2000-08-21 | Astra Ab | Therapeutic preparation for inhalation |
US5567679A (en) * | 1993-12-13 | 1996-10-22 | Daly; Theodore J. | Use of CGRP in treating alopecia |
US6165976A (en) | 1994-06-23 | 2000-12-26 | Astra Aktiebolag | Therapeutic preparation for inhalation |
EE9700138A (et) | 1994-12-22 | 1997-12-15 | Astra Aktiebolag | Aerosoolravimvormid |
SK76797A3 (en) * | 1994-12-22 | 1998-02-04 | Astra Ab | Therapeutic preparation for inhalation containing parathyroid hormone, pth |
US6524557B1 (en) | 1994-12-22 | 2003-02-25 | Astrazeneca Ab | Aerosol formulations of peptides and proteins |
US5904935A (en) * | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
US5912014A (en) * | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
AU2001249207B2 (en) * | 2000-03-14 | 2004-11-18 | National Jewish Medical And Research Center | Method for reducing allergen-induced airway hyperresponsiveness |
US8088734B2 (en) * | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
US20050282756A1 (en) * | 2004-06-18 | 2005-12-22 | Mehta Nozer M | Oral delivery of peptide pharmaceutical compositions |
JP4844375B2 (ja) * | 2005-12-09 | 2011-12-28 | パナソニック電工株式会社 | 浴槽装置 |
AR071706A1 (es) * | 2008-05-15 | 2010-07-07 | Otsuka Pharma Co Ltd | Una formulacion farmaceutica de cilostazol solida de liberacion sostenida y metodo de preparacion. |
GB0904942D0 (en) * | 2009-03-23 | 2009-05-06 | Ntnu Technology Transfer As | Composition |
WO2013067309A1 (en) * | 2011-11-04 | 2013-05-10 | Xion Pharmaceutical Corporation | Methods and compositions for oral administration of melanocortin receptor agonist compounds |
Family Cites Families (36)
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---|---|---|---|---|
CH532452A (de) * | 1970-07-02 | 1973-01-15 | Esterol Ag | Verfahren zur Herstellung von kunstharzgebundenen Formkörpern, insbesondere von polyestergebundenen Schleifkörpern |
CH594608A5 (de) * | 1973-12-14 | 1978-01-13 | Ciba Geigy Ag | |
US3988309A (en) * | 1973-12-27 | 1976-10-26 | Toyo Jozo Kabushiki Kaisha | EEL calcitonin |
JPS51128993A (en) * | 1975-05-01 | 1976-11-10 | Tanpakushitsu Kenkyu Shiyoureikai | Process for preparing new polypeptides |
GB2008403B (en) * | 1977-11-04 | 1982-07-28 | Christie R B Parsons J A | Pharmaceutical compositions |
US4304692A (en) * | 1978-07-24 | 1981-12-08 | Armour Pharmaceutical Company | Synthesis of biologically active peptides |
GB2042888B (en) * | 1979-03-05 | 1983-09-28 | Teijin Ltd | Preparation for administration to the mucosa of the oral or nasal cavity |
GB2050825B (en) * | 1979-06-14 | 1983-07-27 | Kanebo Ltd | Creamy or milky skin cosmetic compositions |
JPS6034925B2 (ja) * | 1979-07-31 | 1985-08-12 | 帝人株式会社 | 持続性鼻腔用製剤およびその製造法 |
US4393200A (en) * | 1980-01-09 | 1983-07-12 | Maruzen Kasei Kabushiki Kaisha | 18 α-Glycyrrhizinic acid and salt thereof |
GB2071494B (en) * | 1980-03-08 | 1984-05-31 | Maruzen Kasei Co Ltd | Cosmetics containing 18-glycyrrhizins |
EP0037943B1 (de) * | 1980-03-31 | 1985-08-14 | Teijin Limited | Pharmazeutische Zusammensetzung zur rektalen Verabreichung und daraus hergestellte Zäpfchen |
IL65184A0 (en) * | 1982-03-05 | 1982-05-31 | Yissum Res Dev Co | Preparation for the treatment of oral diseases,comprising glycyrrhizin |
EP0094157B1 (de) * | 1982-04-30 | 1987-07-29 | Takeda Chemical Industries, Ltd. | Pharmazeutische Zusammensetzung und ihre Verwendung |
GB2127689B (en) * | 1982-10-05 | 1986-07-09 | Sandoz Ltd | Calcitonin inhalation compositions |
US4476116A (en) * | 1982-12-10 | 1984-10-09 | Syntex (U.S.A.) Inc. | Polypeptides/chelating agent nasal compositions having enhanced peptide absorption |
AU572815B2 (en) * | 1982-12-29 | 1988-05-19 | Armour Pharmaceutical Company | Pharmaceutical calcitonin compositions for intranasal application |
JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
IL68769A (en) * | 1983-05-23 | 1986-02-28 | Hadassah Med Org | Pharmaceutical compositions containing insulin for oral administration |
US4548922A (en) * | 1983-06-06 | 1985-10-22 | Beth Israel Hospital | Drug administration |
US4530838A (en) * | 1983-07-08 | 1985-07-23 | The Salk Institute For Biological Studies | Synthetic calcitonin-gene-related peptides for lowering blood pressure or gastric acid secretion in mammals |
EP0187433B1 (de) * | 1983-08-01 | 1990-12-27 | Teijin Limited | Pulverige pharmazeutische Zusammensetzung zur Anwendung auf die Schleimhaut der Mund- oder Nasenhöhle |
JPS6032714A (ja) * | 1983-08-01 | 1985-02-19 | Teijin Ltd | 鼻腔粘膜に適用するための安定化された粉末状薬学的組成物 |
US4597900A (en) * | 1983-08-22 | 1986-07-01 | Armour Pharmaceutical Co. | Des2 -glycine8 -des22 -calcitonin |
JPS60100516A (ja) * | 1983-11-04 | 1985-06-04 | Takeda Chem Ind Ltd | 徐放型マイクロカプセルの製造法 |
US4549986A (en) * | 1983-12-23 | 1985-10-29 | The Salk Institute For Biological Studies | Human CGRP |
GB8407907D0 (en) * | 1984-03-27 | 1984-05-02 | Sandoz Ltd | Organic compounds |
JPS6160620A (ja) * | 1984-09-03 | 1986-03-28 | Teijin Ltd | ピログルタミン酸エステル類を含有する医薬品組成物 |
JPS61126034A (ja) * | 1984-11-26 | 1986-06-13 | Yamanouchi Pharmaceut Co Ltd | アルド−スを含有するカルシトニン経鼻剤 |
JPS61267528A (ja) * | 1984-11-26 | 1986-11-27 | Yamanouchi Pharmaceut Co Ltd | 吸収促進剤を含有するカルシトニン経鼻剤 |
US4692441A (en) * | 1985-08-16 | 1987-09-08 | Merck & Co., Inc. | Chorine esters as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal cavities |
US4731360A (en) * | 1985-08-16 | 1988-03-15 | Merck & Co., Inc. | Acylcarnitines as absorption-enhancing agents for drug delivery through mucous membranes of the nasal, buccal, sublingual and vaginal compartments |
NZ222907A (en) * | 1986-12-16 | 1990-08-28 | Novo Industri As | Preparation for intranasal administration containing a phospholipid absorption enhancing system |
JPH085800B2 (ja) * | 1986-12-19 | 1996-01-24 | エーザイ株式会社 | 塩化リゾチ−ム及びグリチルリチン酸ジカリウム含有水溶液製剤 |
CA1335076C (en) * | 1987-04-01 | 1995-04-04 | Hanna R. Kowarski | Pharmaceutical composition and method for intranasal administration |
IT1223132B (it) * | 1987-11-13 | 1990-09-12 | Isf Spa | Composizione farmaceutica per somministrazione nasale |
-
1989
- 1989-05-12 IT IT8920486A patent/IT8920486A0/it unknown
-
1990
- 1990-05-08 DE DE90304945T patent/DE69006094T2/de not_active Expired - Fee Related
- 1990-05-08 EP EP90304945A patent/EP0397447B1/de not_active Expired - Lifetime
- 1990-05-09 US US07/521,288 patent/US5122376A/en not_active Expired - Fee Related
- 1990-05-14 JP JP2123967A patent/JPH035427A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP0397447B1 (de) | 1994-01-19 |
IT8920486A0 (it) | 1989-05-12 |
JPH035427A (ja) | 1991-01-11 |
US5122376A (en) | 1992-06-16 |
DE69006094D1 (de) | 1994-03-03 |
EP0397447A1 (de) | 1990-11-14 |
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