DE68916983T2 - Verfahren zur Herstellung eines pharmazeutischen Granulats. - Google Patents

Verfahren zur Herstellung eines pharmazeutischen Granulats.

Info

Publication number
DE68916983T2
DE68916983T2 DE68916983T DE68916983T DE68916983T2 DE 68916983 T2 DE68916983 T2 DE 68916983T2 DE 68916983 T DE68916983 T DE 68916983T DE 68916983 T DE68916983 T DE 68916983T DE 68916983 T2 DE68916983 T2 DE 68916983T2
Authority
DE
Germany
Prior art keywords
manufacture
granulate
wet
pharmaceutical granules
microcrystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68916983T
Other languages
English (en)
Other versions
DE68916983D1 (de
Inventor
Margaretha Olthoff
Bernardus Leonardus Dijkgraaf
Piet Johannes Akkerboom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Pharma Europe BV
Original Assignee
Yamanouchi Europe BV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yamanouchi Europe BV filed Critical Yamanouchi Europe BV
Publication of DE68916983D1 publication Critical patent/DE68916983D1/de
Application granted granted Critical
Publication of DE68916983T2 publication Critical patent/DE68916983T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
DE68916983T 1988-02-25 1989-02-20 Verfahren zur Herstellung eines pharmazeutischen Granulats. Expired - Lifetime DE68916983T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP88200346 1988-02-25

Publications (2)

Publication Number Publication Date
DE68916983D1 DE68916983D1 (de) 1994-09-01
DE68916983T2 true DE68916983T2 (de) 1995-01-19

Family

ID=8199757

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68916983T Expired - Lifetime DE68916983T2 (de) 1988-02-25 1989-02-20 Verfahren zur Herstellung eines pharmazeutischen Granulats.

Country Status (17)

Country Link
US (1) US5085869A (de)
EP (1) EP0330284B1 (de)
JP (1) JP2939262B2 (de)
KR (1) KR0135289B1 (de)
CN (1) CN1048395C (de)
AT (1) ATE108996T1 (de)
AU (1) AU611999B2 (de)
CA (1) CA1338553C (de)
DE (1) DE68916983T2 (de)
DK (1) DK175306B1 (de)
ES (1) ES2060737T3 (de)
FI (1) FI100219B (de)
IE (1) IE69366B1 (de)
IL (1) IL89378A (de)
NO (1) NO178485C (de)
NZ (1) NZ228122A (de)
PT (1) PT89823B (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1246188B (it) * 1990-07-27 1994-11-16 Resa Farma Procedimento per la preparazione di composizioni farmaceutiche aventi aumentata velocita' di dissoluzione della sostanza attiva e composizioni ottenute.
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
NL9220009A (nl) * 1991-01-30 1993-11-01 Wellcome Found In water-dispergeerbare tabletten.
JP3069458B2 (ja) * 1992-01-29 2000-07-24 武田薬品工業株式会社 口腔内崩壊型錠剤およびその製造法
DE59307753D1 (de) * 1992-03-11 1998-01-15 Asta Medica Ag Tabletten, Granulate und Pellets mit hohem Gehalt an Wirkstoffen für hochkonzentrierte, feste Darreichungsformen
JP2964195B2 (ja) * 1992-04-28 1999-10-18 エスエス製薬株式会社 ピロキシカム錠及びその製造法
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
IL115445A (en) * 1994-10-17 1999-08-17 Akzo Nobel Nv Solid pharmaceutical compositions comprising low dosage active ingredient oil and excipient capable of binding water and their preparation
SE504902C2 (sv) * 1994-11-02 1997-05-26 Diabact Ab Beredning för påvisande av Helicobacter pylori i magsäcken
MX9706062A (es) * 1995-02-08 1997-10-31 Yamanouchi Europ Bv FORMAS DE DOSIFICACION ORAL CONTENIENDO UN ANTIBIOTICO DE beta -LACTAMA.
TWI225402B (en) * 1996-03-13 2004-12-21 Biochemie Gmbh Auxiliary-free agglomerates
US5837292A (en) * 1996-07-03 1998-11-17 Yamanouchi Europe B.V. Granulate for the preparation of fast-disintegrating and fast-dissolving compositions containing a high amount of drug
SK3999A3 (en) * 1996-07-16 1999-07-12 Gist Brocades Nv 'beta'-lactam granules free of organic solvents
TR199900296T2 (xx) * 1996-08-14 1999-06-21 Yamanouchi Europe B.V. Suda ��z�n�r bir bile�ik ve sel�loz i�eren gran�ler �r�nler
JPH11506473A (ja) * 1997-02-25 1999-06-08 ザ、プロクター、エンド、ギャンブル、カンパニー 湿式粒状化方法
US5785995A (en) * 1997-04-11 1998-07-28 Upsher-Smith Laboratories, Inc. Pharmaceutical tablet of amiodarone salt
GB9720061D0 (en) * 1997-09-19 1997-11-19 Crosfield Joseph & Sons Metal compounds as phosphate binders
WO1999018965A1 (en) * 1997-10-10 1999-04-22 Yamanouchi Europe B.V. Oral compositions containing a cephalosporin antibiotic
FR2772617B1 (fr) * 1997-12-19 2001-03-09 Besins Iscovesco Lab Comprime de progesterone et son procede de preparation
NZ553010A (en) * 1998-12-23 2008-09-26 Novartis Ag Use of AT-1 receptor antagonist or AT-2 receptor modulator for treating diseases associated with an increase of AT-1 or AT-2 receptors
EA003052B1 (ru) 1999-07-27 2002-12-26 Балканфарма Холдинг АД Антиаритмическое лекарственное средство
AR028253A1 (es) * 2000-03-16 2003-04-30 Pfizer Prod Inc Inhibidores de la glucogeno fosforilasa
US20040213839A1 (en) * 2001-02-05 2004-10-28 Andrew Favara Methods and compositions for reducing the taste of pharmaceutically active agents
BR0307516A (pt) * 2002-02-01 2004-12-07 Pfizer Prod Inc Formas de dosagem de liberação imediata contendo dispersões de uma droga sólida
US6958161B2 (en) * 2002-04-12 2005-10-25 F H Faulding & Co Limited Modified release coated drug preparation
US20050008691A1 (en) * 2003-05-14 2005-01-13 Arturo Siles Ortega Bicalutamide compositions
MY157620A (en) * 2006-01-31 2016-06-30 Cytochroma Dev Inc A granular material of a solid water-soluble mixed metal compound capable of binding phosphate
US8617597B2 (en) 2006-07-06 2013-12-31 Bayer Intellectual Property Gmbh Pharmaceutical composition containing a tetrahydrofolic acid
GB0714670D0 (en) * 2007-07-27 2007-09-05 Ineos Healthcare Ltd Use
GB0720220D0 (en) * 2007-10-16 2007-11-28 Ineos Healthcare Ltd Compound
GB0913525D0 (en) 2009-08-03 2009-09-16 Ineos Healthcare Ltd Method
GB201001779D0 (en) 2010-02-04 2010-03-24 Ineos Healthcare Ltd Composition
FR2991179B1 (fr) * 2012-06-01 2016-11-11 Ceva Sante Animale Compositions veterinaires orales appetentes
US20190167592A1 (en) * 2016-07-13 2019-06-06 Gangwal Chemicals Private Limited Process for directly compressible co-processed excipient for modified release application

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5438167B2 (de) * 1974-04-27 1979-11-19
JPS5562012A (en) * 1978-11-06 1980-05-10 Teijin Ltd Slow-releasing preparation
GB2058565B (en) * 1979-09-21 1983-12-07 Leo Pharm Prod Ltd Layer tablets
NZ198241A (en) * 1980-09-27 1983-12-16 Beecham Group Ltd Tablet containing amoxycillin and potassium clavulanate
NZ199931A (en) * 1981-03-13 1985-02-28 Lilly Co Eli Method for formulating medicated animal feed premix comprising a synthetic drug
JPS5839618A (ja) * 1981-09-04 1983-03-08 Chugai Pharmaceut Co Ltd 持続性積層錠剤
DE3266580D1 (en) * 1981-12-02 1985-10-31 Beecham Group Plc Pharmaceutical formulation comprising beta-lactam antibiotics
JPS59101423A (ja) * 1982-12-02 1984-06-12 Takada Seiyaku Kk 新規なニフエジピン固形製剤
JPS6097919A (ja) * 1983-11-01 1985-05-31 Furointo Sangyo Kk 圧縮成形用賦形剤の製造方法
NL8400911A (nl) * 1984-03-22 1985-10-16 Dagra Nv Werkwijze ter bereiding van een farmaceutische toedieningsvorm die tetracycline of doxycyclinezouten bevat.
DE3681348D1 (de) * 1985-06-11 1991-10-17 Teijin Ltd Oral-arzneizubereitung mit retardwirkung.
US4753801A (en) * 1985-10-25 1988-06-28 Eli Lilly And Company Sustained release tablets
GB8618811D0 (en) * 1986-08-01 1986-09-10 Approved Prescription Services Sustained release ibuprofen formulation
EP0281200B1 (de) * 1987-03-02 1994-01-19 Yamanouchi Europe B.V. Pharmazeutische Zusammensetzung, pharmazeutisches Granulat und Verfahren zu ihrer Herstellung
US4837031A (en) * 1987-09-17 1989-06-06 Mallinckrodt, Inc. Compositions containing ibuprofen
US4837030A (en) * 1987-10-06 1989-06-06 American Cyanamid Company Novel controlled release formulations of tetracycline compounds

Also Published As

Publication number Publication date
DE68916983D1 (de) 1994-09-01
CN1048395C (zh) 2000-01-19
PT89823A (pt) 1989-10-04
DK175306B1 (da) 2004-08-16
NZ228122A (en) 1991-04-26
JP2939262B2 (ja) 1999-08-25
FI890884A0 (fi) 1989-02-24
IL89378A0 (en) 1989-09-10
JPH023606A (ja) 1990-01-09
DK86389A (da) 1989-08-26
AU611999B2 (en) 1991-06-27
AU3015889A (en) 1989-08-31
CN1035433A (zh) 1989-09-13
NO890789L (no) 1989-08-28
PT89823B (pt) 1994-04-29
FI100219B (fi) 1997-10-31
DK86389D0 (da) 1989-02-24
US5085869A (en) 1992-02-04
EP0330284B1 (de) 1994-07-27
CA1338553C (en) 1996-08-27
EP0330284A2 (de) 1989-08-30
KR900012603A (ko) 1990-09-01
IL89378A (en) 1993-01-31
IE890545L (en) 1989-08-25
KR0135289B1 (ko) 1998-04-23
ES2060737T3 (es) 1994-12-01
NO178485C (no) 1996-04-10
FI890884A (fi) 1989-08-26
NO178485B (no) 1996-01-02
NO890789D0 (no) 1989-02-24
IE69366B1 (en) 1996-09-04
ATE108996T1 (de) 1994-08-15
EP0330284A3 (en) 1990-11-07

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: YAMANOUCHI EUROPE B.V., LEIDERDROP, NL

8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ASTELLAS PHARMA EUROPE B.V., LEIDERDORP, NL