ES2055177T3 - Composicion de gemfibrozil con liberacion modificada. - Google Patents

Composicion de gemfibrozil con liberacion modificada.

Info

Publication number
ES2055177T3
ES2055177T3 ES90102022T ES90102022T ES2055177T3 ES 2055177 T3 ES2055177 T3 ES 2055177T3 ES 90102022 T ES90102022 T ES 90102022T ES 90102022 T ES90102022 T ES 90102022T ES 2055177 T3 ES2055177 T3 ES 2055177T3
Authority
ES
Spain
Prior art keywords
granulation
gemfibrozil
pharmaceutically acceptable
finely divided
divided particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90102022T
Other languages
English (en)
Inventor
Isaac Ghebre-Sellassie
Robert Harry Gordon
Sadath U Khan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2055177T3 publication Critical patent/ES2055177T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Dental Preparations (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

UNA FORMULACION DE GEMFIBROCIL DESINTEGRABLE DANDO INMEDIATAS REALIZACIONES Y QUE COMPRENDE UNA TABLETA DE UNA MEZCLA DE UNA PRIMERA Y SEGUNDA GRANULACION, Y UN EXCIPIENTE DE DESINTEGRACION OPERABLE PARA UN EFECTO PARCIAL O PARA LA DESINTEGRACION COMPLETA EN EL ESTOMAGO. LA PRIMERA GRANULACION COMPRENDE UNAS PARTICULAS FINAMENTE DIVIDIDAS DE GEMFIBROCIL PURO GRANULADO, CON AL MENOS UN DERIVADO DE CELULOSA, Y LA SEGUNDA GRANULACION COMPRENDE LAS MISMAS PARTICULAS CON AGUA SOLUBLE FARMACEUTICAMENTE ACEPTABLE, O UN POLIMERO INSOLUBLE QUE ESTA RECUBIERTO UNIFORMEMENTE CON UN COPOLIMERO DE METACRILATO FARMACEUTICAMENTE ACEPTABLE, ANTES QUE CON LA MEZCLA DE LA PRIMERA GRANULACION. LA PRIMERA Y SEGUNDA GRANULACIONES ESTAN PRESENTES EN EL COMPUESTO FINAL EN UNA PROPORCION DE APROXIMADAMENTE UN 10:1 A 1:10.
ES90102022T 1989-02-02 1990-02-01 Composicion de gemfibrozil con liberacion modificada. Expired - Lifetime ES2055177T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/305,082 US4927639A (en) 1989-02-02 1989-02-02 Modified release gemfibrozil composition

Publications (1)

Publication Number Publication Date
ES2055177T3 true ES2055177T3 (es) 1994-08-16

Family

ID=23179253

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90102022T Expired - Lifetime ES2055177T3 (es) 1989-02-02 1990-02-01 Composicion de gemfibrozil con liberacion modificada.

Country Status (21)

Country Link
US (1) US4927639A (es)
EP (1) EP0381219B1 (es)
JP (1) JPH02240017A (es)
KR (1) KR0137268B1 (es)
CN (1) CN1053744A (es)
AT (1) ATE88889T1 (es)
AU (1) AU622751B2 (es)
CA (1) CA2009135A1 (es)
DE (1) DE69001488T2 (es)
DK (1) DK0381219T3 (es)
ES (1) ES2055177T3 (es)
FI (1) FI900491A0 (es)
HU (1) HU204192B (es)
IE (1) IE900371L (es)
IL (1) IL92994A (es)
MY (1) MY104898A (es)
NO (1) NO900484L (es)
NZ (1) NZ232321A (es)
PH (1) PH26317A (es)
PT (1) PT93029A (es)
ZA (1) ZA90776B (es)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5331756A (en) * 1988-05-04 1994-07-26 Rehrig International, Inc. Basket wall with placard display assembly
EP0462067A1 (en) * 1990-06-15 1991-12-18 Warner-Lambert Company Gemfibrozil formulations
EP0462066A1 (en) * 1990-06-15 1991-12-18 Warner-Lambert Company Amorphous gemfibrozil
EP0475894A1 (en) * 1990-08-27 1992-03-18 Warner-Lambert Company Gemfibrozil formulations
US5102668A (en) * 1990-10-05 1992-04-07 Kingaform Technology, Inc. Sustained release pharmaceutical preparation using diffusion barriers whose permeabilities change in response to changing pH
US5629016A (en) * 1991-01-30 1997-05-13 Glaxo Wellcome Inc. Water-dispersible tablets
ES2080641B1 (es) * 1991-01-30 1996-11-01 Wellcome Found Procedimiento para preparar comprimidos dispersables en agua.
US5358723A (en) * 1991-11-26 1994-10-25 Warner-Lambert Company Process and composition for the development of controlled release gemfibrozil dosage form
US5492700A (en) * 1991-11-26 1996-02-20 Warner-Lambert Company Process and composition for the development of controlled release gemfibrozil dosage form
EP0614358A1 (en) * 1991-11-26 1994-09-14 Warner-Lambert Company Process and composition for the development of controlled release gemfibrozil dosage form
GB9215908D0 (en) * 1992-07-27 1992-09-09 Wellcome Found Water dispersible tablets
US5698226A (en) * 1993-07-13 1997-12-16 Glaxo Wellcome Inc. Water-dispersible tablets
DE4333190C2 (de) * 1993-09-29 1996-05-30 Korsatko Werner Univ Prof Dr E Zerbeißtablette mit verzögerter Wirkstoff-Freisetzung
US5451409A (en) * 1993-11-22 1995-09-19 Rencher; William F. Sustained release matrix system using hydroxyethyl cellulose and hydroxypropyl cellulose polymer blends
US6103262A (en) * 1994-01-27 2000-08-15 G. D. Searle & Company Modified-release metronidazole compositions and methods for making and using same
HU212428B (en) * 1994-05-13 1996-06-28 Egyt Gyogyszervegyeszeti Gyar Process to prepare pharmaceutical compositions containing gemfibrozyl
PT932388E (pt) * 1996-09-30 2006-07-31 Alza Corp Forma de dosagem e metodo para administracao de farmacos
EP1690531A3 (en) * 1996-09-30 2010-01-20 Alza Corporation Dosage form and method for administering drug
US6919373B1 (en) 1996-11-12 2005-07-19 Alza Corporation Methods and devices for providing prolonged drug therapy
FR2758459B1 (fr) * 1997-01-17 1999-05-07 Pharma Pass Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation
US7014864B1 (en) 1998-12-18 2006-03-21 Abbott Laboratories Formulations comprising lipid-regulating agents
US6838091B2 (en) 1998-12-18 2005-01-04 Abbott Laboratories Formulations comprising lipid-regulating agents
US6814977B1 (en) 1998-12-18 2004-11-09 Abbott Laboratories Formulations comprising lipid-regulating agents
US6719999B2 (en) 1999-03-31 2004-04-13 Abbott Laboratories Formulations comprising lipid-regulating agents
US6465011B2 (en) 1999-05-29 2002-10-15 Abbott Laboratories Formulations comprising lipid-regulating agents
US6372251B2 (en) 1999-06-11 2002-04-16 Abbott Laboratories Formulations comprising lipid-regulating agents
TW200404544A (en) * 2002-06-17 2004-04-01 Kowa Co Controlled release pharmaceutical composition
US20050265955A1 (en) * 2004-05-28 2005-12-01 Mallinckrodt Inc. Sustained release preparations
US20070212416A1 (en) * 2004-06-10 2007-09-13 Glatt Air Techniques, Inc. Controlled Release Matrix Pharmaceutical Dosage Formulation
FI125478B (fi) * 2010-03-30 2015-10-30 Pertti Neuvonen Farmaseuttinen koostumus, joka sisältää gemfibrotsiiliä ja CYP2C8- ja/tai OATP-substraattilääkettä
US9425525B2 (en) * 2014-09-22 2016-08-23 Amphenol InterCon Systems, Inc. Interposer assembly and method
FI4037666T3 (fi) 2020-12-08 2024-06-24 Ruminant Biotech Corp Ltd Parannuksia laitteisiin ja menetelmiin aineiden toimittamiseksi eläimille

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4132753A (en) * 1965-02-12 1979-01-02 American Cyanamid Company Process for preparing oral sustained release granules
US4291016A (en) * 1976-07-27 1981-09-22 Sandoz Ltd. Enteric coated mixture of 4-(2-hydroxy-3-isopropylamino-propoxy) indole and sodium lauryl sulphate
US4195084A (en) * 1977-01-07 1980-03-25 Eli Lilly And Company Taste-stable aqueous pharmaceutical suspension of tall oil sitosterols and a method for the preparation thereof
IT1101649B (it) * 1978-12-15 1985-10-07 Lehner Ag Composizione farmaceutica ad azione prolungata contenente acidi biliari
JPS57171428A (en) * 1981-04-13 1982-10-22 Sankyo Co Ltd Preparation of coated solid preparation
JPS59193831A (ja) * 1983-04-18 1984-11-02 Sankyo Co Ltd 腸溶性製剤の製造法
HU190619B (en) * 1983-11-11 1986-09-29 Bezzegh,Denes,Hu Process for producing tablets with controlled dissolution of active ingredients
CH658188A5 (de) * 1984-03-23 1986-10-31 Ciba Geigy Ag Lagerstabile schnellzerfallende pharmazeutische presslinge.
JPS6144811A (ja) * 1984-08-10 1986-03-04 Ss Pharmaceut Co Ltd 徐放性ジクロフエナクナトリウム製剤
DE3678644D1 (de) * 1985-08-16 1991-05-16 Procter & Gamble Wirkstoffpartikel mit sowohl kontinuierlicher als auch schneller freisetzung.
US4778676A (en) * 1985-12-20 1988-10-18 Warner-Lambert Company Confectionery delivery system for actives
US4716033A (en) * 1986-03-27 1987-12-29 Warner-Lambert Company Medicament adsorbates with surfactant and their preparation
US4816264A (en) * 1986-06-06 1989-03-28 Warner-Lambert Company Sustained release formulations
IT1200178B (it) * 1986-07-23 1989-01-05 Alfa Farmaceutici Spa Formulazioni galeniche a cessione programmata contenenti farmaci ad attivita' antiflogistica
US4814354A (en) * 1986-09-26 1989-03-21 Warner-Lambert Company Lipid regulating agents
AU1422388A (en) * 1987-01-27 1988-08-10 Warner-Lambert Company Lipid regulating compositions

Also Published As

Publication number Publication date
IE900371L (en) 1990-08-02
PT93029A (pt) 1990-08-31
KR0137268B1 (ko) 1998-04-25
KR900012604A (ko) 1990-09-01
CN1053744A (zh) 1991-08-14
EP0381219A2 (en) 1990-08-08
US4927639A (en) 1990-05-22
NO900484L (no) 1990-08-03
NO900484D0 (no) 1990-02-01
MY104898A (en) 1994-06-30
FI900491A0 (fi) 1990-01-31
IL92994A0 (en) 1990-09-17
HU204192B (en) 1991-12-30
HU900638D0 (en) 1990-04-28
IL92994A (en) 1994-04-12
NZ232321A (en) 1991-02-26
ATE88889T1 (de) 1993-05-15
DE69001488T2 (de) 1993-08-26
DE69001488D1 (de) 1993-06-09
CA2009135A1 (en) 1990-08-02
EP0381219B1 (en) 1993-05-05
AU622751B2 (en) 1992-04-16
EP0381219A3 (en) 1990-12-05
ZA90776B (en) 1991-10-30
PH26317A (en) 1992-04-29
DK0381219T3 (da) 1993-06-01
JPH02240017A (ja) 1990-09-25
AU4899290A (en) 1990-08-09
HUT52950A (en) 1990-09-28

Similar Documents

Publication Publication Date Title
ES2055177T3 (es) Composicion de gemfibrozil con liberacion modificada.
EP0157695B1 (en) Controlled release solid drug dosage forms based on mixtures of water soluble nonionic cellulose ethers and anionic surfactants
EP0322222B1 (en) Sustained release drug dosage forms containing hydroxypropylmethylcellulose and alkali metal carboxylates
US4540566A (en) Prolonged release drug dosage forms based on modified low viscosity grade hydroxypropylmethylcellulose
KR890001526A (ko) 경구용 서방성 아세트 아미노펜 제형 및 이의 제조방법
KR880010757A (ko) 제약정제, 제약과립 및 그의 제조방법
NZ336789A (en) Use of methacrylic acid copolymer type C in the manufacture of tablets
DE3877764D1 (de) Ein freifliessendes granulat, enthaltend ibuprofen und ein herstellunsgverfahren.
AU7992987A (en) Method and formulation for orally administering bioactive agents to and through the peyer's patch
NZ228122A (en) Pharmaceutical granulate containing cellulose substance and wet-binding agent; dosage form and process for preparation
MY104010A (en) Pharmaceutical compositions.
IL92995A0 (en) Pharmaceutical compositions comprising gemfibrozil
CA2055905A1 (en) Pharmaceutical composition comprising calcium polycarbophil
GEP20033078B (en) Controlled-Release Compositions of Betahistine
EP0297866A3 (en) Therapeutic agents
CA2361496A1 (en) Ph independent extended release pharmaceutical formulation
JPS5781409A (en) External plaster

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 381219

Country of ref document: ES