DE60317529T2 - Imidazopyridine als hemmstoffe cyclin abhängiger kinasen - Google Patents

Imidazopyridine als hemmstoffe cyclin abhängiger kinasen Download PDF

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Publication number
DE60317529T2
DE60317529T2 DE60317529T DE60317529T DE60317529T2 DE 60317529 T2 DE60317529 T2 DE 60317529T2 DE 60317529 T DE60317529 T DE 60317529T DE 60317529 T DE60317529 T DE 60317529T DE 60317529 T2 DE60317529 T2 DE 60317529T2
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DE
Germany
Prior art keywords
cancer
pharmaceutically acceptable
compounds
cyclin
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60317529T
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German (de)
English (en)
Other versions
DE60317529D1 (de
Inventor
Michael P. Scotch Plains DWYER
Timothy J. Chatham GUZI
Kamil Kenilworth PARUCH
Ronald J. Convent Station DOLL
Kartik M. East Windsor KEERTIKAR
Viyyoor M. Parsippany GIRIJAVALLABHAN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
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Publication date
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Publication of DE60317529D1 publication Critical patent/DE60317529D1/de
Publication of DE60317529T2 publication Critical patent/DE60317529T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60317529T 2002-09-19 2003-09-17 Imidazopyridine als hemmstoffe cyclin abhängiger kinasen Expired - Lifetime DE60317529T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41206302P 2002-09-19 2002-09-19
US412063P 2002-09-19
PCT/US2003/029498 WO2004026867A2 (en) 2002-09-19 2003-09-17 Imidazopyridines as cyclin dependent kinase inhibitors

Publications (2)

Publication Number Publication Date
DE60317529D1 DE60317529D1 (de) 2007-12-27
DE60317529T2 true DE60317529T2 (de) 2008-09-25

Family

ID=32030794

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60317529T Expired - Lifetime DE60317529T2 (de) 2002-09-19 2003-09-17 Imidazopyridine als hemmstoffe cyclin abhängiger kinasen

Country Status (18)

Country Link
US (2) US6992080B2 (https=)
EP (1) EP1539756B1 (https=)
JP (1) JP4845379B2 (https=)
KR (1) KR20050052500A (https=)
CN (1) CN100549011C (https=)
AR (1) AR041291A1 (https=)
AT (1) ATE378336T1 (https=)
AU (1) AU2003295332B2 (https=)
CA (1) CA2499639C (https=)
DE (1) DE60317529T2 (https=)
ES (1) ES2293068T3 (https=)
IL (1) IL167433A (https=)
MX (1) MXPA05003058A (https=)
MY (1) MY133311A (https=)
NZ (1) NZ538566A (https=)
TW (1) TWI351405B (https=)
WO (1) WO2004026867A2 (https=)
ZA (1) ZA200502278B (https=)

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US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
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EA021293B1 (ru) 2008-12-08 2015-05-29 Джилид Коннектикут, Инк. ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
CN102307474B (zh) 2008-12-08 2015-04-01 吉利德康涅狄格股份有限公司 咪唑并吡嗪syk抑制剂
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Also Published As

Publication number Publication date
AU2003295332B2 (en) 2007-01-18
NZ538566A (en) 2008-02-29
CN100549011C (zh) 2009-10-14
AU2003295332A1 (en) 2004-04-08
EP1539756B1 (en) 2007-11-14
WO2004026867A2 (en) 2004-04-01
CN1703414A (zh) 2005-11-30
MY133311A (en) 2007-11-30
DE60317529D1 (de) 2007-12-27
AR041291A1 (es) 2005-05-11
CA2499639C (en) 2011-11-08
JP2006507254A (ja) 2006-03-02
ATE378336T1 (de) 2007-11-15
US6992080B2 (en) 2006-01-31
IL167433A (en) 2011-03-31
WO2004026867A3 (en) 2004-08-05
JP4845379B2 (ja) 2011-12-28
KR20050052500A (ko) 2005-06-02
HK1071757A1 (en) 2005-07-29
ZA200502278B (en) 2006-05-31
US7452902B2 (en) 2008-11-18
CA2499639A1 (en) 2004-04-01
EP1539756A2 (en) 2005-06-15
US20060030555A1 (en) 2006-02-09
US20040097517A1 (en) 2004-05-20
TW200407322A (en) 2004-05-16
ES2293068T3 (es) 2008-03-16
MXPA05003058A (es) 2005-05-27
TWI351405B (en) 2011-11-01

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