CA2499639C - Imidazopyridines as cyclin dependent kinase inhibitors - Google Patents

Imidazopyridines as cyclin dependent kinase inhibitors Download PDF

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Publication number
CA2499639C
CA2499639C CA2499639A CA2499639A CA2499639C CA 2499639 C CA2499639 C CA 2499639C CA 2499639 A CA2499639 A CA 2499639A CA 2499639 A CA2499639 A CA 2499639A CA 2499639 C CA2499639 C CA 2499639C
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CA
Canada
Prior art keywords
group
aryl
alkyl
cancer
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2499639A
Other languages
English (en)
French (fr)
Other versions
CA2499639A1 (en
Inventor
Michael P. Dwyer
Timothy J. Guzi
Kamil Paruch
Ronald J. Doll
Kartik M. Keertikar
Viyyoor M. Girijavallabhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
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Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CA2499639A1 publication Critical patent/CA2499639A1/en
Application granted granted Critical
Publication of CA2499639C publication Critical patent/CA2499639C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2499639A 2002-09-19 2003-09-17 Imidazopyridines as cyclin dependent kinase inhibitors Expired - Fee Related CA2499639C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41206302P 2002-09-19 2002-09-19
US60/412,063 2002-09-19
PCT/US2003/029498 WO2004026867A2 (en) 2002-09-19 2003-09-17 Imidazopyridines as cyclin dependent kinase inhibitors

Publications (2)

Publication Number Publication Date
CA2499639A1 CA2499639A1 (en) 2004-04-01
CA2499639C true CA2499639C (en) 2011-11-08

Family

ID=32030794

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2499639A Expired - Fee Related CA2499639C (en) 2002-09-19 2003-09-17 Imidazopyridines as cyclin dependent kinase inhibitors

Country Status (18)

Country Link
US (2) US6992080B2 (https=)
EP (1) EP1539756B1 (https=)
JP (1) JP4845379B2 (https=)
KR (1) KR20050052500A (https=)
CN (1) CN100549011C (https=)
AR (1) AR041291A1 (https=)
AT (1) ATE378336T1 (https=)
AU (1) AU2003295332B2 (https=)
CA (1) CA2499639C (https=)
DE (1) DE60317529T2 (https=)
ES (1) ES2293068T3 (https=)
IL (1) IL167433A (https=)
MX (1) MXPA05003058A (https=)
MY (1) MY133311A (https=)
NZ (1) NZ538566A (https=)
TW (1) TWI351405B (https=)
WO (1) WO2004026867A2 (https=)
ZA (1) ZA200502278B (https=)

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Also Published As

Publication number Publication date
AU2003295332B2 (en) 2007-01-18
US6992080B2 (en) 2006-01-31
CN100549011C (zh) 2009-10-14
WO2004026867A3 (en) 2004-08-05
IL167433A (en) 2011-03-31
MXPA05003058A (es) 2005-05-27
TWI351405B (en) 2011-11-01
ATE378336T1 (de) 2007-11-15
WO2004026867A2 (en) 2004-04-01
TW200407322A (en) 2004-05-16
NZ538566A (en) 2008-02-29
KR20050052500A (ko) 2005-06-02
ZA200502278B (en) 2006-05-31
EP1539756B1 (en) 2007-11-14
US20040097517A1 (en) 2004-05-20
AR041291A1 (es) 2005-05-11
MY133311A (en) 2007-11-30
AU2003295332A1 (en) 2004-04-08
DE60317529T2 (de) 2008-09-25
JP2006507254A (ja) 2006-03-02
HK1071757A1 (en) 2005-07-29
US7452902B2 (en) 2008-11-18
JP4845379B2 (ja) 2011-12-28
ES2293068T3 (es) 2008-03-16
US20060030555A1 (en) 2006-02-09
EP1539756A2 (en) 2005-06-15
DE60317529D1 (de) 2007-12-27
CA2499639A1 (en) 2004-04-01
CN1703414A (zh) 2005-11-30

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Effective date: 20150917