DE60221510T2 - Das nk1 fragment des hepatocytwachstumfaktors/dispersionsfaktors (hgf/sf), varianten davon und deren verwendung - Google Patents
Das nk1 fragment des hepatocytwachstumfaktors/dispersionsfaktors (hgf/sf), varianten davon und deren verwendung Download PDFInfo
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- DE60221510T2 DE60221510T2 DE60221510T DE60221510T DE60221510T2 DE 60221510 T2 DE60221510 T2 DE 60221510T2 DE 60221510 T DE60221510 T DE 60221510T DE 60221510 T DE60221510 T DE 60221510T DE 60221510 T2 DE60221510 T2 DE 60221510T2
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- polypeptide
- heparin
- hgf
- polypeptide according
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Neurology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0110430.6A GB0110430D0 (en) | 2001-04-27 | 2001-04-27 | Protein variants and uses thereof |
| GB0110430 | 2001-04-27 | ||
| PCT/GB2002/001941 WO2002088354A1 (en) | 2001-04-27 | 2002-04-29 | The nk1 fragment of hepatocyte growth factor/scatter factor (hgf/sf) and variants thereof, and their use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60221510D1 DE60221510D1 (de) | 2007-09-13 |
| DE60221510T2 true DE60221510T2 (de) | 2008-04-17 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60221510T Expired - Lifetime DE60221510T2 (de) | 2001-04-27 | 2002-04-29 | Das nk1 fragment des hepatocytwachstumfaktors/dispersionsfaktors (hgf/sf), varianten davon und deren verwendung |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7179786B2 (enExample) |
| EP (1) | EP1381681B1 (enExample) |
| JP (2) | JP4637452B2 (enExample) |
| AT (1) | ATE368741T1 (enExample) |
| AU (1) | AU2002251337B2 (enExample) |
| CA (1) | CA2440775C (enExample) |
| DE (1) | DE60221510T2 (enExample) |
| DK (1) | DK1381681T3 (enExample) |
| ES (1) | ES2291460T3 (enExample) |
| GB (1) | GB0110430D0 (enExample) |
| WO (1) | WO2002088354A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| GB0110430D0 (en) * | 2001-04-27 | 2001-06-20 | Medical Res Council | Protein variants and uses thereof |
| US20050107296A1 (en) * | 2001-10-31 | 2005-05-19 | Institut Des Vaisseaux Et Du Sang | Isolated peptide of the hepatocyte growth factor and its variants, preparation method and therapeutic use as anti-angiogenic agents |
| AT412785B (de) * | 2003-12-04 | 2005-07-25 | Kungl Andreas J Dr | Gag-bindungsproteine |
| US7563570B2 (en) | 2004-10-29 | 2009-07-21 | Pangaea Biotech | Method of determining a chemotherapeutic regimen for non small cell lung cancer based on BRCA1 expression |
| US20090215686A1 (en) * | 2007-03-05 | 2009-08-27 | Huaqiang Eric Xu | Nk1-based polypeptides and related methods |
| AU2008323719B2 (en) * | 2007-11-09 | 2013-04-04 | New York Medical College | Methods for the repair and/or regeneration of damaged myocardium using variants of hepatocyte growth factor |
| WO2011103382A2 (en) * | 2010-02-22 | 2011-08-25 | The Brigham And Women's Hospital | Compositions and methods for inducing angiogenesis |
| WO2011116396A2 (en) * | 2010-03-19 | 2011-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists |
| AU2011326164B2 (en) | 2010-11-08 | 2016-05-05 | The Board Of Trustees Of The Leland Stanford Junior University | Fusion proteins comprising an engineered knottin peptide and uses thereof |
| WO2013037520A1 (en) | 2011-09-16 | 2013-03-21 | Glaxo Group Limited | Modified hgf-1k1 polypeptide |
| WO2013037521A1 (en) | 2011-09-16 | 2013-03-21 | Medical Research Council | Modified hgf-1k1 polypeptide |
| CA2973300C (en) * | 2015-01-21 | 2024-03-19 | Universite Des Sciences Et Technologies De Lille-Lille 1 | Met receptor agonist proteins |
| US10111966B2 (en) | 2016-06-17 | 2018-10-30 | Magenta Therapeutics, Inc. | Methods for the depletion of CD117+ cells |
| GB201611123D0 (en) * | 2016-06-27 | 2016-08-10 | Euremab Srl | Anti met antibodiesand uses thereof |
| US10576161B2 (en) | 2017-01-20 | 2020-03-03 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD137+ cells |
| IT201800000535A1 (it) | 2018-01-03 | 2019-07-03 | Procedimenti per la cura del cancro. | |
| CN109535243B (zh) * | 2019-01-07 | 2019-09-24 | 北京诺思兰德生物技术股份有限公司 | 人肝细胞生长因子突变体及其应用 |
| CN119613527A (zh) * | 2024-12-30 | 2025-03-14 | 江苏三仪生物工程有限公司 | 鸡肝细胞生长因子的截短突变体及其在防治肝脏相关疾病方面的用途 |
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| US5594115A (en) * | 1990-04-09 | 1997-01-14 | Pharmacia & Upjohn Company | Process of purifying recombinant proteins and compounds useful in such process |
| US6566098B1 (en) | 1990-09-14 | 2003-05-20 | The United States Of America As Represented By The Department Of Health And Human Services | DNA encoding truncated hepatocyte growth factor variants |
| PT642580E (pt) | 1992-05-18 | 2003-01-31 | Genentech Inc | Variantes de factor de crescimento dos hepatocitos |
| JP4006058B2 (ja) * | 1997-03-11 | 2007-11-14 | 第一三共株式会社 | 多臓器不全予防及び／又は治療剤 |
| GB0110430D0 (en) * | 2001-04-27 | 2001-06-20 | Medical Res Council | Protein variants and uses thereof |
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2001
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2002
- 2002-04-29 US US10/475,616 patent/US7179786B2/en not_active Expired - Fee Related
- 2002-04-29 ES ES02720271T patent/ES2291460T3/es not_active Expired - Lifetime
- 2002-04-29 AU AU2002251337A patent/AU2002251337B2/en not_active Ceased
- 2002-04-29 WO PCT/GB2002/001941 patent/WO2002088354A1/en not_active Ceased
- 2002-04-29 JP JP2002585635A patent/JP4637452B2/ja not_active Expired - Fee Related
- 2002-04-29 DK DK02720271T patent/DK1381681T3/da active
- 2002-04-29 AT AT02720271T patent/ATE368741T1/de not_active IP Right Cessation
- 2002-04-29 DE DE60221510T patent/DE60221510T2/de not_active Expired - Lifetime
- 2002-04-29 EP EP02720271A patent/EP1381681B1/en not_active Expired - Lifetime
- 2002-04-29 CA CA2440775A patent/CA2440775C/en not_active Expired - Fee Related
-
2007
- 2007-01-26 US US11/627,761 patent/US7795214B2/en not_active Expired - Fee Related
-
2010
- 2010-08-17 US US12/858,189 patent/US8232258B2/en not_active Expired - Fee Related
- 2010-09-17 JP JP2010208693A patent/JP2011045370A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA2440775A1 (en) | 2002-11-07 |
| US20040236073A1 (en) | 2004-11-25 |
| CA2440775C (en) | 2013-02-26 |
| US8232258B2 (en) | 2012-07-31 |
| DK1381681T3 (da) | 2007-10-29 |
| US7179786B2 (en) | 2007-02-20 |
| DE60221510D1 (de) | 2007-09-13 |
| ATE368741T1 (de) | 2007-08-15 |
| EP1381681A1 (en) | 2004-01-21 |
| JP2011045370A (ja) | 2011-03-10 |
| GB0110430D0 (en) | 2001-06-20 |
| JP2004532032A (ja) | 2004-10-21 |
| US20110021612A1 (en) | 2011-01-27 |
| AU2002251337B2 (en) | 2007-08-02 |
| JP4637452B2 (ja) | 2011-02-23 |
| US20080167224A1 (en) | 2008-07-10 |
| ES2291460T3 (es) | 2008-03-01 |
| US7795214B2 (en) | 2010-09-14 |
| EP1381681B1 (en) | 2007-08-01 |
| WO2002088354A1 (en) | 2002-11-07 |
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| Date | Code | Title | Description |
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| 8381 | Inventor (new situation) |
Inventor name: GHERARDI, ERMANNO, CAMBRIDGE CAMBRIDGESHIRE CB, GB Inventor name: LIETHA, DANIEL, CAMBRIDGE, CAMBRIDGESHIRE CB2 , GB Inventor name: BLUNDELL, THOMAS LEON, CAMBRIDGE, CAMBRIDGESHI, GB Inventor name: CHIRGADZE, DIMITRY YURIEVICH, CAMBRIDGE, CAMBR, GB |
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| 8364 | No opposition during term of opposition |