JP4637452B2 - 肝細胞増殖因子／細胞分散因子（ｈｇｆ／ｓｆ）のｎｋ１断片およびそれらの変異体、ならびにそれらの使用 - Google Patents
肝細胞増殖因子／細胞分散因子（ｈｇｆ／ｓｆ）のｎｋ１断片およびそれらの変異体、ならびにそれらの使用 Download PDFInfo
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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| Application Number | Priority Date | Filing Date | Title |
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| GBGB0110430.6A GB0110430D0 (en) | 2001-04-27 | 2001-04-27 | Protein variants and uses thereof |
| PCT/GB2002/001941 WO2002088354A1 (en) | 2001-04-27 | 2002-04-29 | The nk1 fragment of hepatocyte growth factor/scatter factor (hgf/sf) and variants thereof, and their use |
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| JP2010208693A Division JP2011045370A (ja) | 2001-04-27 | 2010-09-17 | 肝細胞増殖因子／細胞分散因子（ｈｇｆ／ｓｆ）のｎｋ１断片およびそれらの変異体、ならびにそれらの使用 |
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| JP2004532032A JP2004532032A (ja) | 2004-10-21 |
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| JP2010208693A Pending JP2011045370A (ja) | 2001-04-27 | 2010-09-17 | 肝細胞増殖因子／細胞分散因子（ｈｇｆ／ｓｆ）のｎｋ１断片およびそれらの変異体、ならびにそれらの使用 |
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| JP2010208693A Pending JP2011045370A (ja) | 2001-04-27 | 2010-09-17 | 肝細胞増殖因子／細胞分散因子（ｈｇｆ／ｓｆ）のｎｋ１断片およびそれらの変異体、ならびにそれらの使用 |
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| EP (1) | EP1381681B1 (enExample) |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011045370A (ja) * | 2001-04-27 | 2011-03-10 | Medical Research Council | 肝細胞増殖因子／細胞分散因子（ｈｇｆ／ｓｆ）のｎｋ１断片およびそれらの変異体、ならびにそれらの使用 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050107296A1 (en) * | 2001-10-31 | 2005-05-19 | Institut Des Vaisseaux Et Du Sang | Isolated peptide of the hepatocyte growth factor and its variants, preparation method and therapeutic use as anti-angiogenic agents |
| AT412785B (de) * | 2003-12-04 | 2005-07-25 | Kungl Andreas J Dr | Gag-bindungsproteine |
| US7563570B2 (en) | 2004-10-29 | 2009-07-21 | Pangaea Biotech | Method of determining a chemotherapeutic regimen for non small cell lung cancer based on BRCA1 expression |
| US20090215686A1 (en) * | 2007-03-05 | 2009-08-27 | Huaqiang Eric Xu | Nk1-based polypeptides and related methods |
| AU2008323719B2 (en) * | 2007-11-09 | 2013-04-04 | New York Medical College | Methods for the repair and/or regeneration of damaged myocardium using variants of hepatocyte growth factor |
| WO2011103382A2 (en) * | 2010-02-22 | 2011-08-25 | The Brigham And Women's Hospital | Compositions and methods for inducing angiogenesis |
| WO2011116396A2 (en) * | 2010-03-19 | 2011-09-22 | The Board Of Trustees Of The Leland Stanford Junior University | Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists |
| AU2011326164B2 (en) | 2010-11-08 | 2016-05-05 | The Board Of Trustees Of The Leland Stanford Junior University | Fusion proteins comprising an engineered knottin peptide and uses thereof |
| WO2013037520A1 (en) | 2011-09-16 | 2013-03-21 | Glaxo Group Limited | Modified hgf-1k1 polypeptide |
| WO2013037521A1 (en) | 2011-09-16 | 2013-03-21 | Medical Research Council | Modified hgf-1k1 polypeptide |
| CA2973300C (en) * | 2015-01-21 | 2024-03-19 | Universite Des Sciences Et Technologies De Lille-Lille 1 | Met receptor agonist proteins |
| US10111966B2 (en) | 2016-06-17 | 2018-10-30 | Magenta Therapeutics, Inc. | Methods for the depletion of CD117+ cells |
| GB201611123D0 (en) * | 2016-06-27 | 2016-08-10 | Euremab Srl | Anti met antibodiesand uses thereof |
| US10576161B2 (en) | 2017-01-20 | 2020-03-03 | Magenta Therapeutics, Inc. | Compositions and methods for the depletion of CD137+ cells |
| IT201800000535A1 (it) | 2018-01-03 | 2019-07-03 | Procedimenti per la cura del cancro. | |
| CN109535243B (zh) * | 2019-01-07 | 2019-09-24 | 北京诺思兰德生物技术股份有限公司 | 人肝细胞生长因子突变体及其应用 |
| CN119613527A (zh) * | 2024-12-30 | 2025-03-14 | 江苏三仪生物工程有限公司 | 鸡肝细胞生长因子的截短突变体及其在防治肝脏相关疾病方面的用途 |
Family Cites Families (5)
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|---|---|---|---|---|
| US5594115A (en) * | 1990-04-09 | 1997-01-14 | Pharmacia & Upjohn Company | Process of purifying recombinant proteins and compounds useful in such process |
| US6566098B1 (en) | 1990-09-14 | 2003-05-20 | The United States Of America As Represented By The Department Of Health And Human Services | DNA encoding truncated hepatocyte growth factor variants |
| PT642580E (pt) | 1992-05-18 | 2003-01-31 | Genentech Inc | Variantes de factor de crescimento dos hepatocitos |
| JP4006058B2 (ja) * | 1997-03-11 | 2007-11-14 | 第一三共株式会社 | 多臓器不全予防及び／又は治療剤 |
| GB0110430D0 (en) * | 2001-04-27 | 2001-06-20 | Medical Res Council | Protein variants and uses thereof |
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2002
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011045370A (ja) * | 2001-04-27 | 2011-03-10 | Medical Research Council | 肝細胞増殖因子／細胞分散因子（ｈｇｆ／ｓｆ）のｎｋ１断片およびそれらの変異体、ならびにそれらの使用 |
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| CA2440775A1 (en) | 2002-11-07 |
| US20040236073A1 (en) | 2004-11-25 |
| CA2440775C (en) | 2013-02-26 |
| US8232258B2 (en) | 2012-07-31 |
| DE60221510T2 (de) | 2008-04-17 |
| DK1381681T3 (da) | 2007-10-29 |
| US7179786B2 (en) | 2007-02-20 |
| DE60221510D1 (de) | 2007-09-13 |
| ATE368741T1 (de) | 2007-08-15 |
| EP1381681A1 (en) | 2004-01-21 |
| JP2011045370A (ja) | 2011-03-10 |
| GB0110430D0 (en) | 2001-06-20 |
| JP2004532032A (ja) | 2004-10-21 |
| US20110021612A1 (en) | 2011-01-27 |
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| ES2291460T3 (es) | 2008-03-01 |
| US7795214B2 (en) | 2010-09-14 |
| EP1381681B1 (en) | 2007-08-01 |
| WO2002088354A1 (en) | 2002-11-07 |
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