AU2002251337B2 - The NK1 fragment of hepatocyte growth factors/scatter factor (HGF/SF) and variants thereof, and their use - Google Patents

The NK1 fragment of hepatocyte growth factors/scatter factor (HGF/SF) and variants thereof, and their use Download PDF

Info

Publication number
AU2002251337B2
AU2002251337B2 AU2002251337A AU2002251337A AU2002251337B2 AU 2002251337 B2 AU2002251337 B2 AU 2002251337B2 AU 2002251337 A AU2002251337 A AU 2002251337A AU 2002251337 A AU2002251337 A AU 2002251337A AU 2002251337 B2 AU2002251337 B2 AU 2002251337B2
Authority
AU
Australia
Prior art keywords
polypeptide
heparin
treatment
hgf
polypeptide according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002251337A
Other languages
English (en)
Other versions
AU2002251337A1 (en
Inventor
Thomas Leon Blundell
Dimitry Yurievich Chirgadze
Ermanno Gherardi
Daniel Lietha
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medical Research Council
Cambridge University Technical Services Ltd CUTS
Original Assignee
Medical Research Council
Cambridge University Technical Services Ltd CUTS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medical Research Council, Cambridge University Technical Services Ltd CUTS filed Critical Medical Research Council
Publication of AU2002251337A1 publication Critical patent/AU2002251337A1/en
Assigned to MEDICAL RESEARCH COUNCIL, CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED reassignment MEDICAL RESEARCH COUNCIL Amend patent request/document other than specification (104) Assignors: Refer to Publication History
Application granted granted Critical
Publication of AU2002251337B2 publication Critical patent/AU2002251337B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
AU2002251337A 2001-04-27 2002-04-29 The NK1 fragment of hepatocyte growth factors/scatter factor (HGF/SF) and variants thereof, and their use Ceased AU2002251337B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0110430.6 2001-04-27
GBGB0110430.6A GB0110430D0 (en) 2001-04-27 2001-04-27 Protein variants and uses thereof
PCT/GB2002/001941 WO2002088354A1 (en) 2001-04-27 2002-04-29 The nk1 fragment of hepatocyte growth factor/scatter factor (hgf/sf) and variants thereof, and their use

Publications (2)

Publication Number Publication Date
AU2002251337A1 AU2002251337A1 (en) 2003-04-17
AU2002251337B2 true AU2002251337B2 (en) 2007-08-02

Family

ID=9913640

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002251337A Ceased AU2002251337B2 (en) 2001-04-27 2002-04-29 The NK1 fragment of hepatocyte growth factors/scatter factor (HGF/SF) and variants thereof, and their use

Country Status (11)

Country Link
US (3) US7179786B2 (enExample)
EP (1) EP1381681B1 (enExample)
JP (2) JP4637452B2 (enExample)
AT (1) ATE368741T1 (enExample)
AU (1) AU2002251337B2 (enExample)
CA (1) CA2440775C (enExample)
DE (1) DE60221510T2 (enExample)
DK (1) DK1381681T3 (enExample)
ES (1) ES2291460T3 (enExample)
GB (1) GB0110430D0 (enExample)
WO (1) WO2002088354A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113383012A (zh) * 2019-01-07 2021-09-10 北京诺思兰德生物技术股份有限公司 人肝细胞生长因子突变体及其应用

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0110430D0 (en) * 2001-04-27 2001-06-20 Medical Res Council Protein variants and uses thereof
US20050107296A1 (en) * 2001-10-31 2005-05-19 Institut Des Vaisseaux Et Du Sang Isolated peptide of the hepatocyte growth factor and its variants, preparation method and therapeutic use as anti-angiogenic agents
AT412785B (de) * 2003-12-04 2005-07-25 Kungl Andreas J Dr Gag-bindungsproteine
US7563570B2 (en) 2004-10-29 2009-07-21 Pangaea Biotech Method of determining a chemotherapeutic regimen for non small cell lung cancer based on BRCA1 expression
US20090215686A1 (en) * 2007-03-05 2009-08-27 Huaqiang Eric Xu Nk1-based polypeptides and related methods
AU2008323719B2 (en) * 2007-11-09 2013-04-04 New York Medical College Methods for the repair and/or regeneration of damaged myocardium using variants of hepatocyte growth factor
CN103037892A (zh) * 2010-02-22 2013-04-10 布里格姆妇女医院 诱导血管生成的组合物和方法
US9556248B2 (en) * 2010-03-19 2017-01-31 The Board Of Trustees Of The Leland Stanford Junior University Hepatocyte growth factor fragments that function as potent met receptor agonists and antagonists
CA2817197C (en) 2010-11-08 2020-08-04 The Board Of Trustees Of The Leland Stanford Junior University Fusion proteins comprising an engineered knottin peptide and uses thereof
WO2013037520A1 (en) 2011-09-16 2013-03-21 Glaxo Group Limited Modified hgf-1k1 polypeptide
WO2013037521A1 (en) 2011-09-16 2013-03-21 Medical Research Council Modified hgf-1k1 polypeptide
EP3247719B1 (en) * 2015-01-21 2019-09-25 Université de Lille Met receptor agonist proteins
US10111966B2 (en) 2016-06-17 2018-10-30 Magenta Therapeutics, Inc. Methods for the depletion of CD117+ cells
GB201611123D0 (en) 2016-06-27 2016-08-10 Euremab Srl Anti met antibodiesand uses thereof
SG11201906319XA (en) 2017-01-20 2019-08-27 Magenta Therapeutics Inc Compositions and methods for the depletion of cd137+ cells
IT201800000535A1 (it) 2018-01-03 2019-07-03 Procedimenti per la cura del cancro.
JP2022513178A (ja) 2018-10-09 2022-02-07 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 受容体アンタゴニストとしての操作された線維芽細胞増殖因子多様体
CN119613527B (zh) * 2024-12-30 2026-02-06 江苏三仪生物工程有限公司 鸡肝细胞生长因子的截短突变体及其在防治肝脏相关疾病方面的用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040914A1 (en) * 1995-06-07 1996-12-19 Chan Andrew M L Truncated hepatocyte growth factor variants

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594115A (en) * 1990-04-09 1997-01-14 Pharmacia & Upjohn Company Process of purifying recombinant proteins and compounds useful in such process
DK0642580T3 (da) 1992-05-18 2002-12-23 Genentech Inc Hepactocytvækstfaktorvarianter
JP4006058B2 (ja) * 1997-03-11 2007-11-14 第一三共株式会社 多臓器不全予防及び／又は治療剤
GB0110430D0 (en) * 2001-04-27 2001-06-20 Medical Res Council Protein variants and uses thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040914A1 (en) * 1995-06-07 1996-12-19 Chan Andrew M L Truncated hepatocyte growth factor variants

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Molecular and Cellular Biology, March 1998, 18(3): 1275-83 *
The EMBO Journal, Oct 2001, 20(20): 5543-55 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113383012A (zh) * 2019-01-07 2021-09-10 北京诺思兰德生物技术股份有限公司 人肝细胞生长因子突变体及其应用

Also Published As

Publication number Publication date
US20110021612A1 (en) 2011-01-27
US20040236073A1 (en) 2004-11-25
ES2291460T3 (es) 2008-03-01
JP2004532032A (ja) 2004-10-21
EP1381681B1 (en) 2007-08-01
GB0110430D0 (en) 2001-06-20
JP2011045370A (ja) 2011-03-10
CA2440775C (en) 2013-02-26
WO2002088354A1 (en) 2002-11-07
DE60221510D1 (de) 2007-09-13
US8232258B2 (en) 2012-07-31
DK1381681T3 (da) 2007-10-29
ATE368741T1 (de) 2007-08-15
US7795214B2 (en) 2010-09-14
US7179786B2 (en) 2007-02-20
DE60221510T2 (de) 2008-04-17
CA2440775A1 (en) 2002-11-07
JP4637452B2 (ja) 2011-02-23
EP1381681A1 (en) 2004-01-21
US20080167224A1 (en) 2008-07-10

Similar Documents

Publication Publication Date Title
US7795214B2 (en) Variants of the NK1 fragment of hepatocyte growth factor/scatter factor (HGF/SF) and their use
AU2002251337A1 (en) The NK1 fragment of hepatocyte growth factors/scatter factor (HGF/SF) and variants thereof, and their use
US7671180B2 (en) Fibroblast growth factor-like polypeptides and variants thereof
JPH06113854A (ja) 血管内皮細胞増殖因子ｃサブユニット
SG193483A1 (en) Variants of human gdnf
EP0981620B1 (en) Hgf polypeptides and their use in therapy
AU2008201780B2 (en) Fibroblast growth factor-like polypeptides
AU2004242465B2 (en) Fibroblast Growth Factor-Like Polypeptides
Hartmann et al. activity in vivo

Legal Events

Date Code Title Description
DA3 Amendments made section 104

Free format text: THE NATURE OF THE AMENDMENT IS: ADD THE CO-APPLICANT CAMBRIDGE UNIVERSITY TECHNICAL SERVICES LIMITED.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired