DE60213990T2 - Lösungen für die lagerung und perfusion von organen für transplantationen - Google Patents

Lösungen für die lagerung und perfusion von organen für transplantationen Download PDF

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Publication number
DE60213990T2
DE60213990T2 DE60213990T DE60213990T DE60213990T2 DE 60213990 T2 DE60213990 T2 DE 60213990T2 DE 60213990 T DE60213990 T DE 60213990T DE 60213990 T DE60213990 T DE 60213990T DE 60213990 T2 DE60213990 T2 DE 60213990T2
Authority
DE
Germany
Prior art keywords
carnitine
acid
solution
storage
perfusion
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60213990T
Other languages
German (de)
English (en)
Other versions
DE60213990D1 (de
Inventor
Arduino Arduini
Tommaso Aureli
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of DE60213990D1 publication Critical patent/DE60213990D1/de
Application granted granted Critical
Publication of DE60213990T2 publication Critical patent/DE60213990T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/12—Chemical aspects of preservation
    • A01N1/122—Preservation or perfusion media
    • A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60213990T 2001-06-14 2002-06-13 Lösungen für die lagerung und perfusion von organen für transplantationen Expired - Lifetime DE60213990T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT2001RM000337A ITRM20010337A1 (it) 2001-06-14 2001-06-14 Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati.
ITRM20010337 2001-06-14
PCT/IT2002/000391 WO2002102149A1 (en) 2001-06-14 2002-06-13 Solution for the storage and perfusion of organs awaiting transplantation

Publications (2)

Publication Number Publication Date
DE60213990D1 DE60213990D1 (de) 2006-09-28
DE60213990T2 true DE60213990T2 (de) 2007-03-15

Family

ID=11455594

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60213990T Expired - Lifetime DE60213990T2 (de) 2001-06-14 2002-06-13 Lösungen für die lagerung und perfusion von organen für transplantationen

Country Status (15)

Country Link
US (3) US7422844B2 (enExample)
EP (1) EP1401270B1 (enExample)
JP (1) JP4268036B2 (enExample)
KR (1) KR100844191B1 (enExample)
AT (1) ATE336166T1 (enExample)
CA (1) CA2450623C (enExample)
CY (1) CY1106202T1 (enExample)
DE (1) DE60213990T2 (enExample)
DK (1) DK1401270T3 (enExample)
ES (1) ES2271290T3 (enExample)
IT (1) ITRM20010337A1 (enExample)
MX (1) MXPA03011461A (enExample)
PL (1) PL206312B1 (enExample)
PT (1) PT1401270E (enExample)
WO (1) WO2002102149A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20010337A1 (it) * 2001-06-14 2002-12-16 Sigma Tau Ind Farmaceuti Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati.
JP2005095152A (ja) * 2003-08-29 2005-04-14 Japan Tissue Engineering:Kk 培養組織の保存方法
WO2006026304A1 (en) * 2004-08-25 2006-03-09 Ivax Corporation Cardioprotective formulations and uses thereof
TWI388318B (zh) * 2005-03-10 2013-03-11 西格瑪 陶製藥廠 具有改良之生物相容性的含有肉毒鹼之腹膜透析溶液
JP2006347935A (ja) * 2005-06-15 2006-12-28 Masanori Ogata 炎症性サイトカインの産生が関与する疾患の予防及び／又は治療のための医薬
GB0612877D0 (en) * 2006-06-29 2006-08-09 Univ Edinburgh Organ preservation solution
EP2543249B1 (en) 2007-02-17 2018-05-23 President and Fellows of Harvard College Compositions and method for tissue preservation
CN102088968A (zh) 2008-02-15 2011-06-08 哈佛学院董事会 血液替代溶液
JP5201218B2 (ja) * 2009-06-15 2013-06-05 トヨタ自動車株式会社 無細胞タンパク質合成溶液、無細胞タンパク質合成キット及びタンパク質合成方法
RU2707532C1 (ru) * 2018-10-11 2019-11-27 Российская Федерация, от имени которой выступает ФОНД ПЕРСПЕКТИВНЫХ ИССЛЕДОВАНИЙ Способ повышения безопасности и эффективности хранения и транспортировки трансплантируемого органа под давлением консервирующей газовой смеси и устройство на его основе
CN109511650B (zh) * 2018-11-21 2021-06-15 嘉兴莱普晟医疗科技有限公司 一种可以扩大供肝来源的常温机械灌注液
IT201900007446A1 (it) * 2019-05-29 2020-11-29 Giuseppe Castellano Composizione comprendente citrato e carnitina in grado di attivare la produzione della proteina klotho
WO2021183653A1 (en) * 2020-03-10 2021-09-16 University Of Florida Research Foundation, Incorporated Compositions for extending viable preservation and shelf-life of organs and tissues

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5498427A (en) 1990-11-20 1996-03-12 Pasteur Merieux Serums Et Vaccines Solutions for the perfusion, preservation and reperfusion of organs
IT1261695B (it) * 1993-06-02 1996-05-29 Sigma Tau Ind Farmaceuti Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono.
WO1996018293A1 (en) * 1994-12-12 1996-06-20 Charlotte-Mecklenburg Hospital Authority Organ transplant solutions and method for transplanting an organ
US5707971A (en) * 1995-06-07 1998-01-13 Life Resuscitation Technologies, Inc. Modulation of glycolytic ATP production
US5834178C1 (en) * 1997-07-09 2002-04-23 Univ Wayne State Flush-storage solution for donor organs
CA2352485A1 (en) * 1998-11-26 2000-06-02 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Use of fumarate salt of l-carnitine or its alkanoyl derivatives in ischaemia
HUP0203441A3 (en) 1999-10-11 2004-01-28 Sigma Tau Ind Farmaceuti Use of l-carnitine and its alkanoyl derivatives as osmotic agents and solutions for medical use
ITRM20010337A1 (it) 2001-06-14 2002-12-16 Sigma Tau Ind Farmaceuti Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati.

Also Published As

Publication number Publication date
KR100844191B1 (ko) 2008-07-04
CY1106202T1 (el) 2011-06-08
ES2271290T3 (es) 2007-04-16
JP2004529205A (ja) 2004-09-24
JP4268036B2 (ja) 2009-05-27
WO2002102149A1 (en) 2002-12-27
CA2450623C (en) 2011-05-10
US8007993B2 (en) 2011-08-30
DE60213990D1 (de) 2006-09-28
ITRM20010337A1 (it) 2002-12-16
KR20040010712A (ko) 2004-01-31
EP1401270A1 (en) 2004-03-31
US20080199844A1 (en) 2008-08-21
US7989158B2 (en) 2011-08-02
ATE336166T1 (de) 2006-09-15
DK1401270T3 (da) 2006-12-27
US20080166695A1 (en) 2008-07-10
US20040156990A1 (en) 2004-08-12
PL206312B1 (pl) 2010-07-30
CA2450623A1 (en) 2002-12-27
PL367837A1 (en) 2005-03-07
US7422844B2 (en) 2008-09-09
EP1401270B1 (en) 2006-08-16
MXPA03011461A (es) 2004-07-01
ITRM20010337A0 (it) 2001-06-14
PT1401270E (pt) 2006-10-31

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