ITRM20010337A1 - Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. - Google Patents
Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati.Info
- Publication number
- ITRM20010337A1 ITRM20010337A1 IT2001RM000337A ITRM20010337A ITRM20010337A1 IT RM20010337 A1 ITRM20010337 A1 IT RM20010337A1 IT 2001RM000337 A IT2001RM000337 A IT 2001RM000337A IT RM20010337 A ITRM20010337 A IT RM20010337A IT RM20010337 A1 ITRM20010337 A1 IT RM20010337A1
- Authority
- IT
- Italy
- Prior art keywords
- solution
- physiologically acceptable
- perfection
- transplanted
- conservation
- Prior art date
Links
- 210000000056 organ Anatomy 0.000 title abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 2
- 239000010452 phosphate Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- -1 alkanoyl L-carnitine Chemical compound 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/126—Physiologically active agents, e.g. antioxidants or nutrients
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000337A ITRM20010337A1 (it) | 2001-06-14 | 2001-06-14 | Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. |
| PT02745791T PT1401270E (pt) | 2001-06-14 | 2002-06-13 | Solucao para o armazenamento e perfusao de orgaos que aguardam transplantacao |
| EP02745791A EP1401270B1 (en) | 2001-06-14 | 2002-06-13 | Solution for the storage and perfusion of organs awaiting transplantation |
| JP2003504747A JP4268036B2 (ja) | 2001-06-14 | 2002-06-13 | 移植前の臓器の貯蔵および灌流用溶液 |
| CA2450623A CA2450623C (en) | 2001-06-14 | 2002-06-13 | Solution for the storage and perfusion of organs awaiting transplantation |
| DK02745791T DK1401270T3 (da) | 2001-06-14 | 2002-06-13 | Oplösning til opbevaringen og perfusionen af organer, der afventer transplantation |
| KR1020037016372A KR100844191B1 (ko) | 2001-06-14 | 2002-06-13 | 이식 대기중인 기관의 저장 및 관류를 위한 용액 |
| DE60213990T DE60213990T2 (de) | 2001-06-14 | 2002-06-13 | Lösungen für die lagerung und perfusion von organen für transplantationen |
| US10/480,824 US7422844B2 (en) | 2001-06-14 | 2002-06-13 | Solution for the storage and perfusion of organs awaiting transplantation |
| AT02745791T ATE336166T1 (de) | 2001-06-14 | 2002-06-13 | Lösungen für die lagerung und perfusion von organen für transplantationen |
| PL367837A PL206312B1 (pl) | 2001-06-14 | 2002-06-13 | Roztwór do utrzymywania i perfuzji organów przeznaczonych do transplantacji |
| ES02745791T ES2271290T3 (es) | 2001-06-14 | 2002-06-13 | Solucion para el almacenamiento y perfusion de organos en espera de ser transplantados. |
| MXPA03011461A MXPA03011461A (es) | 2001-06-14 | 2002-06-13 | Solucion para almacenamiento y perfusion d eroganos que esperan ser trasplantados. |
| PCT/IT2002/000391 WO2002102149A1 (en) | 2001-06-14 | 2002-06-13 | Solution for the storage and perfusion of organs awaiting transplantation |
| CY20061101484T CY1106202T1 (el) | 2001-06-14 | 2006-10-16 | Διαλυμα για την αποθηκευση και διαποτιση οργανων αναμενοντας μεταμοσχευση |
| US12/010,931 US8007993B2 (en) | 2001-06-14 | 2008-01-31 | Method for storage and perfusion of organs using a solution comprising L-carnitine and isovaleryl L-carnitine |
| US12/068,055 US7989158B2 (en) | 2001-06-14 | 2008-02-01 | Solution containing carnitine for the storage and perfusion of organs awaiting transplantation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2001RM000337A ITRM20010337A1 (it) | 2001-06-14 | 2001-06-14 | Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ITRM20010337A0 ITRM20010337A0 (it) | 2001-06-14 |
| ITRM20010337A1 true ITRM20010337A1 (it) | 2002-12-16 |
Family
ID=11455594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT2001RM000337A ITRM20010337A1 (it) | 2001-06-14 | 2001-06-14 | Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7422844B2 (enExample) |
| EP (1) | EP1401270B1 (enExample) |
| JP (1) | JP4268036B2 (enExample) |
| KR (1) | KR100844191B1 (enExample) |
| AT (1) | ATE336166T1 (enExample) |
| CA (1) | CA2450623C (enExample) |
| CY (1) | CY1106202T1 (enExample) |
| DE (1) | DE60213990T2 (enExample) |
| DK (1) | DK1401270T3 (enExample) |
| ES (1) | ES2271290T3 (enExample) |
| IT (1) | ITRM20010337A1 (enExample) |
| MX (1) | MXPA03011461A (enExample) |
| PL (1) | PL206312B1 (enExample) |
| PT (1) | PT1401270E (enExample) |
| WO (1) | WO2002102149A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20010337A1 (it) * | 2001-06-14 | 2002-12-16 | Sigma Tau Ind Farmaceuti | Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. |
| JP2005095152A (ja) * | 2003-08-29 | 2005-04-14 | Japan Tissue Engineering:Kk | 培養組織の保存方法 |
| WO2006026304A1 (en) * | 2004-08-25 | 2006-03-09 | Ivax Corporation | Cardioprotective formulations and uses thereof |
| TWI388318B (zh) * | 2005-03-10 | 2013-03-11 | Sigma Tau Ind Farmaceuti | 具有改良之生物相容性的含有肉毒鹼之腹膜透析溶液 |
| JP2006347935A (ja) * | 2005-06-15 | 2006-12-28 | Masanori Ogata | 炎症性サイトカインの産生が関与する疾患の予防及び／又は治療のための医薬 |
| GB0612877D0 (en) * | 2006-06-29 | 2006-08-09 | Univ Edinburgh | Organ preservation solution |
| BRPI0807918A2 (pt) * | 2007-02-17 | 2017-05-16 | Harvard College | composições e método para preservação de tecido |
| JP2011512350A (ja) | 2008-02-15 | 2011-04-21 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 血液代用溶液 |
| WO2010147111A1 (ja) * | 2009-06-15 | 2010-12-23 | トヨタ自動車株式会社 | 無細胞タンパク質合成溶液、無細胞タンパク質合成キット及びタンパク質合成方法 |
| RU2707532C1 (ru) * | 2018-10-11 | 2019-11-27 | Российская Федерация, от имени которой выступает ФОНД ПЕРСПЕКТИВНЫХ ИССЛЕДОВАНИЙ | Способ повышения безопасности и эффективности хранения и транспортировки трансплантируемого органа под давлением консервирующей газовой смеси и устройство на его основе |
| CN109511650B (zh) * | 2018-11-21 | 2021-06-15 | 嘉兴莱普晟医疗科技有限公司 | 一种可以扩大供肝来源的常温机械灌注液 |
| IT201900007446A1 (it) * | 2019-05-29 | 2020-11-29 | Giuseppe Castellano | Composizione comprendente citrato e carnitina in grado di attivare la produzione della proteina klotho |
| US20230087020A1 (en) * | 2020-03-10 | 2023-03-23 | University Of Florida Research Foundation, Incorporated | Composition for extending viable preservation and shelf-life of organs and tissues |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5498427A (en) | 1990-11-20 | 1996-03-12 | Pasteur Merieux Serums Et Vaccines | Solutions for the perfusion, preservation and reperfusion of organs |
| IT1261695B (it) * | 1993-06-02 | 1996-05-29 | Sigma Tau Ind Farmaceuti | Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono. |
| AU4420396A (en) * | 1994-12-12 | 1996-07-03 | Charlotte-Mecklenburg Hospital Authority | Organ transplant solutions and method for transplanting an organ |
| US5707971A (en) | 1995-06-07 | 1998-01-13 | Life Resuscitation Technologies, Inc. | Modulation of glycolytic ATP production |
| US5834178C1 (en) * | 1997-07-09 | 2002-04-23 | Univ Wayne State | Flush-storage solution for donor organs |
| WO2000030637A1 (en) | 1998-11-26 | 2000-06-02 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of fumarate salt of l-carnitine or its alkanoyl derivatives in ischaemia |
| AU1073400A (en) | 1999-10-11 | 2001-04-23 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of l-carnitine and its alkanoyl derivatives as osmotic agents in solutions for medical use |
| ITRM20010337A1 (it) | 2001-06-14 | 2002-12-16 | Sigma Tau Ind Farmaceuti | Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. |
-
2001
- 2001-06-14 IT IT2001RM000337A patent/ITRM20010337A1/it unknown
-
2002
- 2002-06-13 WO PCT/IT2002/000391 patent/WO2002102149A1/en not_active Ceased
- 2002-06-13 CA CA2450623A patent/CA2450623C/en not_active Expired - Fee Related
- 2002-06-13 ES ES02745791T patent/ES2271290T3/es not_active Expired - Lifetime
- 2002-06-13 US US10/480,824 patent/US7422844B2/en not_active Expired - Fee Related
- 2002-06-13 DK DK02745791T patent/DK1401270T3/da active
- 2002-06-13 EP EP02745791A patent/EP1401270B1/en not_active Expired - Lifetime
- 2002-06-13 PT PT02745791T patent/PT1401270E/pt unknown
- 2002-06-13 MX MXPA03011461A patent/MXPA03011461A/es active IP Right Grant
- 2002-06-13 PL PL367837A patent/PL206312B1/pl not_active IP Right Cessation
- 2002-06-13 AT AT02745791T patent/ATE336166T1/de active
- 2002-06-13 JP JP2003504747A patent/JP4268036B2/ja not_active Expired - Fee Related
- 2002-06-13 KR KR1020037016372A patent/KR100844191B1/ko not_active Expired - Fee Related
- 2002-06-13 DE DE60213990T patent/DE60213990T2/de not_active Expired - Lifetime
-
2006
- 2006-10-16 CY CY20061101484T patent/CY1106202T1/el unknown
-
2008
- 2008-01-31 US US12/010,931 patent/US8007993B2/en not_active Expired - Fee Related
- 2008-02-01 US US12/068,055 patent/US7989158B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ATE336166T1 (de) | 2006-09-15 |
| US7989158B2 (en) | 2011-08-02 |
| PL206312B1 (pl) | 2010-07-30 |
| US8007993B2 (en) | 2011-08-30 |
| EP1401270A1 (en) | 2004-03-31 |
| US20040156990A1 (en) | 2004-08-12 |
| WO2002102149A1 (en) | 2002-12-27 |
| KR100844191B1 (ko) | 2008-07-04 |
| CY1106202T1 (el) | 2011-06-08 |
| ITRM20010337A0 (it) | 2001-06-14 |
| DK1401270T3 (da) | 2006-12-27 |
| DE60213990T2 (de) | 2007-03-15 |
| JP2004529205A (ja) | 2004-09-24 |
| JP4268036B2 (ja) | 2009-05-27 |
| DE60213990D1 (de) | 2006-09-28 |
| PT1401270E (pt) | 2006-10-31 |
| US7422844B2 (en) | 2008-09-09 |
| US20080166695A1 (en) | 2008-07-10 |
| KR20040010712A (ko) | 2004-01-31 |
| CA2450623C (en) | 2011-05-10 |
| EP1401270B1 (en) | 2006-08-16 |
| MXPA03011461A (es) | 2004-07-01 |
| CA2450623A1 (en) | 2002-12-27 |
| ES2271290T3 (es) | 2007-04-16 |
| US20080199844A1 (en) | 2008-08-21 |
| PL367837A1 (en) | 2005-03-07 |
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