CY1106202T1 - Διαλυμα για την αποθηκευση και διαποτιση οργανων αναμενοντας μεταμοσχευση - Google Patents
Διαλυμα για την αποθηκευση και διαποτιση οργανων αναμενοντας μεταμοσχευσηInfo
- Publication number
- CY1106202T1 CY1106202T1 CY20061101484T CY061101484T CY1106202T1 CY 1106202 T1 CY1106202 T1 CY 1106202T1 CY 20061101484 T CY20061101484 T CY 20061101484T CY 061101484 T CY061101484 T CY 061101484T CY 1106202 T1 CY1106202 T1 CY 1106202T1
- Authority
- CY
- Cyprus
- Prior art keywords
- solution
- storage
- digestion
- physiologically acceptable
- awaiting transplantation
- Prior art date
Links
- 210000000056 organ Anatomy 0.000 title abstract 2
- 238000002054 transplantation Methods 0.000 title abstract 2
- 230000029087 digestion Effects 0.000 title 1
- 235000002639 sodium chloride Nutrition 0.000 abstract 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 abstract 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- -1 alkanoyl L-carnitine Chemical compound 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 239000002738 chelating agent Substances 0.000 abstract 1
- 239000001177 diphosphate Substances 0.000 abstract 1
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 abstract 1
- 235000011180 diphosphates Nutrition 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 150000004712 monophosphates Chemical class 0.000 abstract 1
- 230000010412 perfusion Effects 0.000 abstract 1
- 229910001414 potassium ion Inorganic materials 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 235000017557 sodium bicarbonate Nutrition 0.000 abstract 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 abstract 1
- UIIMBOGNXHQVGW-UHFFFAOYSA-M sodium bicarbonate Substances [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0226—Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Ένα διάλυμα αποθήκευσης για την διατήρηση και την διαπότιση οργάνων αναμένοντας μεταμόσχευση περιλαμβάνοντας (α) ένα ισοτονικό ισοσταθμισμένο διάλυμα περιλαμβάνοντας μία φυσιολογικώς αποδεκτή ποσότητα ιόντων καλίου, μονοόξινου φωσφορικού, διόξινου φωσφορικού, χλωριούχου νατρίου και διττανθρακικών˙ (β) 50-250 mM γλυκόζης˙ (γ) 0.2-20 mM μιας αλκανοϋλ L-καρνιτίνης ή ενός φυσιολογικώς αποδεκτού άλατος εξ' αυτής˙ (δ) 1-100 mM L-καρνιτίνης ή ενός φυσιολογικός αποδεκτού άλατος εξ' αυτής˙ (ε) περιγράφεται ύδωρ. Το διάλυμα αποθήκευσης μπορεί επίσης να συμπεριλαμβάνει και άλλα συστατικά όπως είναι τα αντι-οξειδωτικά και/ή τα χηλικά αντιδραστήρια.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2001RM000337A ITRM20010337A1 (it) | 2001-06-14 | 2001-06-14 | Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. |
PCT/IT2002/000391 WO2002102149A1 (en) | 2001-06-14 | 2002-06-13 | Solution for the storage and perfusion of organs awaiting transplantation |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106202T1 true CY1106202T1 (el) | 2011-06-08 |
Family
ID=11455594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101484T CY1106202T1 (el) | 2001-06-14 | 2006-10-16 | Διαλυμα για την αποθηκευση και διαποτιση οργανων αναμενοντας μεταμοσχευση |
Country Status (15)
Country | Link |
---|---|
US (3) | US7422844B2 (el) |
EP (1) | EP1401270B1 (el) |
JP (1) | JP4268036B2 (el) |
KR (1) | KR100844191B1 (el) |
AT (1) | ATE336166T1 (el) |
CA (1) | CA2450623C (el) |
CY (1) | CY1106202T1 (el) |
DE (1) | DE60213990T2 (el) |
DK (1) | DK1401270T3 (el) |
ES (1) | ES2271290T3 (el) |
IT (1) | ITRM20010337A1 (el) |
MX (1) | MXPA03011461A (el) |
PL (1) | PL206312B1 (el) |
PT (1) | PT1401270E (el) |
WO (1) | WO2002102149A1 (el) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITRM20010337A1 (it) * | 2001-06-14 | 2002-12-16 | Sigma Tau Ind Farmaceuti | Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. |
JP2005095152A (ja) * | 2003-08-29 | 2005-04-14 | Japan Tissue Engineering:Kk | 培養組織の保存方法 |
WO2006026304A1 (en) * | 2004-08-25 | 2006-03-09 | Ivax Corporation | Cardioprotective formulations and uses thereof |
TWI388318B (zh) * | 2005-03-10 | 2013-03-11 | Sigma Tau Ind Farmaceuti | 具有改良之生物相容性的含有肉毒鹼之腹膜透析溶液 |
JP2006347935A (ja) * | 2005-06-15 | 2006-12-28 | Masanori Ogata | 炎症性サイトカインの産生が関与する疾患の予防及び/又は治療のための医薬 |
GB0612877D0 (en) * | 2006-06-29 | 2006-08-09 | Univ Edinburgh | Organ preservation solution |
EP2124539A2 (en) | 2007-02-17 | 2009-12-02 | President and Fellows of Harvard College | Compositions and method for tissue preservation |
EP2252281A4 (en) | 2008-02-15 | 2011-08-24 | Harvard College | BLOOD SUBSTITUTION SOLUTION |
US9005920B2 (en) | 2009-06-15 | 2015-04-14 | Toyota Jidosha Kabushiki Kaisha | Solution for cell-free protein synthesis, kit for cell-free protein synthesis, and method of protein synthesis |
RU2707532C1 (ru) * | 2018-10-11 | 2019-11-27 | Российская Федерация, от имени которой выступает ФОНД ПЕРСПЕКТИВНЫХ ИССЛЕДОВАНИЙ | Способ повышения безопасности и эффективности хранения и транспортировки трансплантируемого органа под давлением консервирующей газовой смеси и устройство на его основе |
CN109511650B (zh) * | 2018-11-21 | 2021-06-15 | 嘉兴莱普晟医疗科技有限公司 | 一种可以扩大供肝来源的常温机械灌注液 |
IT201900007446A1 (it) | 2019-05-29 | 2020-11-29 | Giuseppe Castellano | Composizione comprendente citrato e carnitina in grado di attivare la produzione della proteina klotho |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5498427A (en) * | 1990-11-20 | 1996-03-12 | Pasteur Merieux Serums Et Vaccines | Solutions for the perfusion, preservation and reperfusion of organs |
IT1261695B (it) * | 1993-06-02 | 1996-05-29 | Sigma Tau Ind Farmaceuti | Impiego di l-carnitina e alcanoil l-carnitine nella conservazione del sangue per trasfusioni e soluzioni stabilizzatrici che le contengono. |
WO1996018293A1 (en) | 1994-12-12 | 1996-06-20 | Charlotte-Mecklenburg Hospital Authority | Organ transplant solutions and method for transplanting an organ |
US5707971A (en) | 1995-06-07 | 1998-01-13 | Life Resuscitation Technologies, Inc. | Modulation of glycolytic ATP production |
US5834178C1 (en) * | 1997-07-09 | 2002-04-23 | Univ Wayne State | Flush-storage solution for donor organs |
WO2000030637A1 (en) | 1998-11-26 | 2000-06-02 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of fumarate salt of l-carnitine or its alkanoyl derivatives in ischaemia |
WO2001026649A1 (en) * | 1999-10-11 | 2001-04-19 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Use of l-carnitine and its alkanoyl derivatives as osmotic agents in solutions for medical use |
ITRM20010337A1 (it) * | 2001-06-14 | 2002-12-16 | Sigma Tau Ind Farmaceuti | Soluzione per la conservazione e perfuzione di organi in attesa che vengano trapiantati. |
-
2001
- 2001-06-14 IT IT2001RM000337A patent/ITRM20010337A1/it unknown
-
2002
- 2002-06-13 ES ES02745791T patent/ES2271290T3/es not_active Expired - Lifetime
- 2002-06-13 AT AT02745791T patent/ATE336166T1/de active
- 2002-06-13 WO PCT/IT2002/000391 patent/WO2002102149A1/en active IP Right Grant
- 2002-06-13 US US10/480,824 patent/US7422844B2/en not_active Expired - Fee Related
- 2002-06-13 JP JP2003504747A patent/JP4268036B2/ja not_active Expired - Fee Related
- 2002-06-13 MX MXPA03011461A patent/MXPA03011461A/es active IP Right Grant
- 2002-06-13 CA CA2450623A patent/CA2450623C/en not_active Expired - Fee Related
- 2002-06-13 PT PT02745791T patent/PT1401270E/pt unknown
- 2002-06-13 PL PL367837A patent/PL206312B1/pl not_active IP Right Cessation
- 2002-06-13 DE DE60213990T patent/DE60213990T2/de not_active Expired - Lifetime
- 2002-06-13 EP EP02745791A patent/EP1401270B1/en not_active Expired - Lifetime
- 2002-06-13 KR KR1020037016372A patent/KR100844191B1/ko not_active IP Right Cessation
- 2002-06-13 DK DK02745791T patent/DK1401270T3/da active
-
2006
- 2006-10-16 CY CY20061101484T patent/CY1106202T1/el unknown
-
2008
- 2008-01-31 US US12/010,931 patent/US8007993B2/en not_active Expired - Fee Related
- 2008-02-01 US US12/068,055 patent/US7989158B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
KR100844191B1 (ko) | 2008-07-04 |
CA2450623C (en) | 2011-05-10 |
EP1401270A1 (en) | 2004-03-31 |
US7989158B2 (en) | 2011-08-02 |
ITRM20010337A1 (it) | 2002-12-16 |
DE60213990T2 (de) | 2007-03-15 |
PL367837A1 (en) | 2005-03-07 |
US8007993B2 (en) | 2011-08-30 |
DK1401270T3 (da) | 2006-12-27 |
ES2271290T3 (es) | 2007-04-16 |
US20080199844A1 (en) | 2008-08-21 |
EP1401270B1 (en) | 2006-08-16 |
ATE336166T1 (de) | 2006-09-15 |
PT1401270E (pt) | 2006-10-31 |
JP2004529205A (ja) | 2004-09-24 |
US20080166695A1 (en) | 2008-07-10 |
KR20040010712A (ko) | 2004-01-31 |
US20040156990A1 (en) | 2004-08-12 |
US7422844B2 (en) | 2008-09-09 |
DE60213990D1 (de) | 2006-09-28 |
MXPA03011461A (es) | 2004-07-01 |
PL206312B1 (pl) | 2010-07-30 |
JP4268036B2 (ja) | 2009-05-27 |
WO2002102149A1 (en) | 2002-12-27 |
ITRM20010337A0 (it) | 2001-06-14 |
CA2450623A1 (en) | 2002-12-27 |
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