DE60202681T2 - Verfahren zur herstellung des lna phosphoramidite - Google Patents

Verfahren zur herstellung des lna phosphoramidite Download PDF

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Publication number
DE60202681T2
DE60202681T2 DE60202681T DE60202681T DE60202681T2 DE 60202681 T2 DE60202681 T2 DE 60202681T2 DE 60202681 T DE60202681 T DE 60202681T DE 60202681 T DE60202681 T DE 60202681T DE 60202681 T2 DE60202681 T2 DE 60202681T2
Authority
DE
Germany
Prior art keywords
lna
cyanoethyl
phosphoramidite
ribo
tetraisopropylphosphoramidite
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60202681T
Other languages
German (de)
English (en)
Other versions
DE60202681D1 (de
Inventor
Troels Koch
Christoph Rosenbohm
Sejer Daniel PEDERSEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Roche Innovation Center Copenhagen AS
Original Assignee
Santaris Pharma AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santaris Pharma AS filed Critical Santaris Pharma AS
Publication of DE60202681D1 publication Critical patent/DE60202681D1/de
Application granted granted Critical
Publication of DE60202681T2 publication Critical patent/DE60202681T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Luminescent Compositions (AREA)
  • Saccharide Compounds (AREA)
DE60202681T 2001-07-12 2002-07-12 Verfahren zur herstellung des lna phosphoramidite Expired - Lifetime DE60202681T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA200101095 2001-07-12
DK200101095 2001-07-12
PCT/DK2002/000488 WO2003006475A2 (en) 2001-07-12 2002-07-12 Method for preparation of lna phosphoramidites

Publications (2)

Publication Number Publication Date
DE60202681D1 DE60202681D1 (de) 2005-02-24
DE60202681T2 true DE60202681T2 (de) 2006-01-12

Family

ID=8160624

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60202681T Expired - Lifetime DE60202681T2 (de) 2001-07-12 2002-07-12 Verfahren zur herstellung des lna phosphoramidite

Country Status (7)

Country Link
EP (1) EP1409497B1 (https=)
JP (1) JP4402454B2 (https=)
AT (1) ATE287413T1 (https=)
AU (1) AU2002328792A1 (https=)
DE (1) DE60202681T2 (https=)
DK (1) DK1409497T3 (https=)
WO (1) WO2003006475A2 (https=)

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WO2011105900A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
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Also Published As

Publication number Publication date
EP1409497A2 (en) 2004-04-21
EP1409497B1 (en) 2005-01-19
JP4402454B2 (ja) 2010-01-20
DE60202681D1 (de) 2005-02-24
WO2003006475A3 (en) 2004-02-26
WO2003006475A2 (en) 2003-01-23
ATE287413T1 (de) 2005-02-15
DK1409497T3 (da) 2005-05-30
AU2002328792A1 (en) 2003-01-29
JP2004536125A (ja) 2004-12-02

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