ATE287413T1 - Verfahren zur herstellung des lna phosphoramidite - Google Patents

Verfahren zur herstellung des lna phosphoramidite

Info

Publication number
ATE287413T1
ATE287413T1 AT02764561T AT02764561T ATE287413T1 AT E287413 T1 ATE287413 T1 AT E287413T1 AT 02764561 T AT02764561 T AT 02764561T AT 02764561 T AT02764561 T AT 02764561T AT E287413 T1 ATE287413 T1 AT E287413T1
Authority
AT
Austria
Prior art keywords
producing
cyanoethyl
phosphoramidite
lna
lna phosphoramidite
Prior art date
Application number
AT02764561T
Other languages
German (de)
English (en)
Inventor
Troels Koch
Christoph Rosenbohm
Daniel Sejer Pedersen
Original Assignee
Santaris Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Santaris Pharma As filed Critical Santaris Pharma As
Application granted granted Critical
Publication of ATE287413T1 publication Critical patent/ATE287413T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C07H1/02—Phosphorylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Luminescent Compositions (AREA)
  • Saccharide Compounds (AREA)
AT02764561T 2001-07-12 2002-07-12 Verfahren zur herstellung des lna phosphoramidite ATE287413T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200101095 2001-07-12
PCT/DK2002/000488 WO2003006475A2 (en) 2001-07-12 2002-07-12 Method for preparation of lna phosphoramidites

Publications (1)

Publication Number Publication Date
ATE287413T1 true ATE287413T1 (de) 2005-02-15

Family

ID=8160624

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02764561T ATE287413T1 (de) 2001-07-12 2002-07-12 Verfahren zur herstellung des lna phosphoramidite

Country Status (7)

Country Link
EP (1) EP1409497B1 (https=)
JP (1) JP4402454B2 (https=)
AT (1) ATE287413T1 (https=)
AU (1) AU2002328792A1 (https=)
DE (1) DE60202681T2 (https=)
DK (1) DK1409497T3 (https=)
WO (1) WO2003006475A2 (https=)

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ES2541442T3 (es) 2008-08-01 2015-07-20 Roche Innovation Center Copenhagen A/S Modulación mediada por microARN de factores estimulantes de colonias
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US8563528B2 (en) 2009-07-21 2013-10-22 Santaris Pharma A/S Antisense oligomers targeting PCSK9
WO2011105900A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
WO2011105901A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 9 (c9) and uses thereof
WO2011105902A2 (en) 2010-02-23 2011-09-01 Academisch Ziekenhuis Bij De Universiteit Van Amsterdam Antagonists of complement component 8-beta (c8-beta) and uses thereof
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WO2014108759A1 (en) 2013-01-14 2014-07-17 Pierfrancesco Tassone INHIBITORS OF miRNAs 221 AND 222 FOR ANTI-TUMOR ACTIVITY IN MULTIPLE MYELOMA
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CA3228833A1 (en) 2021-08-19 2023-02-23 Neumirna Therapeutics Aps Antisense oligonucleotides targeting adenosine kinase
JP7772362B2 (ja) * 2021-12-21 2025-11-18 シンクレスト株式会社 人工核酸モノマーの製造方法
WO2023152369A1 (en) 2022-02-14 2023-08-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Nucleic acid mir-9 inhibitor for the treatment of cystic fibrosis
EP4558149A1 (en) 2022-07-21 2025-05-28 Institut National de la Santé et de la Recherche Médicale Methods and compositions for treating chronic pain disorders
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EP4646478A1 (en) 2023-01-06 2025-11-12 Institut National de la Santé et de la Recherche Médicale Intravenous administration of antisense oligonucleotides for the treatment of pain
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Also Published As

Publication number Publication date
EP1409497A2 (en) 2004-04-21
EP1409497B1 (en) 2005-01-19
JP4402454B2 (ja) 2010-01-20
DE60202681D1 (de) 2005-02-24
WO2003006475A3 (en) 2004-02-26
WO2003006475A2 (en) 2003-01-23
DK1409497T3 (da) 2005-05-30
AU2002328792A1 (en) 2003-01-29
JP2004536125A (ja) 2004-12-02
DE60202681T2 (de) 2006-01-12

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