ATE270275T1 - Verfahren zur herstellung von 2-aryl-3-aryl-5- halogen-pyridinen, verwendbar als cox-2 inhibitoren - Google Patents
Verfahren zur herstellung von 2-aryl-3-aryl-5- halogen-pyridinen, verwendbar als cox-2 inhibitorenInfo
- Publication number
- ATE270275T1 ATE270275T1 AT98919881T AT98919881T ATE270275T1 AT E270275 T1 ATE270275 T1 AT E270275T1 AT 98919881 T AT98919881 T AT 98919881T AT 98919881 T AT98919881 T AT 98919881T AT E270275 T1 ATE270275 T1 AT E270275T1
- Authority
- AT
- Austria
- Prior art keywords
- aryl
- pyridines
- cox
- inhibitors
- usable
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/52—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4564297P | 1997-04-18 | 1997-04-18 | |
| GBGB9709686.1A GB9709686D0 (en) | 1997-05-13 | 1997-05-13 | Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors |
| PCT/US1998/008312 WO1998047871A1 (en) | 1997-04-18 | 1998-04-14 | Process for making 2-aryl-3-aryl-5-halo pyridines useful as cox-2 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE270275T1 true ATE270275T1 (de) | 2004-07-15 |
Family
ID=26311530
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98919881T ATE270275T1 (de) | 1997-04-18 | 1998-04-14 | Verfahren zur herstellung von 2-aryl-3-aryl-5- halogen-pyridinen, verwendbar als cox-2 inhibitoren |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP0975596B1 (de) |
| JP (1) | JP3300369B2 (de) |
| KR (1) | KR20010006546A (de) |
| CN (1) | CN1182117C (de) |
| AT (1) | ATE270275T1 (de) |
| AU (1) | AU729730B2 (de) |
| BR (1) | BR9808923B1 (de) |
| CA (1) | CA2287482C (de) |
| CZ (1) | CZ293246B6 (de) |
| DE (1) | DE69824839T2 (de) |
| EA (1) | EA002190B1 (de) |
| ES (1) | ES2223128T3 (de) |
| HK (1) | HK1023771A1 (de) |
| HR (1) | HRP980206B1 (de) |
| HU (1) | HU226999B1 (de) |
| NZ (1) | NZ500390A (de) |
| PL (1) | PL190265B1 (de) |
| RS (1) | RS49901B (de) |
| SK (1) | SK285037B6 (de) |
| TW (1) | TW492959B (de) |
| UA (1) | UA66792C2 (de) |
| WO (1) | WO1998047871A1 (de) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE253559T1 (de) * | 1999-01-14 | 2003-11-15 | Lonza Ag | Verfahren zur herstellung von 1-(6-methylpyridin- 3-yl)-2- 4-(methylsulfonyl phenyl)ethanon |
| MXPA01007169A (es) | 1999-01-14 | 2003-06-06 | Lonza Ag | 1-(6-metilpiridin-3-il)-2-(4-(metilsulfonil)fenil)etanona y metodo para su elaboracion. |
| US6566527B1 (en) | 1999-07-27 | 2003-05-20 | Merck & Co., Inc. | Process for preparing 1-(6-methylpyridin-3-yl)-2-[4-methylsulphonyl)-phenyl]ethanone |
| JP4773013B2 (ja) * | 1999-07-27 | 2011-09-14 | ロンザ アーゲー | １−（６−メチルピリジン−３−イル）−２−［４−（メチルスルホニル）フェニル］エタノンの製造方法 |
| NZ519781A (en) | 1999-12-23 | 2004-04-30 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use |
| JP2001261647A (ja) * | 2000-03-22 | 2001-09-26 | Sankio Chemical Co Ltd | ピリジン誘導体の製造方法 |
| DK1303265T3 (da) | 2000-07-20 | 2007-11-12 | Lauras As | Anvendelse af COX-2-inhibitorer, som immunostimulerende midler ved behandling af HIV eller AIDS |
| EP2582690B1 (de) * | 2010-06-16 | 2018-07-25 | Glenmark Generics Limited | Verfahren zur herstellung von 2,3-diaryl-5-substituierten pyridinen und deren zwischenstoffen |
| MY163379A (en) * | 2010-11-15 | 2017-09-15 | Virdev Intermediates Pvt Ltd | A process for cyclooxygenase-2 selective inhibitor |
| CN103204803A (zh) | 2012-01-13 | 2013-07-17 | 阿尔弗雷德·E·蒂芬巴赫尔有限责任两合公司 | 用于合成依托考昔的方法 |
| WO2014114352A1 (en) * | 2013-01-25 | 2014-07-31 | Synthon Bv | Process for making etoricoxib |
| WO2015036550A1 (en) | 2013-09-13 | 2015-03-19 | Synthon B.V. | Process for making etoricoxib |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH561716A5 (de) * | 1971-05-10 | 1975-05-15 | Ciba Geigy Ag | |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5686470A (en) * | 1995-02-10 | 1997-11-11 | Weier; Richard M. | 2, 3-substituted pyridines for the treatment of inflammation |
| WO1996025405A1 (en) * | 1995-02-13 | 1996-08-22 | G.D. Searle & Co. | Substituted isoxazoles for the treatment of inflammation |
| US5643933A (en) * | 1995-06-02 | 1997-07-01 | G. D. Searle & Co. | Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors |
| US5677318A (en) * | 1996-07-11 | 1997-10-14 | Merck Frosst Canada, Inc. | Diphenyl-1,2-3-thiadiazoles as anti-inflammatory agents |
| HU227732B1 (en) * | 1996-07-18 | 2012-01-30 | Merck Frosst Canada Ltd | Substituted pyridine derivatives as selective cyclooxigenase-2 inhibitors and use thereof |
-
1998
- 1998-04-09 TW TW087105349A patent/TW492959B/zh not_active IP Right Cessation
- 1998-04-14 ES ES98919881T patent/ES2223128T3/es not_active Expired - Lifetime
- 1998-04-14 EP EP98919881A patent/EP0975596B1/de not_active Expired - Lifetime
- 1998-04-14 CZ CZ19993690A patent/CZ293246B6/cs not_active IP Right Cessation
- 1998-04-14 HU HU0003155A patent/HU226999B1/hu not_active IP Right Cessation
- 1998-04-14 SK SK1436-99A patent/SK285037B6/sk not_active IP Right Cessation
- 1998-04-14 RS YUP-536/99A patent/RS49901B/sr unknown
- 1998-04-14 AT AT98919881T patent/ATE270275T1/de not_active IP Right Cessation
- 1998-04-14 BR BRPI9808923-4A patent/BR9808923B1/pt not_active IP Right Cessation
- 1998-04-14 EA EA199900948A patent/EA002190B1/ru not_active IP Right Cessation
- 1998-04-14 CA CA002287482A patent/CA2287482C/en not_active Expired - Fee Related
- 1998-04-14 CN CNB988061864A patent/CN1182117C/zh not_active Expired - Fee Related
- 1998-04-14 DE DE69824839T patent/DE69824839T2/de not_active Expired - Lifetime
- 1998-04-14 PL PL98336298A patent/PL190265B1/pl not_active IP Right Cessation
- 1998-04-14 AU AU72571/98A patent/AU729730B2/en not_active Ceased
- 1998-04-14 NZ NZ500390A patent/NZ500390A/en unknown
- 1998-04-14 WO PCT/US1998/008312 patent/WO1998047871A1/en active IP Right Grant
- 1998-04-14 JP JP54636798A patent/JP3300369B2/ja not_active Expired - Fee Related
- 1998-04-14 KR KR1019997009636A patent/KR20010006546A/ko not_active IP Right Cessation
- 1998-04-14 UA UA99116266A patent/UA66792C2/uk unknown
- 1998-04-16 HR HR980206A patent/HRP980206B1/xx not_active IP Right Cessation
-
2000
- 2000-05-16 HK HK00102924A patent/HK1023771A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |