DE69030745T2 - Verfahren und Reagens zur Sulfurierung von Organophosphiten - Google Patents

Verfahren und Reagens zur Sulfurierung von Organophosphiten

Info

Publication number
DE69030745T2
DE69030745T2 DE69030745T DE69030745T DE69030745T2 DE 69030745 T2 DE69030745 T2 DE 69030745T2 DE 69030745 T DE69030745 T DE 69030745T DE 69030745 T DE69030745 T DE 69030745T DE 69030745 T2 DE69030745 T2 DE 69030745T2
Authority
DE
Germany
Prior art keywords
tertiary amine
organophosphites
sulfurization
reagent
amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69030745T
Other languages
English (en)
Other versions
DE69030745D1 (de
Inventor
Ram S Bhatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gen Probe Inc
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of DE69030745D1 publication Critical patent/DE69030745D1/de
Publication of DE69030745T2 publication Critical patent/DE69030745T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
DE69030745T 1989-03-06 1990-03-06 Verfahren und Reagens zur Sulfurierung von Organophosphiten Expired - Fee Related DE69030745T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/319,570 US5449769A (en) 1989-03-06 1989-03-06 Method and reagent for sulfurization of organophosphorous compounds

Publications (2)

Publication Number Publication Date
DE69030745D1 DE69030745D1 (de) 1997-06-26
DE69030745T2 true DE69030745T2 (de) 1997-09-11

Family

ID=23242812

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69030745T Expired - Fee Related DE69030745T2 (de) 1989-03-06 1990-03-06 Verfahren und Reagens zur Sulfurierung von Organophosphiten

Country Status (9)

Country Link
US (2) US5449769A (de)
EP (1) EP0386987B1 (de)
JP (1) JP2898750B2 (de)
AT (1) ATE153343T1 (de)
CA (1) CA2011430C (de)
DE (1) DE69030745T2 (de)
DK (1) DK0386987T3 (de)
ES (1) ES2101689T3 (de)
WO (1) WO1990011322A2 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
US5683985A (en) * 1991-04-18 1997-11-04 The Salk Institute For Biological Studies Oligonucleotide decoys and methods relating thereto
IT1249732B (it) * 1991-11-26 1995-03-09 Angeletti P Ist Richerche Bio Oligonucleotidi antisenso.
CA2140542A1 (en) * 1992-07-27 1994-02-03 Abeysingle Padmapriya Oligonucleotide alkylphosphonothioates
DE69402177T2 (de) * 1993-01-08 1997-06-26 Hybridon Inc Synthese von dimer-blöcken und ihre verwendung bei der zusammensetzung von oligonukleotiden
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
JPH08508714A (ja) * 1993-01-25 1996-09-17 ハイブライドン インコーポレイテッド オリゴヌクレオチド・アルキルホスホネートおよびアルキルホスホノチオエート
US5739309A (en) * 1993-07-19 1998-04-14 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens
US5733781A (en) 1994-07-19 1998-03-31 Gen-Probe Incorporated Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
AU689375B2 (en) * 1995-01-19 1998-03-26 Gen-Probe Incorporated Nucleic acid amplification oligonucleotides and probes to lyme disease associated borrelia
US5674995A (en) * 1995-06-07 1997-10-07 Gen-Probe Incorporated Oligonucleotides specific for cytokine signal transducer gp130 mRNA
US5747470A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
US5716846A (en) * 1995-06-07 1998-02-10 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA
US6172217B1 (en) 1996-12-27 2001-01-09 Isis Pharmaceuticals Inc. Method of synthesizing phosphorothioate oligonucleotides
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US5760209A (en) * 1997-03-03 1998-06-02 Isis Pharmaceuticals, Inc. Protecting group for synthesizing oligonucleotide analogs
US5902881A (en) * 1997-03-03 1999-05-11 Isis Pharmaceuticals, Inc. Reagent useful for synthesizing sulfurized oligonucleotide analogs
US6110678A (en) 1997-05-02 2000-08-29 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6995259B1 (en) * 1998-10-23 2006-02-07 Sirna Therapeutics, Inc. Method for the chemical synthesis of oligonucleotides
AU2001284268A1 (en) * 2000-09-07 2002-03-22 Avecia Biotechnology, Inc. Synthons for oligonucleotide synthesis
US7205399B1 (en) * 2001-07-06 2007-04-17 Sirna Therapeutics, Inc. Methods and reagents for oligonucleotide synthesis
CA2525413C (en) 2003-05-19 2010-08-17 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample
EP3159417B1 (de) 2006-08-01 2021-10-06 Gen-Probe Incorporated Verfahren zur nichtspezifischen zielerfassung von nukleinsäuren
US8309710B2 (en) * 2009-06-29 2012-11-13 Agilent Technologies, Inc. Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide
WO2018209068A1 (en) 2017-05-11 2018-11-15 Gen-Probe Incorporated Compositions and methods for isolating target nucleic acids
CA3108105A1 (en) 2018-08-08 2020-02-13 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
WO2021041056A1 (en) 2019-08-23 2021-03-04 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
EP4025715A1 (de) 2019-09-05 2022-07-13 Gen-Probe Incorporated Nachweis von chlamydia-trachomatis-nukleinsäurevarianten
CA3159392A1 (en) 2019-11-14 2021-05-20 Gen-Probe Incorporated Compositions and methods for capturing target nucleic acids
EP4337797A1 (de) 2021-05-14 2024-03-20 Gen-Probe Incorporated Zusammensetzungen und verfahren zum nachweis von humaner adenovirus-nukleinsäure
AU2022319876A1 (en) 2021-07-27 2024-01-18 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA661668A (en) * 1963-04-23 H. Ford-Moore Arthur Manufacture of organic phosphorus compounds
US2536647A (en) * 1948-03-06 1951-01-02 Monsanto Chemicals Process of preparing bis (beta-chlorethyl)-para-nitrophenyl thiophosphate
US2647140A (en) * 1949-04-16 1953-07-28 Bayer Ag Process for the production of dialkylthiophosphates
US2907787A (en) * 1957-11-13 1959-10-06 Friedrich W Hoffmann Preparation of phosphono-thiono esters of 2-hydroxyethyl sulfides
DE1126382B (de) * 1960-08-17 1962-03-29 Bayer Ag Verfahren zur Herstellung von Thiophosphorsaeureestern
NL136286C (de) * 1962-01-24
US3162570A (en) * 1962-05-21 1964-12-22 Socony Mobil Oil Co Inc Organophosphorus compounds as insecticides and nematocides
GB1346409A (en) * 1962-06-21 1974-02-13 Secr Defence Manufacture of organic phosphorous compounds containing sulphur
US3296221A (en) * 1963-05-13 1967-01-03 Phillips Petroleum Co Mercapto-substituted thio-phosphites and phosphates and polysulfide polymers thereof
DE1210834B (de) * 1964-07-01 1966-02-17 Bayer Ag Verfahren zur Herstellung von Thiophosphorverbindungen
US3687808A (en) * 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
SU410021A1 (de) * 1972-05-30 1974-01-05
US4197209A (en) * 1977-03-10 1980-04-08 Ciba-Geigy Corporation Lubricant compositions containing sulfur-containing esters of phosphoric acid
US4625677A (en) * 1985-05-23 1986-12-02 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Apparatus for coating and polishing a micropipette

Also Published As

Publication number Publication date
WO1990011322A3 (en) 1991-04-04
EP0386987A1 (de) 1990-09-12
EP0386987B1 (de) 1997-05-21
WO1990011322A2 (en) 1990-10-04
JPH04503956A (ja) 1992-07-16
DE69030745D1 (de) 1997-06-26
JP2898750B2 (ja) 1999-06-02
ATE153343T1 (de) 1997-06-15
ES2101689T3 (es) 1997-07-16
CA2011430C (en) 2000-06-20
DK0386987T3 (da) 1997-10-13
US5252723A (en) 1993-10-12
CA2011430A1 (en) 1990-09-06
US5449769A (en) 1995-09-12

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee