ES2101689T3 - Metodo y reactivo para la sulfuracion de compuestos organofosforosos. - Google Patents

Metodo y reactivo para la sulfuracion de compuestos organofosforosos.

Info

Publication number
ES2101689T3
ES2101689T3 ES90302337T ES90302337T ES2101689T3 ES 2101689 T3 ES2101689 T3 ES 2101689T3 ES 90302337 T ES90302337 T ES 90302337T ES 90302337 T ES90302337 T ES 90302337T ES 2101689 T3 ES2101689 T3 ES 2101689T3
Authority
ES
Spain
Prior art keywords
organophosphous
sulfuration
reagent
compounds
tertiary amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90302337T
Other languages
English (en)
Inventor
Ram S Bhatt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gen Probe Inc
Original Assignee
Gen Probe Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gen Probe Inc filed Critical Gen Probe Inc
Application granted granted Critical
Publication of ES2101689T3 publication Critical patent/ES2101689T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
    • C07F9/165—Esters of thiophosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

UNA COMPOSICION CONVENIENTE PARA SULFURIZAR UN ORGANOFOSFORITO COMPRENDE UNA SOLUCION DE SULFURO Y UNA AMINA TERCIARIA, EN UN SOLVENTE CONVENIENTE TAL COMO DISULFURO DE CARBON. LA AMINA TERCIARIA ES PREFERIBLEMENTE UNA AMINA TRIALQUIL OPCIONALMENTE SUSTITUIDA, POR EJEMPLO TRIETILAMINA O DIDISOPROPILETILAMINA. LOS ESTERES FOSFITOS O FOSFOROSO DEBEN SER SULFURIZADOS A SUS CORRESPONDIENTES FOSFOROTIOATO O FOSFONOTIOATO, RESPECTIVAMENTE, USANDO ESAS COMPOSICIONES Y ESTO ES PARTICULARMENTE UTIL EN PRODUCIR FOSFOROTIOATO O FOSFONOTIOATO INTERNUCLEOTIDO EN UN MULTIMERO NUCLEOTIDO.
ES90302337T 1989-03-06 1990-03-06 Metodo y reactivo para la sulfuracion de compuestos organofosforosos. Expired - Lifetime ES2101689T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/319,570 US5449769A (en) 1989-03-06 1989-03-06 Method and reagent for sulfurization of organophosphorous compounds

Publications (1)

Publication Number Publication Date
ES2101689T3 true ES2101689T3 (es) 1997-07-16

Family

ID=23242812

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90302337T Expired - Lifetime ES2101689T3 (es) 1989-03-06 1990-03-06 Metodo y reactivo para la sulfuracion de compuestos organofosforosos.

Country Status (9)

Country Link
US (2) US5449769A (es)
EP (1) EP0386987B1 (es)
JP (1) JP2898750B2 (es)
AT (1) ATE153343T1 (es)
CA (1) CA2011430C (es)
DE (1) DE69030745T2 (es)
DK (1) DK0386987T3 (es)
ES (1) ES2101689T3 (es)
WO (1) WO1990011322A2 (es)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5714380A (en) 1986-10-23 1998-02-03 Amoco Corporation Closed vessel for isolating target molecules and for performing amplification
WO1992018522A1 (en) * 1991-04-18 1992-10-29 The Salk Institute For Biological Studies Oligodeoxynucleotides and oligonucleotides useful as decoys for proteins which selectively bind to defined dna sequences
IT1249732B (it) * 1991-11-26 1995-03-09 Angeletti P Ist Richerche Bio Oligonucleotidi antisenso.
ATE162198T1 (de) * 1992-07-27 1998-01-15 Hybridon Inc Oligonukleotid alkylphosphonothiate
US6087491A (en) 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
JPH08507752A (ja) * 1993-01-08 1996-08-20 ハイブライドン インコーポレイテッド 二量体ブロックの合成と二量体ブロックを使ったオリゴヌクレオチド結合法
EP0677056B1 (en) * 1993-01-25 1996-05-22 HYBRIDON, Inc. Oligonucleotide alkylphosphonates and alkylphosphonothioates
US5739309A (en) * 1993-07-19 1998-04-14 Gen-Probe Incorporated Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens
US5733781A (en) 1994-07-19 1998-03-31 Gen-Probe Incorporated Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus
US5514551A (en) * 1994-10-14 1996-05-07 Gen-Probe Incorporated Compositions for the detection of Chlamydia trachomatis
ATE194391T1 (de) * 1995-01-19 2000-07-15 Gen Probe Inc Amplifikationsoligonukleotide und sonden für borrelia, die mit lyme kranheit assoziiert sind
US5674995A (en) * 1995-06-07 1997-10-07 Gen-Probe Incorporated Oligonucleotides specific for cytokine signal transducer gp130 mRNA
US5716846A (en) * 1995-06-07 1998-02-10 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA
US5747470A (en) * 1995-06-07 1998-05-05 Gen-Probe Incorporated Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA
US6172217B1 (en) * 1996-12-27 2001-01-09 Isis Pharmaceuticals Inc. Method of synthesizing phosphorothioate oligonucleotides
US6025133A (en) * 1996-12-30 2000-02-15 Gen-Probe Incorporated Promoter-sequestered oligonucleoside and method of use
US5902881A (en) * 1997-03-03 1999-05-11 Isis Pharmaceuticals, Inc. Reagent useful for synthesizing sulfurized oligonucleotide analogs
US5760209A (en) * 1997-03-03 1998-06-02 Isis Pharmaceuticals, Inc. Protecting group for synthesizing oligonucleotide analogs
US6534273B2 (en) 1997-05-02 2003-03-18 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
WO1998050583A1 (en) 1997-05-02 1998-11-12 Gen-Probe Incorporated Two-step hybridization and capture of a polynucleotide
US6995259B1 (en) * 1998-10-23 2006-02-07 Sirna Therapeutics, Inc. Method for the chemical synthesis of oligonucleotides
JP2004508379A (ja) * 2000-09-07 2004-03-18 アベシア・バイオテクノロジー・インコーポレーテッド オリゴヌクレオチド合成用のシントン
US7205399B1 (en) * 2001-07-06 2007-04-17 Sirna Therapeutics, Inc. Methods and reagents for oligonucleotide synthesis
EP1633893B1 (en) 2003-05-19 2012-01-25 Gen-Probe Incorporated Compositions, methods and kits for determining the presence of trichomonas vaginalis in a test sample
US9051601B2 (en) 2006-08-01 2015-06-09 Gen-Probe Incorporated Methods of nonspecific target capture of nucleic acids
US8309710B2 (en) * 2009-06-29 2012-11-13 Agilent Technologies, Inc. Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide
CN110612354A (zh) 2017-05-11 2019-12-24 简·探针公司 用于分离靶核酸的组合物和方法
US20210310059A1 (en) 2018-08-08 2021-10-07 Gen-Probe Incorporated Compositions, methods and kits for detecting mycoplasma genitalium
US20220298548A1 (en) 2019-08-23 2022-09-22 Gen-Probe Incorporated Compositions, methods and kits for detecting treponema pallidum
WO2021046270A1 (en) 2019-09-05 2021-03-11 Gen-Probe Incorporated Detection of chlamydia trachomatis nucleic acid variants
US20220396786A1 (en) 2019-11-14 2022-12-15 Gen-Probe Incorporated Compositions and Methods for Capturing Target Nucleic Acids
AU2022273052A1 (en) 2021-05-14 2023-11-30 Gen-Probe Incorporated Compositions and methods for detecting human adenovirus nucleic acid
AU2022319876A1 (en) 2021-07-27 2024-01-18 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2024137379A2 (en) 2022-12-19 2024-06-27 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal pathogens
WO2024192338A1 (en) 2023-03-16 2024-09-19 Gen-Probe Incorporated Compositions and methods for detecting gastrointestinal parasites

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA661668A (en) * 1963-04-23 H. Ford-Moore Arthur Manufacture of organic phosphorus compounds
US2536647A (en) * 1948-03-06 1951-01-02 Monsanto Chemicals Process of preparing bis (beta-chlorethyl)-para-nitrophenyl thiophosphate
US2647140A (en) * 1949-04-16 1953-07-28 Bayer Ag Process for the production of dialkylthiophosphates
US2907787A (en) * 1957-11-13 1959-10-06 Friedrich W Hoffmann Preparation of phosphono-thiono esters of 2-hydroxyethyl sulfides
DE1126382B (de) * 1960-08-17 1962-03-29 Bayer Ag Verfahren zur Herstellung von Thiophosphorsaeureestern
NL136286C (es) * 1962-01-24
US3162570A (en) * 1962-05-21 1964-12-22 Socony Mobil Oil Co Inc Organophosphorus compounds as insecticides and nematocides
GB1346409A (en) * 1962-06-21 1974-02-13 Secr Defence Manufacture of organic phosphorous compounds containing sulphur
US3296221A (en) * 1963-05-13 1967-01-03 Phillips Petroleum Co Mercapto-substituted thio-phosphites and phosphates and polysulfide polymers thereof
DE1210834B (de) * 1964-07-01 1966-02-17 Bayer Ag Verfahren zur Herstellung von Thiophosphorverbindungen
US3687808A (en) * 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
SU410021A1 (es) * 1972-05-30 1974-01-05
US4197209A (en) * 1977-03-10 1980-04-08 Ciba-Geigy Corporation Lubricant compositions containing sulfur-containing esters of phosphoric acid
US4625677A (en) * 1985-05-23 1986-12-02 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Apparatus for coating and polishing a micropipette

Also Published As

Publication number Publication date
CA2011430C (en) 2000-06-20
WO1990011322A3 (en) 1991-04-04
EP0386987A1 (en) 1990-09-12
ATE153343T1 (de) 1997-06-15
DK0386987T3 (da) 1997-10-13
US5252723A (en) 1993-10-12
JPH04503956A (ja) 1992-07-16
EP0386987B1 (en) 1997-05-21
US5449769A (en) 1995-09-12
WO1990011322A2 (en) 1990-10-04
DE69030745T2 (de) 1997-09-11
DE69030745D1 (de) 1997-06-26
JP2898750B2 (ja) 1999-06-02
CA2011430A1 (en) 1990-09-06

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