DK0386987T3 - Fremgangsmåde og reagens til svovling af organiske phosphorforbindelser - Google Patents
Fremgangsmåde og reagens til svovling af organiske phosphorforbindelserInfo
- Publication number
- DK0386987T3 DK0386987T3 DK90302337.2T DK90302337T DK0386987T3 DK 0386987 T3 DK0386987 T3 DK 0386987T3 DK 90302337 T DK90302337 T DK 90302337T DK 0386987 T3 DK0386987 T3 DK 0386987T3
- Authority
- DK
- Denmark
- Prior art keywords
- sulfurization
- reagent
- phosphorus compounds
- organic phosphorus
- tertiary amine
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000002903 organophosphorus compounds Chemical class 0.000 title 1
- 238000005987 sulfurization reaction Methods 0.000 title 1
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- FUWGSUOSJRCEIV-UHFFFAOYSA-N phosphonothioic O,O-acid Chemical class OP(O)=S FUWGSUOSJRCEIV-UHFFFAOYSA-N 0.000 abstract 2
- 150000003512 tertiary amines Chemical class 0.000 abstract 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-N Thiophosphoric acid Chemical class OP(O)(S)=O RYYWUUFWQRZTIU-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 150000008301 phosphite esters Chemical class 0.000 abstract 1
- AQSJGOWTSHOLKH-UHFFFAOYSA-N phosphite(3-) Chemical class [O-]P([O-])[O-] AQSJGOWTSHOLKH-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 abstract 1
- 125000005270 trialkylamine group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/16—Esters of thiophosphoric acids or thiophosphorous acids
- C07F9/165—Esters of thiophosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
- C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/319,570 US5449769A (en) | 1989-03-06 | 1989-03-06 | Method and reagent for sulfurization of organophosphorous compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
DK0386987T3 true DK0386987T3 (da) | 1997-10-13 |
Family
ID=23242812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK90302337.2T DK0386987T3 (da) | 1989-03-06 | 1990-03-06 | Fremgangsmåde og reagens til svovling af organiske phosphorforbindelser |
Country Status (9)
Country | Link |
---|---|
US (2) | US5449769A (da) |
EP (1) | EP0386987B1 (da) |
JP (1) | JP2898750B2 (da) |
AT (1) | ATE153343T1 (da) |
CA (1) | CA2011430C (da) |
DE (1) | DE69030745T2 (da) |
DK (1) | DK0386987T3 (da) |
ES (1) | ES2101689T3 (da) |
WO (1) | WO1990011322A2 (da) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5714380A (en) | 1986-10-23 | 1998-02-03 | Amoco Corporation | Closed vessel for isolating target molecules and for performing amplification |
JPH06509704A (ja) * | 1991-04-18 | 1994-11-02 | ザ ソールク インスチチュート フォア バイオロジカル スタディズ | 特定dna配列に選択的に結合する蛋白質に対する偽構築体として有用なオリゴデオキシヌクレオチドおよびオリゴヌクレオチド |
IT1249732B (it) * | 1991-11-26 | 1995-03-09 | Angeletti P Ist Richerche Bio | Oligonucleotidi antisenso. |
RU95104940A (ru) * | 1992-07-27 | 1997-01-10 | Хайбрайдон | Способ введения в олигонуклеотид алкилфосфонотиоатной или арилфосфонотиоатной межнуклеотидной связи, способ получения олигонуклеотида, олигонуклеотиды, способ ингибирования генной экспрессии, способ лечения |
ES2100051T3 (es) * | 1993-01-08 | 1997-06-01 | Hybridon Inc | Sintesis de bloques dimeros y su uso en el ensamblaje de oligonucleotidos. |
US6087491A (en) * | 1993-01-08 | 2000-07-11 | Hybridon, Inc. | Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks |
JPH08508714A (ja) * | 1993-01-25 | 1996-09-17 | ハイブライドン インコーポレイテッド | オリゴヌクレオチド・アルキルホスホネートおよびアルキルホスホノチオエート |
US5739309A (en) * | 1993-07-19 | 1998-04-14 | Gen-Probe Incorporated | Enhancement of oligonucleotide inhibition of protein production, cell proliferation and / or multiplication of infectious disease pathogens |
US5733781A (en) | 1994-07-19 | 1998-03-31 | Gen-Probe Incorporated | Oligonucleotides and methods for inhibiting propagation of human immunodeficiency virus |
US5514551A (en) * | 1994-10-14 | 1996-05-07 | Gen-Probe Incorporated | Compositions for the detection of Chlamydia trachomatis |
ES2150103T3 (es) * | 1995-01-19 | 2000-11-16 | Gen Probe Inc | Oligonucleotidos de amplificacion de acido nucleico y sondas para borrelia asociados con la enfermedad de lyme. |
US5716846A (en) * | 1995-06-07 | 1998-02-10 | Gen-Probe Incorporated | Method for inhibiting cellular proliferation using antisense oligonucleotides to interleukin-6 receptor mRNA |
US5674995A (en) * | 1995-06-07 | 1997-10-07 | Gen-Probe Incorporated | Oligonucleotides specific for cytokine signal transducer gp130 mRNA |
US5747470A (en) * | 1995-06-07 | 1998-05-05 | Gen-Probe Incorporated | Method for inhibiting cellular proliferation using antisense oligonucleotides to gp130 mRNA |
US6172217B1 (en) | 1996-12-27 | 2001-01-09 | Isis Pharmaceuticals Inc. | Method of synthesizing phosphorothioate oligonucleotides |
US6025133A (en) * | 1996-12-30 | 2000-02-15 | Gen-Probe Incorporated | Promoter-sequestered oligonucleoside and method of use |
US5902881A (en) | 1997-03-03 | 1999-05-11 | Isis Pharmaceuticals, Inc. | Reagent useful for synthesizing sulfurized oligonucleotide analogs |
US5760209A (en) * | 1997-03-03 | 1998-06-02 | Isis Pharmaceuticals, Inc. | Protecting group for synthesizing oligonucleotide analogs |
US6110678A (en) | 1997-05-02 | 2000-08-29 | Gen-Probe Incorporated | Two-step hybridization and capture of a polynucleotide |
US6534273B2 (en) | 1997-05-02 | 2003-03-18 | Gen-Probe Incorporated | Two-step hybridization and capture of a polynucleotide |
US6995259B1 (en) * | 1998-10-23 | 2006-02-07 | Sirna Therapeutics, Inc. | Method for the chemical synthesis of oligonucleotides |
DE60109047T2 (de) * | 2000-09-07 | 2006-04-06 | Avecia Biotechnology, Inc., Milford | Synthone zur herstellung von oligonukleotiden |
US7205399B1 (en) * | 2001-07-06 | 2007-04-17 | Sirna Therapeutics, Inc. | Methods and reagents for oligonucleotide synthesis |
EP2292793B1 (en) | 2003-05-19 | 2013-12-04 | Gen-Probe Incorporated | Compositions, methods and kits for determining the presence of Trichomonas Vaginalis in a test sample |
EP3159417B1 (en) | 2006-08-01 | 2021-10-06 | Gen-Probe Incorporated | Methods of nonspecific target capture of nucleic acids |
US8309710B2 (en) | 2009-06-29 | 2012-11-13 | Agilent Technologies, Inc. | Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide |
CA3062075C (en) | 2017-05-11 | 2024-04-02 | Gen-Probe Incorporated | Compositions and methods for isolating target nucleic acids |
CA3108105A1 (en) | 2018-08-08 | 2020-02-13 | Gen-Probe Incorporated | Compositions, methods and kits for detecting mycoplasma genitalium |
WO2021041056A1 (en) | 2019-08-23 | 2021-03-04 | Gen-Probe Incorporated | Compositions, methods and kits for detecting treponema pallidum |
EP4025715A1 (en) | 2019-09-05 | 2022-07-13 | Gen-Probe Incorporated | Detection of chlamydia trachomatis nucleic acid variants |
CN116287111A (zh) | 2019-11-14 | 2023-06-23 | 简·探针公司 | 用于捕获靶核酸的组合物和方法 |
US20240218469A1 (en) | 2021-05-14 | 2024-07-04 | Gen-Probe Incorporated | Compositions and methods for detecting human adenovirus nucleic acid |
EP4382621A3 (en) | 2021-07-27 | 2024-08-21 | Gen-Probe Incorporated | Compositions and methods for detecting c. coli and at least one of salmonella, c. jejuni, shigella, and stec |
WO2024137379A2 (en) | 2022-12-19 | 2024-06-27 | Gen-Probe Incorporated | Compositions and methods for detecting gastrointestinal pathogens |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA661668A (en) * | 1963-04-23 | H. Ford-Moore Arthur | Manufacture of organic phosphorus compounds | |
US2536647A (en) * | 1948-03-06 | 1951-01-02 | Monsanto Chemicals | Process of preparing bis (beta-chlorethyl)-para-nitrophenyl thiophosphate |
US2647140A (en) * | 1949-04-16 | 1953-07-28 | Bayer Ag | Process for the production of dialkylthiophosphates |
US2907787A (en) * | 1957-11-13 | 1959-10-06 | Friedrich W Hoffmann | Preparation of phosphono-thiono esters of 2-hydroxyethyl sulfides |
DE1126382B (de) * | 1960-08-17 | 1962-03-29 | Bayer Ag | Verfahren zur Herstellung von Thiophosphorsaeureestern |
NL288076A (da) * | 1962-01-24 | |||
US3162570A (en) * | 1962-05-21 | 1964-12-22 | Socony Mobil Oil Co Inc | Organophosphorus compounds as insecticides and nematocides |
GB1346409A (en) * | 1962-06-21 | 1974-02-13 | Secr Defence | Manufacture of organic phosphorous compounds containing sulphur |
US3296221A (en) * | 1963-05-13 | 1967-01-03 | Phillips Petroleum Co | Mercapto-substituted thio-phosphites and phosphates and polysulfide polymers thereof |
DE1210834B (de) * | 1964-07-01 | 1966-02-17 | Bayer Ag | Verfahren zur Herstellung von Thiophosphorverbindungen |
US3687808A (en) * | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
SU410021A1 (da) * | 1972-05-30 | 1974-01-05 | ||
US4189453A (en) * | 1977-03-10 | 1980-02-19 | Ciba-Geigy Corporation | Processes for the production of sulphur-containing esters of phosphoric acid and phosphorous acid |
US4625677A (en) * | 1985-05-23 | 1986-12-02 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. | Apparatus for coating and polishing a micropipette |
-
1989
- 1989-03-06 US US07/319,570 patent/US5449769A/en not_active Expired - Lifetime
-
1990
- 1990-03-02 WO PCT/US1990/000970 patent/WO1990011322A2/en unknown
- 1990-03-02 JP JP2504408A patent/JP2898750B2/ja not_active Expired - Fee Related
- 1990-03-05 CA CA002011430A patent/CA2011430C/en not_active Expired - Lifetime
- 1990-03-06 AT AT90302337T patent/ATE153343T1/de not_active IP Right Cessation
- 1990-03-06 DE DE69030745T patent/DE69030745T2/de not_active Expired - Fee Related
- 1990-03-06 EP EP90302337A patent/EP0386987B1/en not_active Expired - Lifetime
- 1990-03-06 DK DK90302337.2T patent/DK0386987T3/da active
- 1990-03-06 ES ES90302337T patent/ES2101689T3/es not_active Expired - Lifetime
- 1990-11-27 US US07/618,629 patent/US5252723A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5449769A (en) | 1995-09-12 |
WO1990011322A2 (en) | 1990-10-04 |
CA2011430C (en) | 2000-06-20 |
JP2898750B2 (ja) | 1999-06-02 |
EP0386987B1 (en) | 1997-05-21 |
DE69030745D1 (de) | 1997-06-26 |
US5252723A (en) | 1993-10-12 |
CA2011430A1 (en) | 1990-09-06 |
WO1990011322A3 (en) | 1991-04-04 |
EP0386987A1 (en) | 1990-09-12 |
ATE153343T1 (de) | 1997-06-15 |
ES2101689T3 (es) | 1997-07-16 |
JPH04503956A (ja) | 1992-07-16 |
DE69030745T2 (de) | 1997-09-11 |
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