ES2100051T3 - Sintesis de bloques dimeros y su uso en el ensamblaje de oligonucleotidos. - Google Patents

Sintesis de bloques dimeros y su uso en el ensamblaje de oligonucleotidos.

Info

Publication number
ES2100051T3
ES2100051T3 ES94906568T ES94906568T ES2100051T3 ES 2100051 T3 ES2100051 T3 ES 2100051T3 ES 94906568 T ES94906568 T ES 94906568T ES 94906568 T ES94906568 T ES 94906568T ES 2100051 T3 ES2100051 T3 ES 2100051T3
Authority
ES
Spain
Prior art keywords
dimer blocks
oligonucleotides
synthesis
assembly
blocks
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94906568T
Other languages
English (en)
Inventor
Jin-Yan Tang
Patricia L Iadarola
Sudhir Agrawal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aceragen Inc
Original Assignee
Hybridon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hybridon Inc filed Critical Hybridon Inc
Application granted granted Critical
Publication of ES2100051T3 publication Critical patent/ES2100051T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EN LA INVENCION SE PRESENTAN METODOS PARA LA SINTESIS DE BLOQUES DE DIMEROS (DERIVADOS DE DINUCLEOSIDOS QUE TIENE LOS ENLACES DE INTERNUCLEOSIDOS MODIFICADOS) UTILIZANDO TECNICAS QUIMICAS SIMPLIFICADAS, NUEVOS BLOQUES DE DIMEROS Y METODO PARA LA UTILIZACION DE BLOQUES DE DIMEROS PARA LA UNION DE OLIGONUCLEOTIDOS QUE TIENEN ENLACES DE INTERNUCLEOTIDOS MODIFICADOS.
ES94906568T 1993-01-08 1994-01-07 Sintesis de bloques dimeros y su uso en el ensamblaje de oligonucleotidos. Expired - Lifetime ES2100051T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US282393A 1993-01-08 1993-01-08

Publications (1)

Publication Number Publication Date
ES2100051T3 true ES2100051T3 (es) 1997-06-01

Family

ID=21702683

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94906568T Expired - Lifetime ES2100051T3 (es) 1993-01-08 1994-01-07 Sintesis de bloques dimeros y su uso en el ensamblaje de oligonucleotidos.

Country Status (13)

Country Link
EP (1) EP0678096B1 (es)
JP (1) JPH08507752A (es)
KR (1) KR960700262A (es)
CN (1) CN1122137A (es)
AT (1) ATE150464T1 (es)
CA (1) CA2153505A1 (es)
DE (1) DE69402177T2 (es)
DK (1) DK0678096T3 (es)
ES (1) ES2100051T3 (es)
FI (1) FI953363A0 (es)
GR (1) GR3023123T3 (es)
NZ (1) NZ261480A (es)
WO (1) WO1994015946A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087491A (en) * 1993-01-08 2000-07-11 Hybridon, Inc. Extremely high purity oligonucleotides and methods of synthesizing them using dimer blocks
AU5319396A (en) * 1995-03-23 1996-10-08 Hybridon, Inc. Thiono triester modified antisense oligodeoxynucleotide phosphorothioates
US5856464A (en) * 1995-06-07 1999-01-05 Lajolla Pharmaceutical Company Selective capping solution phase oligonucleotide synthesis
US6172217B1 (en) * 1996-12-27 2001-01-09 Isis Pharmaceuticals Inc. Method of synthesizing phosphorothioate oligonucleotides
US5760209A (en) * 1997-03-03 1998-06-02 Isis Pharmaceuticals, Inc. Protecting group for synthesizing oligonucleotide analogs
US5902881A (en) * 1997-03-03 1999-05-11 Isis Pharmaceuticals, Inc. Reagent useful for synthesizing sulfurized oligonucleotide analogs
GB9717158D0 (en) * 1997-08-13 1997-10-22 King S College London Solution synthesis of oligonucleotides and their phosphorothioate analogues
US6380378B1 (en) 1998-12-24 2002-04-30 Toagosei Company, Ltd. Nucleotide compound, nucleotide block oligonucleotide, and method for producing them
US6207819B1 (en) * 1999-02-12 2001-03-27 Isis Pharmaceuticals, Inc. Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
JP2003506566A (ja) 1999-06-25 2003-02-18 アカデミス ジーケンホイス ベイ デ ユニフェルジテイト ファン アムステルダム ラジカルをウロカニン酸、誘導体、及びアナログで除去する方法
CN102344477B (zh) * 2010-07-27 2015-04-08 苏州瑞博生物技术有限公司 一种核苷酸和/或寡核苷酸及其制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
DE3332068A1 (de) * 1983-09-06 1985-03-21 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von nukleosidalkyl-, aralkyl- und arylphosphoniten und -phosphonaten
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
FR2596761B1 (fr) * 1986-04-08 1988-05-20 Commissariat Energie Atomique Derives de nucleosides et leur utilisation pour la synthese d'oligonucleotides
US5194428A (en) * 1986-05-23 1993-03-16 Worcester Foundation For Experimental Biology Inhibition of influenza virus replication by oligonucleotide phosphorothioates
US5449769A (en) * 1989-03-06 1995-09-12 Gen-Probe Incorporated Method and reagent for sulfurization of organophosphorous compounds
US5003097A (en) * 1989-10-02 1991-03-26 The United States Of America As Represented By The Department Of Health And Human Services Method for the sulfurization of phosphorous groups in compounds
DK0942000T3 (da) * 1989-10-24 2004-11-01 Isis Pharmaceuticals Inc 2'-modificerede oligonukleotider
WO1992004358A1 (en) * 1990-09-04 1992-03-19 Gen-Probe Incorporated Method and reagent for sulfurization of organophosphorous compounds
WO1992020967A1 (en) * 1991-05-10 1992-11-26 Scholer Incineration Co Pty Ltd Incinerator
FI115214B (fi) * 1992-01-22 2005-03-31 Hoechst Ag Menetelmä oligonukleotidianalogien valmistamiseksi ja niiden käyttö
RU95104940A (ru) * 1992-07-27 1997-01-10 Хайбрайдон Способ введения в олигонуклеотид алкилфосфонотиоатной или арилфосфонотиоатной межнуклеотидной связи, способ получения олигонуклеотида, олигонуклеотиды, способ ингибирования генной экспрессии, способ лечения

Also Published As

Publication number Publication date
CN1122137A (zh) 1996-05-08
DK0678096T3 (da) 1997-08-18
ATE150464T1 (de) 1997-04-15
NZ261480A (en) 1997-05-26
DE69402177D1 (de) 1997-04-24
GR3023123T3 (en) 1997-07-30
AU673051B2 (en) 1996-10-24
AU6024394A (en) 1994-08-15
CA2153505A1 (en) 1994-07-21
EP0678096A1 (en) 1995-10-25
FI953363A (fi) 1995-07-07
DE69402177T2 (de) 1997-06-26
EP0678096B1 (en) 1997-03-19
JPH08507752A (ja) 1996-08-20
WO1994015946A1 (en) 1994-07-21
FI953363A0 (fi) 1995-07-07
KR960700262A (ko) 1996-01-19

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