ATE284409T1 - Synthese von sulfurierten oligonukleotiden - Google Patents

Synthese von sulfurierten oligonukleotiden

Info

Publication number
ATE284409T1
ATE284409T1 AT98953408T AT98953408T ATE284409T1 AT E284409 T1 ATE284409 T1 AT E284409T1 AT 98953408 T AT98953408 T AT 98953408T AT 98953408 T AT98953408 T AT 98953408T AT E284409 T1 ATE284409 T1 AT E284409T1
Authority
AT
Austria
Prior art keywords
oligonucleotides
sulfurated
synthesis
methods
formation
Prior art date
Application number
AT98953408T
Other languages
English (en)
Inventor
Douglas L Cole
Vasulinga T Ravikumar
Zacharia S Cheruvallath
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25490845&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE284409(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE284409T1 publication Critical patent/ATE284409T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
AT98953408T 1997-10-15 1998-10-13 Synthese von sulfurierten oligonukleotiden ATE284409T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/950,779 US6114519A (en) 1997-10-15 1997-10-15 Synthesis of sulfurized oligonucleotides
PCT/US1998/021502 WO1999019340A1 (en) 1997-10-15 1998-10-13 Improved synthesis of sulfurized oligonucleotides

Publications (1)

Publication Number Publication Date
ATE284409T1 true ATE284409T1 (de) 2004-12-15

Family

ID=25490845

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98953408T ATE284409T1 (de) 1997-10-15 1998-10-13 Synthese von sulfurierten oligonukleotiden

Country Status (8)

Country Link
US (1) US6114519A (de)
EP (1) EP1023310B2 (de)
AT (1) ATE284409T1 (de)
AU (1) AU1079499A (de)
DE (1) DE69828076T3 (de)
ES (1) ES2235372T5 (de)
PT (1) PT1023310E (de)
WO (1) WO1999019340A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4161997A (en) * 1996-08-30 1998-03-19 Hybridon, Inc. Novel sulfur transfer reagents for oligonucleotide synthesis
US6242591B1 (en) * 1997-10-15 2001-06-05 Isis Pharmaceuticals, Inc. Synthesis of sulfurized 2'-substituted oligonucleotides
WO2002081476A1 (en) * 2001-04-06 2002-10-17 Micrologix Biotech, Inc. Thiophosphate nucleic acid-based compounds
US7045319B2 (en) * 2001-10-30 2006-05-16 Ribomed Biotechnologies, Inc. Molecular detection systems utilizing reiterative oligonucleotide synthesis
US20040054162A1 (en) * 2001-10-30 2004-03-18 Hanna Michelle M. Molecular detection systems utilizing reiterative oligonucleotide synthesis
US20050214796A1 (en) * 2003-10-29 2005-09-29 Hanna Michelle M Compositions, methods and detection technologies for reiterative oligonucleotide synthesis
EP1692139B1 (de) 2003-11-13 2013-02-13 Isis Pharmaceuticals, Inc. 5,6-dihydroxy-isoindolderivate als linker für die festphasensynthese von oligomeren
CA2561741C (en) 2004-04-05 2016-09-27 Alnylam Pharmaceuticals, Inc. Processes and reagents for oligonucleotide synthesis and purification
US7427675B2 (en) * 2004-08-23 2008-09-23 Isis Pharmaceuticals, Inc. Compounds and methods for the characterization of oligonucleotides
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US8242243B2 (en) 2008-05-15 2012-08-14 Ribomed Biotechnologies, Inc. Methods and reagents for detecting CpG methylation with a methyl CpG binding protein (MBP)
WO2010009060A2 (en) * 2008-07-13 2010-01-21 Ribomed Biotechnologies, Inc. Molecular beacon-based methods for detection of targets using abscription
CN102421914A (zh) 2009-03-15 2012-04-18 里伯米德生物技术公司 基于流产转录的分子检测
US8309710B2 (en) 2009-06-29 2012-11-13 Agilent Technologies, Inc. Use of N-alkyl imidazole for sulfurization of oligonucleotides with an acetyl disulfide
US8642755B2 (en) * 2009-06-30 2014-02-04 Agilent Technologies, Inc. Use of thioacetic acid derivatives in the sulfurization of oligonucleotides with phenylacetyl disulfide
PT3286203T (pt) 2015-04-23 2020-07-08 Geron Corp Métodos de preparação de polinucleótidos com a utilização de composições de sal de catiões multivalentes

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3923763A (en) * 1972-09-15 1975-12-02 Petro Tex Chem Corp Novel sulfur compound modifiers for chloroprene polymerization
JPS5442617B2 (de) * 1974-12-28 1979-12-15
US4959463A (en) * 1985-10-15 1990-09-25 Genentech, Inc. Intermediates
NL8902521A (nl) * 1989-10-11 1991-05-01 Rijksuniversiteit Werkwijze voor het bereiden van fosforothioaatesters.
US5151510A (en) * 1990-04-20 1992-09-29 Applied Biosystems, Inc. Method of synethesizing sulfurized oligonucleotide analogs
GB9127243D0 (en) * 1991-12-23 1992-02-19 King S College London Synthesis of phosphorothioate analogues of oligonucleotides
US5574146A (en) † 1994-08-30 1996-11-12 Beckman Instruments, Inc. Oligonucleotide synthesis with substituted aryl carboxylic acids as activators
US6001555A (en) * 1994-09-23 1999-12-14 The United States Of America As Represented By The Department Of Health And Human Services Method for identifying and using compounds that inactivate HIV-1 and other retroviruses by attacking highly conserved zinc fingers in the viral nucleocapsid protein

Also Published As

Publication number Publication date
ES2235372T5 (es) 2014-06-23
ES2235372T3 (es) 2005-07-01
EP1023310A4 (de) 2001-05-16
DE69828076T3 (de) 2014-07-10
WO1999019340A1 (en) 1999-04-22
EP1023310B1 (de) 2004-12-08
DE69828076D1 (de) 2005-01-13
US6114519A (en) 2000-09-05
EP1023310A1 (de) 2000-08-02
EP1023310B2 (de) 2014-05-21
DE69828076T2 (de) 2005-11-24
PT1023310E (pt) 2005-02-28
AU1079499A (en) 1999-05-03

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Legal Events

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