ATE277068T1 - 2'-modifizierte oligonucleotide mit rns wirkung, die konformell eingeschränkt sind - Google Patents

2'-modifizierte oligonucleotide mit rns wirkung, die konformell eingeschränkt sind

Info

Publication number
ATE277068T1
ATE277068T1 AT99935814T AT99935814T ATE277068T1 AT E277068 T1 ATE277068 T1 AT E277068T1 AT 99935814 T AT99935814 T AT 99935814T AT 99935814 T AT99935814 T AT 99935814T AT E277068 T1 ATE277068 T1 AT E277068T1
Authority
AT
Austria
Prior art keywords
rns
conformally
restricted
action
modified oligonucleotides
Prior art date
Application number
AT99935814T
Other languages
English (en)
Inventor
Muthiah Manoharan
Venkatraman Mohan
Herb Boswell
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of ATE277068T1 publication Critical patent/ATE277068T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT99935814T 1998-07-27 1999-07-21 2'-modifizierte oligonucleotide mit rns wirkung, die konformell eingeschränkt sind ATE277068T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/123,108 US6271358B1 (en) 1998-07-27 1998-07-27 RNA targeted 2′-modified oligonucleotides that are conformationally preorganized
PCT/US1999/016541 WO2000006590A1 (en) 1998-07-27 1999-07-21 Rna targeted 2'-modified oligonucleotides that are conformationally preorganized

Publications (1)

Publication Number Publication Date
ATE277068T1 true ATE277068T1 (de) 2004-10-15

Family

ID=22406758

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99935814T ATE277068T1 (de) 1998-07-27 1999-07-21 2'-modifizierte oligonucleotide mit rns wirkung, die konformell eingeschränkt sind

Country Status (6)

Country Link
US (1) US6271358B1 (de)
EP (1) EP1100809B1 (de)
AT (1) ATE277068T1 (de)
AU (1) AU5121399A (de)
DE (1) DE69920477D1 (de)
WO (1) WO2000006590A1 (de)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6824976B1 (en) 1993-04-02 2004-11-30 Rigel Pharmaceuticals, Inc. Method for selective inactivation of viral replication
US6639061B1 (en) 1999-07-07 2003-10-28 Isis Pharmaceuticals, Inc. C3′-methylene hydrogen phosphonate oligomers and related compounds
US7812149B2 (en) 1996-06-06 2010-10-12 Isis Pharmaceuticals, Inc. 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
US9096636B2 (en) 1996-06-06 2015-08-04 Isis Pharmaceuticals, Inc. Chimeric oligomeric compounds and their use in gene modulation
US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
US6576752B1 (en) * 1997-02-14 2003-06-10 Isis Pharmaceuticals, Inc. Aminooxy functionalized oligomers
US6326478B1 (en) 1998-07-08 2001-12-04 Isis Pharmaceuticals, Inc. Process for the synthesis of oligomeric compounds
US6277967B1 (en) 1998-07-14 2001-08-21 Isis Pharmaceuticals, Inc. Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages
DE19956568A1 (de) * 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
US6465628B1 (en) 1999-02-04 2002-10-15 Isis Pharmaceuticals, Inc. Process for the synthesis of oligomeric compounds
US20040082774A1 (en) * 1999-03-16 2004-04-29 Guzaev Andrei P. Novel phosphate and thiophosphate protecting groups
US6121437A (en) * 1999-03-16 2000-09-19 Isis Pharmaceuticals, Inc. Phosphate and thiophosphate protecting groups
US6610842B1 (en) * 1999-05-06 2003-08-26 Isis Pharmaceuticals, Inc. Processes for the synthesis of oligomers using phosphoramidite compositions
US6656730B1 (en) 1999-06-15 2003-12-02 Isis Pharmaceuticals, Inc. Oligonucleotides conjugated to protein-binding drugs
US6593466B1 (en) * 1999-07-07 2003-07-15 Isis Pharmaceuticals, Inc. Guanidinium functionalized nucleotides and precursors thereof
US6617442B1 (en) * 1999-09-30 2003-09-09 Isis Pharmaceuticals, Inc. Human Rnase H1 and oligonucleotide compositions thereof
DE10100586C1 (de) * 2001-01-09 2002-04-11 Ribopharma Ag Verfahren zur Hemmung der Expression eines Ziegens
US7423142B2 (en) * 2001-01-09 2008-09-09 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US7767802B2 (en) * 2001-01-09 2010-08-03 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of anti-apoptotic genes
US7169916B2 (en) * 2002-04-01 2007-01-30 Isis Pharmaceuticals, Inc. Chloral-free DCA in oligonucleotide synthesis
WO2004044136A2 (en) 2002-11-05 2004-05-27 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2’-modified nucleosides for use in gene modulation
US9150606B2 (en) 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
US9150605B2 (en) * 2002-11-05 2015-10-06 Isis Pharmaceuticals, Inc. Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
US7002006B2 (en) * 2003-02-12 2006-02-21 Isis Pharmaceuticals, Inc. Protection of nucleosides
BRPI0410886A (pt) 2003-06-03 2006-07-04 Isis Pharmaceuticals Inc composto de filamento duplo, composição farmacêutica, sal farmaceuticamente aceitável, métodos de modificação do ácido nucleico que codifica a survivina humana, de inibição da expressão da suvivina em células ou tecidos, e de tratamento de uma condição associada com a expressão ou superexpressão da suvivina, e, oligonucleotìdeo de rnai de filamento único
DK3604537T3 (da) 2003-06-13 2022-02-28 Alnylam Europe Ag Dobbeltstrenget ribonukleinsyre med forøget effektivitet i en organisme
US8569474B2 (en) 2004-03-09 2013-10-29 Isis Pharmaceuticals, Inc. Double stranded constructs comprising one or more short strands hybridized to a longer strand
KR101147147B1 (ko) 2004-04-01 2012-05-25 머크 샤프 앤드 돔 코포레이션 Ｒｎａ 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
WO2005097817A2 (en) 2004-04-05 2005-10-20 Alnylam Pharmaceuticals, Inc. Process and reagents for oligonucleotide synthesis and purification
EP1750776A2 (de) 2004-04-30 2007-02-14 Alnylam Pharmaceuticals Inc. Oligonukleotide mit c5-modifiziertem pyrimidin
US8394947B2 (en) 2004-06-03 2013-03-12 Isis Pharmaceuticals, Inc. Positionally modified siRNA constructs
WO2006023880A2 (en) * 2004-08-23 2006-03-02 Isis Pharmaceuticals, Inc. Compounds and methods for the characterization of oligonucleotides
US7884086B2 (en) 2004-09-08 2011-02-08 Isis Pharmaceuticals, Inc. Conjugates for use in hepatocyte free uptake assays
US7935811B2 (en) 2004-11-22 2011-05-03 Dharmacon, Inc. Apparatus and system having dry gene silencing compositions
US7923206B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Method of determining a cellular response to a biological agent
US7923207B2 (en) 2004-11-22 2011-04-12 Dharmacon, Inc. Apparatus and system having dry gene silencing pools
WO2007027775A2 (en) 2005-08-29 2007-03-08 Isis Pharmaceuticals, Inc. Methods for use in modulating mir-122a
DK1931780T3 (en) 2005-08-29 2016-01-25 Regulus Therapeutics Inc Antisense-forbindelser med forøget anti-microrna-aktivitet
US7320965B2 (en) * 2005-10-28 2008-01-22 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of Huntingtin gene
CA2626584A1 (en) * 2005-11-04 2007-05-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of nav1.8 gene
WO2007056331A2 (en) 2005-11-09 2007-05-18 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of factor v leiden mutant gene
JP5213723B2 (ja) 2006-01-27 2013-06-19 アイシス ファーマシューティカルズ， インコーポレーテッド マイクロｒｎａの調節に使用するためのオリゴマー化合物及び組成物
CA2663601C (en) 2006-09-22 2014-11-25 Dharmacon, Inc. Duplex oligonucleotide complexes and methods for gene silencing by rna interference
CN104975020B (zh) 2008-02-11 2020-01-17 菲奥医药公司 经修饰的RNAi多核苷酸及其用途
US8188060B2 (en) 2008-02-11 2012-05-29 Dharmacon, Inc. Duplex oligonucleotides with enhanced functionality in gene regulation
EP2274423A2 (de) * 2008-04-04 2011-01-19 Isis Pharmaceuticals, Inc. Bicyclische nukleoside umfassende oligomere verbindungen mit verringerter toxizität
JP2011527893A (ja) * 2008-07-15 2011-11-10 エフ．ホフマン−ラ ロシュ アーゲー ＴＧＦ−β受容体遺伝子の発現を阻害するための組成物および方法
WO2010008582A2 (en) 2008-07-18 2010-01-21 Rxi Pharmaceuticals Corporation Phagocytic cell drug delivery system
EP2949752B1 (de) 2008-09-22 2017-12-20 RXi Pharmaceuticals Corporation Selbstfreisetzende rnai-verbindungen von reduzierter grösse
WO2010048585A2 (en) 2008-10-24 2010-04-29 Isis Pharmaceuticals, Inc. Oligomeric compounds and methods
SG171737A1 (en) * 2008-11-17 2011-07-28 Hoffmann La Roche Compositions and methods for inhibiting expression of factor vii genes
US9074211B2 (en) 2008-11-19 2015-07-07 Rxi Pharmaceuticals Corporation Inhibition of MAP4K4 through RNAI
WO2010078536A1 (en) 2009-01-05 2010-07-08 Rxi Pharmaceuticals Corporation Inhibition of pcsk9 through rnai
MX2011007776A (es) 2009-02-03 2011-08-12 Hoffmann La Roche Compsiciones y metodos para inhibir la expresion de genes ptp1b.
WO2010090762A1 (en) 2009-02-04 2010-08-12 Rxi Pharmaceuticals Corporation Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
WO2010091308A2 (en) 2009-02-06 2010-08-12 Isis Pharmaceuticals, Inc. Oligomeric compounds and methods
TW201102091A (en) * 2009-05-15 2011-01-16 Hoffmann La Roche Compositions and methods for inhibiting expression of glucocorticoid receptor (GCR) genes
AR078921A1 (es) * 2009-11-09 2011-12-14 Hoffmann La Roche Composiciones y metodos para inhibir la expresion de genes de la superfamilia de quinesinas, kif10
US20110152349A1 (en) 2009-12-18 2011-06-23 Anke Geick Compositions and methods for inhibiting expression of il-18 genes
TW201129365A (en) * 2010-02-05 2011-09-01 Hoffmann La Roche Compositions and methods for inhibiting expression of IKK2 genes
EP3578183B1 (de) 2010-03-24 2021-09-08 Phio Pharmaceuticals Corp. Rna-interferenz bei augenerkrankungen
RU2615143C2 (ru) 2010-03-24 2017-04-04 Адвирна Самодоставляющие PHKi соединения уменьшенного размера
WO2011119887A1 (en) 2010-03-24 2011-09-29 Rxi Pharmaceuticals Corporation Rna interference in dermal and fibrotic indications
EP3434772A3 (de) 2010-10-18 2019-03-20 Arrowhead Pharmaceuticals, Inc. Zusammensetzungen und verfahren zur hemmung der expression von rrm2-genen
MX342731B (es) 2011-06-30 2016-10-11 Arrowhead Res Corp Composiciones y metodos para inhibir la expresion genica del virus de hepatitis b.
EP3052464B1 (de) 2013-10-04 2020-04-15 Novartis AG 3 endkappen für rnai-mittel zur verwendung in der rna-interferenz
US9988627B2 (en) 2013-10-04 2018-06-05 Novartis Ag Formats for organic compounds for use in RNA interference
JP6546161B2 (ja) 2013-10-04 2019-07-17 ノバルティス アーゲー Ｂ型肝炎ウイルスを治療するための有機化合物
EP3079707A4 (de) 2013-12-02 2017-10-18 RXi Pharmaceuticals Corporation Immuntherapie für krebs
CA2947270A1 (en) 2014-04-28 2015-11-05 Rxi Pharmaceuticals Corporation Methods for treating cancer using nucleic acids targeting mdm2 or mycn
TW201620526A (zh) 2014-06-17 2016-06-16 愛羅海德研究公司 用於抑制α－１抗胰蛋白酶基因表現之組合物及方法
US10900039B2 (en) 2014-09-05 2021-01-26 Phio Pharmaceuticals Corp. Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
JP6983752B2 (ja) 2015-07-06 2021-12-17 フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. スーパーオキシドディスムターゼ１（ｓｏｄ１）を標的とする核酸分子
US10808247B2 (en) 2015-07-06 2020-10-20 Phio Pharmaceuticals Corp. Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
KR20180038465A (ko) 2015-08-07 2018-04-16 애로우헤드 파마슈티컬스 인코포레이티드 Ｂ형 간염 바이러스 감염에 대한 ｒｎａｉ 치료법
WO2017070151A1 (en) 2015-10-19 2017-04-27 Rxi Pharmaceuticals Corporation Reduced size self-delivering nucleic acid compounds targeting long non-coding rna
US20190247436A1 (en) 2016-07-21 2019-08-15 Maxcyte, Inc. Methods and compositions for modifying genomic dna
JOP20170161A1 (ar) 2016-08-04 2019-01-30 Arrowhead Pharmaceuticals Inc عوامل RNAi للعدوى بفيروس التهاب الكبد ب
JOP20180003B1 (ar) 2017-01-10 2022-09-15 Arrowhead Pharmaceuticals Inc عوامل RNAi ألفا-1 مضادة للتريبسين (AAT)، وتركيبات تتضمن عوامل AAT RNAi، وطرق الاستخدام
KR20210018267A (ko) 2018-05-07 2021-02-17 알닐람 파마슈티칼스 인코포레이티드 간외 전달
AU2020297008A1 (en) 2019-06-18 2022-02-17 Janssen Sciences Ireland Unlimited Company Combination of hepatitis B virus (HBV) vaccines and HBV-targeting RNAi
EP3986562A1 (de) 2019-06-18 2022-04-27 Janssen Sciences Ireland Unlimited Company Kombination von hepatitis-b-virus(hbv)-impfstoffen und auf hbv abzielender rnai
WO2023233290A1 (en) 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Rnai agents targeting pd-l1
WO2024097674A2 (en) * 2022-11-02 2024-05-10 Aligos Therapeutics, Inc. Modified short interfering nucleic acid (sina) molecules and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
GB8607265D0 (en) * 1986-03-24 1986-04-30 London King S College Protecting groups of organic synthesis
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
EP0392000A4 (en) * 1988-10-10 1991-12-18 G.D. Engineering Pty Limited Pre-stretching wrapping film
US5109126A (en) * 1988-12-06 1992-04-28 Worcester Foundation For Experimental Biology 5'[2'(3')-O-(2,4,6-trinitrophenyl) pyprimidine nucleoside]diphosphate 1-glycosides
US5212295A (en) 1990-01-11 1993-05-18 Isis Pharmaceuticals Monomers for preparation of oligonucleotides having chiral phosphorus linkages
US6369209B1 (en) * 1999-05-03 2002-04-09 Isis Pharmaceuticals, Inc. Oligonucleotides having A-DNA form and B-DNA form conformational geometry
US5438130A (en) * 1993-01-15 1995-08-01 Cambridge Neuroscience, Inc. Fucosylated guanosine disulfates as excitatory amino acid antagonists
US5858988A (en) * 1993-02-24 1999-01-12 Wang; Jui H. Poly-substituted-phenyl-oligoribo nucleotides having enhanced stability and membrane permeability and methods of use
CN1078478C (zh) * 1993-02-24 2002-01-30 王瑞駪 活性抗病毒聚合物的组成及应用方法

Also Published As

Publication number Publication date
US6271358B1 (en) 2001-08-07
WO2000006590A1 (en) 2000-02-10
AU5121399A (en) 2000-02-21
EP1100809A4 (de) 2002-02-27
EP1100809A1 (de) 2001-05-23
DE69920477D1 (de) 2004-10-28
EP1100809B1 (de) 2004-09-22

Similar Documents

Publication Publication Date Title
ATE277068T1 (de) 2'-modifizierte oligonucleotide mit rns wirkung, die konformell eingeschränkt sind
DE69806003T2 (de) Dna polymerasen, die verbesserte fähigkeiten zum einbau markierter nukleotide besitzen
EP1102787A4 (de) 2'-o-aminoethyloxyethyl-modifizierte oligonukleotide
DK0691980T3 (da) 7-deazapurinmodifiderende oligonukleotider
WO2005026184A3 (en) Synthesis and compositions of 2'-terminator nucleotides
CA2153898A1 (en) Method for generating single-stranded dna molecules
DK1178999T3 (da) L-RIBO-LNA-analoger
ATE373671T1 (de) Aminooxy-modifizierte oligonukleotide
ATE225369T1 (de) Doppelsträngige peptidenukleinsäuren
CA2167361A1 (en) 2,2-difluoro-3-carbamoyl ribose sulfonate compounds and process for the preparation of beta nucleosides
ATE342911T1 (de) Synthese von nukleosiden und polynukleotiden
BR9401355A (pt) Oligonucleotídeo e nucleotídeo.
WO1996006949A3 (en) Nucleic acid hybridization assay probes targeted to mycoplasma pneumoniae nucleic acid
ZA9811833B (en) Pharmaceutical compositions of uridine triphosphate.
BR9808730B1 (pt) processo de preparação de 1,1,1,3,3-pentaclorobutano.
WO2000029623A3 (en) Nucleic acids containing single nucleotide polymorphisms and methods of use thereof
ATE284409T1 (de) Synthese von sulfurierten oligonukleotiden
EP0749439A4 (de) Nukleotid- oder nukleosid-fotoaffinitäts-verbindungen modifizierte antikörper, methoden ihrer herstellung und verwendung
DE69936774D1 (de) Strukturproteine des virus, welches die pankreas-krankheit bei fischen verursacht, und ihre verwendungen
CA2227491A1 (en) In situ preparation of nucleoside phosphoramidites and oligonucleotide synthesis
DE69726276D1 (de) In situ herstellung von nukleosid-phosphoramiditen und ihre verwendung in der oligonukleotidsynthese
IT1299990B1 (it) Lucchetto di sicurezza privo dell'arco di collegamento.
WO2001058914A3 (en) Haplotypes of the interleukin 15 gene
ES1031001Y (es) Abridor multiuso.
FR2721617B1 (fr) Fragments d'acides nucléiques, dérivés du génome de Mycobacterium xenopi et leurs applications.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties