DE60141895D1 - Substituierte beta-carboline mit ikb-kinase hemmender wirkung - Google Patents

Substituierte beta-carboline mit ikb-kinase hemmender wirkung

Info

Publication number
DE60141895D1
DE60141895D1 DE60141895T DE60141895T DE60141895D1 DE 60141895 D1 DE60141895 D1 DE 60141895D1 DE 60141895 T DE60141895 T DE 60141895T DE 60141895 T DE60141895 T DE 60141895T DE 60141895 D1 DE60141895 D1 DE 60141895D1
Authority
DE
Germany
Prior art keywords
kinase
hemmender
ikb
carboline
effect
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60141895T
Other languages
German (de)
English (en)
Inventor
Olaf Ritzeler
Alfredo Castro
Louis Grenier
Francois Soucy
Wayne W Hancock
Hormoz Mazdiyasni
Vito Palombella
Julian Adams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Sanofi Aventis Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP00105514A external-priority patent/EP1134221A1/en
Priority claimed from EP00125169A external-priority patent/EP1209158A1/en
Application filed by Sanofi Aventis Deutschland GmbH filed Critical Sanofi Aventis Deutschland GmbH
Priority claimed from PCT/EP2001/002237 external-priority patent/WO2001068648A1/en
Application granted granted Critical
Publication of DE60141895D1 publication Critical patent/DE60141895D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
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  • Communicable Diseases (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
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  • Obesity (AREA)
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  • Biotechnology (AREA)
  • Hospice & Palliative Care (AREA)
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DE60141895T 2000-03-15 2001-02-28 Substituierte beta-carboline mit ikb-kinase hemmender wirkung Expired - Lifetime DE60141895D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00105514A EP1134221A1 (en) 2000-03-15 2000-03-15 Substituted beta-carbolines as lkB kinase inhibitors
EP00125169A EP1209158A1 (en) 2000-11-18 2000-11-18 Substituted beta-carbolines
PCT/EP2001/002237 WO2001068648A1 (en) 2000-03-15 2001-02-28 Substituted beta-carbolines with ikb-kinase inhibiting activity

Publications (1)

Publication Number Publication Date
DE60141895D1 true DE60141895D1 (de) 2010-06-02

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DE60141895T Expired - Lifetime DE60141895D1 (de) 2000-03-15 2001-02-28 Substituierte beta-carboline mit ikb-kinase hemmender wirkung

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US (3) US6627637B2 (enExample)
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KR (1) KR100826817B1 (enExample)
CN (1) CN100509810C (enExample)
AT (1) ATE465161T1 (enExample)
AU (2) AU2001237418B2 (enExample)
BR (1) BR0109161A (enExample)
CA (1) CA2402549A1 (enExample)
CZ (1) CZ301077B6 (enExample)
DE (1) DE60141895D1 (enExample)
EE (1) EE200200523A (enExample)
HK (1) HK1054039B (enExample)
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IL (2) IL151695A0 (enExample)
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Families Citing this family (49)

* Cited by examiner, † Cited by third party
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JP5000828B2 (ja) * 2000-03-15 2012-08-15 サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング ＩｋＢキナーゼ阻害活性を有する置換ベーターカルボリン
EP1363993A4 (en) * 2001-02-01 2008-11-12 Bristol Myers Squibb Co METHOD FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES USING I KAPPA B KINASE (IKK)
EP1443927B1 (en) * 2001-11-07 2007-01-10 Millennium Pharmaceuticals, Inc. Carboline derivatives as inhibitors of ikb in the treatment of multiple myeloma
US7462638B2 (en) * 2002-08-17 2008-12-09 Sanofi-Aventis Deutschland Gmbh Use of IκB-kinase inhibitors in pain therapy
US20040166095A1 (en) * 2003-02-25 2004-08-26 Blazar Bruce R. Methods for preventing GVHD
AU2004230952A1 (en) * 2003-04-09 2004-10-28 Millenium Pharmaceuticals, Inc. Beta-carbolines useful for treating inflammatory disease
DE602005020263D1 (de) * 2004-04-09 2010-05-12 Millennium Pharm Inc Für die behandlung von entzündlichen krankheiten nützliche beta-carboline
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