DE60131160T2 - Caspase-inhibitoren und ihre verwendungen - Google Patents

Caspase-inhibitoren und ihre verwendungen Download PDF

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Publication number
DE60131160T2
DE60131160T2 DE60131160T DE60131160T DE60131160T2 DE 60131160 T2 DE60131160 T2 DE 60131160T2 DE 60131160 T DE60131160 T DE 60131160T DE 60131160 T DE60131160 T DE 60131160T DE 60131160 T2 DE60131160 T2 DE 60131160T2
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disease
compound according
treatment
caspase
compound
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DE60131160T
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DE60131160D1 (de
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Jean-Damien Vertex Pharmaceuticals I Charrier
Guy Vertex Pharmaceuticals Ltd. Oxon BRENCHLEY
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Public Health (AREA)
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  • Neurology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
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  • Hospice & Palliative Care (AREA)
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DE60131160T 2000-06-07 2001-06-05 Caspase-inhibitoren und ihre verwendungen Expired - Lifetime DE60131160T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US20992900P 2000-06-07 2000-06-07
US209929P 2000-06-07
PCT/US2001/018243 WO2001094351A1 (en) 2000-06-07 2001-06-05 Caspase inhibitors and uses thereof

Publications (2)

Publication Number Publication Date
DE60131160D1 DE60131160D1 (de) 2007-12-13
DE60131160T2 true DE60131160T2 (de) 2008-08-07

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DE60131160T Expired - Lifetime DE60131160T2 (de) 2000-06-07 2001-06-05 Caspase-inhibitoren und ihre verwendungen

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US (3) US7407964B2 (enExample)
EP (1) EP1289993B9 (enExample)
JP (1) JP2003535865A (enExample)
KR (1) KR20030025235A (enExample)
AT (1) ATE377010T1 (enExample)
AU (2) AU2001275279B2 (enExample)
CA (1) CA2409015A1 (enExample)
DE (1) DE60131160T2 (enExample)
ES (1) ES2295171T3 (enExample)
IL (1) IL152845A0 (enExample)
WO (1) WO2001094351A1 (enExample)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4213500A (en) 1999-04-09 2000-11-14 Cytovia, Inc. Caspase inhibitors and the use thereof
DK1163208T3 (da) 1999-08-06 2004-08-16 Vertex Pharma Caspaseinhibitorer og anvendelser deraf
BR0013666A (pt) 1999-08-27 2002-05-14 Cytovia Inc "alfa"-hidróxi-ácidos substituìdos inibidores de caspases e o seu uso
PE20011350A1 (es) 2000-05-19 2002-01-15 Vertex Pharma PROFARMACO DE UN INHIBIDOR DE ENZIMA CONVERTIDORA DE INTERLEUCINA-1ß (ICE)
AU2001275279B2 (en) * 2000-06-07 2007-01-04 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
WO2003068242A1 (en) 2002-02-11 2003-08-21 Vertex Pharmaceuticals Incorporated Phospholipids as caspase inhibitor prodrugs
US7960398B2 (en) 2002-04-19 2011-06-14 Vertex Pharmaceuticals Incorporated Regulation of TNF-alpha
PL374598A1 (en) 2002-06-28 2005-10-31 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
CN100366612C (zh) * 2002-12-20 2008-02-06 沃泰克斯药物股份有限公司 4-氧代-3-(1-氧代-1h-异喹啉-2-基乙酰氨基)-戊酸酯和酰胺衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途
AU2003292436B2 (en) * 2002-12-27 2009-07-30 Msd Italia S.R.L. Tetrahydro-4H-pyrido[1,2-A]pyrimidines and related compounds useful as HIV integrase inhibitors
US20060217299A1 (en) * 2003-02-24 2006-09-28 Hirofumi Doi Degradation inhibitor for hepatitis b virus x interacting protein
PE20050159A1 (es) 2003-05-27 2005-04-19 Vertex Pharma Derivados de acido 3-[2-(3-amino-2-oxo-2h-piridin-1-il)-acetilamino]-4-oxo-pentanoico como inhibidores de caspasa
IL158599A0 (en) * 2003-10-26 2004-05-12 Yeda Res & Dev Methods of modulating hematopoiesis
WO2005117846A2 (en) 2004-05-27 2005-12-15 Vertex Pharmaceuticals Incorporated Ice inhibitors for the treatment of autoinflammatory diseases
EP1718639A2 (en) 2004-02-27 2006-11-08 Vertex Pharmaceuticals Incorporated Caspase inhibitors and uses thereof
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ES2295171T3 (es) 2008-04-16
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US7407964B2 (en) 2008-08-05
US20020045623A1 (en) 2002-04-18
US7968716B2 (en) 2011-06-28
AU2001275279B2 (en) 2007-01-04
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US20110003824A1 (en) 2011-01-06
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