ES2295171T3 - Inhibidores de caspasa y sus usos. - Google Patents
Inhibidores de caspasa y sus usos. Download PDFInfo
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- ES2295171T3 ES2295171T3 ES01941972T ES01941972T ES2295171T3 ES 2295171 T3 ES2295171 T3 ES 2295171T3 ES 01941972 T ES01941972 T ES 01941972T ES 01941972 T ES01941972 T ES 01941972T ES 2295171 T3 ES2295171 T3 ES 2295171T3
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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| US7960398B2 (en) | 2002-04-19 | 2011-06-14 | Vertex Pharmaceuticals Incorporated | Regulation of TNF-alpha |
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| CN100366612C (zh) * | 2002-12-20 | 2008-02-06 | 沃泰克斯药物股份有限公司 | 4-氧代-3-(1-氧代-1h-异喹啉-2-基乙酰氨基)-戊酸酯和酰胺衍生物及其作为天冬氨酸特异性半胱氨酸蛋白酶抑制剂的用途 |
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| EP1718639A2 (en) | 2004-02-27 | 2006-11-08 | Vertex Pharmaceuticals Incorporated | Caspase inhibitors and uses thereof |
| CA2768700C (en) * | 2004-03-12 | 2014-04-29 | Vertex Pharmaceuticals Incorporated | Processes and intermediates for the preparation of aspartic acetal caspase inhibitors |
| US20060128696A1 (en) * | 2004-05-15 | 2006-06-15 | Annamaria Vezzani | Treating seizures using ice inhibitors |
| CA2580643C (en) * | 2004-09-17 | 2018-06-12 | Biomas, Ltd. | Use of tellurium compounds for inhibition of interleukin-converting enzyme |
| ATE529430T1 (de) * | 2005-07-28 | 2011-11-15 | Vertex Pharma | Caspase-hemmer-propharmaka |
| KR20080083672A (ko) * | 2005-12-22 | 2008-09-18 | 쉐링 코포레이션 | 트롬빈 수용체 길항제로서 옥사졸로이소퀴놀린 유도체 |
| WO2009140765A1 (en) | 2008-05-21 | 2009-11-26 | New World Laboratories Inc. | Selective caspase inhibitors and uses thereof |
| WO2010017408A1 (en) | 2008-08-06 | 2010-02-11 | The Buck Institute For Age Research | Caspase inhibitors and uses thereof |
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| CN101580505B (zh) * | 2009-05-27 | 2014-09-10 | 沈阳药科大学 | 吡咯并[2，1-b]喹唑啉类天然产物的衍生物及其制备方法和用途 |
| WO2011094426A1 (en) | 2010-01-29 | 2011-08-04 | The United State Of America, As Represented By The Secretary, Department Of Health & Human Services | Caspase inhibitors |
| JP6006908B2 (ja) | 2010-11-05 | 2016-10-12 | ブランダイス ユニバーシティＢｒａｎｄｅｉｓ Ｕｎｉｖｅｒｓｉｔｙ | Ｉｃｅ阻害化合物およびその使用 |
| WO2012140500A1 (en) | 2011-04-15 | 2012-10-18 | New World Laboratories, Inc. | Selective cysteine protease inhibitors and uses thereof |
| US9956260B1 (en) | 2011-07-22 | 2018-05-01 | The J. David Gladstone Institutes | Treatment of HIV-1 infection and AIDS |
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| WO2017079566A1 (en) | 2015-11-05 | 2017-05-11 | Conatus Pharmaceuticals, Inc. | Caspase inhibitors for use in the treatment of liver cancer |
| US20190022043A1 (en) | 2015-12-31 | 2019-01-24 | Conatus Pharmaceuticals Inc. | Methods of using caspase inhibitors in treatment of liver disease |
| WO2018065902A1 (en) | 2016-10-05 | 2018-04-12 | Novartis Ag | Combination compositions comprising fxr agonists for treating or preventing a fibrotic,cirrhotic disease or disorder |
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- 2001-06-05 AU AU7527901A patent/AU7527901A/xx active Pending
- 2001-06-05 IL IL15284501A patent/IL152845A0/xx unknown
- 2001-06-05 KR KR1020027016636A patent/KR20030025235A/ko not_active Withdrawn
- 2001-06-05 DE DE60131160T patent/DE60131160T2/de not_active Expired - Lifetime
- 2001-06-07 US US09/877,832 patent/US7407964B2/en not_active Expired - Fee Related
-
2008
- 2008-07-01 US US12/165,952 patent/US7829561B2/en not_active Expired - Fee Related
-
2010
- 2010-09-16 US US12/883,424 patent/US7968716B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003535865A (ja) | 2003-12-02 |
| US7829561B2 (en) | 2010-11-09 |
| AU7527901A (en) | 2001-12-17 |
| ATE377010T1 (de) | 2007-11-15 |
| EP1289993B1 (en) | 2007-10-31 |
| DE60131160T2 (de) | 2008-08-07 |
| KR20030025235A (ko) | 2003-03-28 |
| DE60131160D1 (de) | 2007-12-13 |
| EP1289993B9 (en) | 2008-08-20 |
| EP1289993A1 (en) | 2003-03-12 |
| CA2409015A1 (en) | 2001-12-13 |
| IL152845A0 (en) | 2003-06-24 |
| US7407964B2 (en) | 2008-08-05 |
| US20020045623A1 (en) | 2002-04-18 |
| US7968716B2 (en) | 2011-06-28 |
| AU2001275279B2 (en) | 2007-01-04 |
| US20090023739A1 (en) | 2009-01-22 |
| US20110003824A1 (en) | 2011-01-06 |
| WO2001094351A1 (en) | 2001-12-13 |
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