DE60039589D1 - Rekombinante il-18 antikörper und deren verwendung - Google Patents

Rekombinante il-18 antikörper und deren verwendung

Info

Publication number
DE60039589D1
DE60039589D1 DE60039589T DE60039589T DE60039589D1 DE 60039589 D1 DE60039589 D1 DE 60039589D1 DE 60039589 T DE60039589 T DE 60039589T DE 60039589 T DE60039589 T DE 60039589T DE 60039589 D1 DE60039589 D1 DE 60039589D1
Authority
DE
Germany
Prior art keywords
recombinant
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60039589T
Other languages
English (en)
Inventor
Yen Sen Ho
Stephen D Holmes
Alexander H Taylor
Sherin S Abdel-Meguid
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Ltd
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Ltd, SmithKline Beecham Corp filed Critical SmithKline Beecham Ltd
Application granted granted Critical
Publication of DE60039589D1 publication Critical patent/DE60039589D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Emergency Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE60039589T 1999-03-19 2000-03-17 Rekombinante il-18 antikörper und deren verwendung Expired - Lifetime DE60039589D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12529999P 1999-03-19 1999-03-19
PCT/US2000/007349 WO2000056771A1 (en) 1999-03-19 2000-03-17 Recombinant il-18 antagonists useful in treatment of il-18 mediated disorders

Publications (1)

Publication Number Publication Date
DE60039589D1 true DE60039589D1 (de) 2008-09-04

Family

ID=22419067

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60039589T Expired - Lifetime DE60039589D1 (de) 1999-03-19 2000-03-17 Rekombinante il-18 antikörper und deren verwendung

Country Status (28)

Country Link
US (2) US6706487B1 (de)
EP (2) EP1961768A1 (de)
JP (1) JP2002542769A (de)
KR (1) KR100697120B1 (de)
CN (1) CN1246335C (de)
AR (1) AR022952A1 (de)
AT (1) ATE402191T1 (de)
AU (1) AU764622B2 (de)
BR (1) BR0008688A (de)
CA (1) CA2368965C (de)
CO (1) CO5470287A1 (de)
CY (1) CY1108387T1 (de)
CZ (1) CZ303704B6 (de)
DE (1) DE60039589D1 (de)
DK (1) DK1163271T3 (de)
ES (1) ES2308974T3 (de)
HK (1) HK1043798B (de)
HU (1) HU228931B1 (de)
IL (1) IL144995A0 (de)
MY (1) MY124219A (de)
NO (1) NO330391B1 (de)
NZ (1) NZ513699A (de)
PL (1) PL202396B1 (de)
PT (1) PT1163271E (de)
SI (1) SI1163271T1 (de)
TR (3) TR200102733T2 (de)
WO (1) WO2000056771A1 (de)
ZA (1) ZA200107639B (de)

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IL121860A0 (en) 1997-08-14 1998-02-22 Yeda Res & Dev Interleukin-18 binding proteins their preparation and use
US7704944B2 (en) 1997-08-14 2010-04-27 Yeda Research And Development Company Ltd. Interleukin-18 binding proteins, their preparation and use for the treatment of sepsis
CA2276216A1 (en) * 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
AR022952A1 (es) * 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL
US7229619B1 (en) 2000-11-28 2007-06-12 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
EP1265928B1 (de) * 2000-01-27 2010-07-21 Medimmune, LLC Rsv neutralisierende antikörper mit sehr hohen affinität
CA2399148A1 (en) 2000-02-10 2001-08-16 Abbott Laboratories Antibodies that bind human interleukin-18 and methods of making and using
PT1257292E (pt) * 2000-02-21 2011-07-05 Yeda Res & Dev Utilização de inibidores de il-18
AU2002224417A1 (en) * 2000-10-18 2002-04-29 Immunex Corporation Methods for treating il-18 mediated disorders
US7179900B2 (en) 2000-11-28 2007-02-20 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
US20040018195A1 (en) * 2002-03-26 2004-01-29 Griswold Don Edgar Diabetes-related immunoglobulin derived proteins, compositions, methods and uses
US7132100B2 (en) 2002-06-14 2006-11-07 Medimmune, Inc. Stabilized liquid anti-RSV antibody formulations
WO2004040969A1 (ja) * 2002-11-07 2004-05-21 Kumamoto Technology & Industry Foundation Ｇａｎｐ導入トランスジェニック哺乳動物及びその利用
KR100988129B1 (ko) 2003-04-30 2010-10-18 쥬리디컬 파운데이션 더 케모-세로-쎄라퓨틱 리서치 인스티튜트 인간 항인간 인터루킨-18 항체와 그 단편, 및 이들의이용방법
US7968684B2 (en) * 2003-11-12 2011-06-28 Abbott Laboratories IL-18 binding proteins
AU2011224023C1 (en) * 2003-11-12 2013-08-29 Abbvie Inc. IL-18 binding proteins
US20050100965A1 (en) * 2003-11-12 2005-05-12 Tariq Ghayur IL-18 binding proteins
US7141382B1 (en) 2004-10-12 2006-11-28 Parikh Chirag R Methods for detection of IL-18 as an early marker for diagnosis of acute renal failure and predictor of mortality
MY144906A (en) 2005-10-21 2011-11-30 Novartis Ag Human antibodies against il13 and therapeutic uses
GB0610438D0 (en) * 2006-05-25 2006-07-05 Glaxo Group Ltd Immunoglobulins
US8133978B2 (en) 2006-05-25 2012-03-13 Glaxo Group Limited Humanised anti-interleukin-18 antibody
EP1997830A1 (de) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV-spezifische Bindemoleküle und Mittel zu ihrer Herstellung
US8048420B2 (en) 2007-06-12 2011-11-01 Ac Immune S.A. Monoclonal antibody
US8613923B2 (en) 2007-06-12 2013-12-24 Ac Immune S.A. Monoclonal antibody
CN101883790B (zh) 2007-10-05 2015-09-09 基因技术公司 抗淀粉样蛋白β抗体在眼病中的用途
US20100291071A1 (en) * 2008-08-01 2010-11-18 Immunas Pharma, Inc. Antibody Specific Binding to A-Beta Oligomer and the Use
AU2008312802A1 (en) * 2007-10-19 2009-04-23 Immunas Pharma, Inc. Antibody capable of specifically binding to abeta oligomer, and use thereof
ES2617604T3 (es) * 2008-02-08 2017-06-19 Immunas Pharma, Inc. Anticuerpos capaces de unirse específicamente a oligómeros de beta amiloides, y su utilización
US20110189093A1 (en) * 2008-04-14 2011-08-04 Proscan Rx Pharma Prostate specific membrane antigen antibodies and antigen binding fragments
US9085614B2 (en) 2008-08-01 2015-07-21 Immunas Pharma, Inc. Antibodies that specifically bind to Aβ oligomers and uses thereof
WO2010020593A1 (en) * 2008-08-18 2010-02-25 Glaxo Group Limited Treatment of an autoimmune disease using il-18 antagonists
WO2010040736A2 (en) * 2008-10-07 2010-04-15 Ablynx Nv Amino acid sequences directed against il18 and/or the il-18 receptor and polypeptides comprising the same for the treatment of diseases and/or disorders associated with il-18 mediated signaling
US8168165B2 (en) * 2008-12-23 2012-05-01 Abbott Laboratories Alkylated interleukin-18 compositions
EP2419447B1 (de) 2009-04-17 2017-08-23 Immunas Pharma, Inc. Spezifisch an abeta-oligmomere bindende antikörper und ihre verwendung
WO2011001805A1 (ja) * 2009-06-30 2011-01-06 株式会社ゴーセン ラケット用ストリングとその製造方法及びこれを張設したラケット
CN102574915B (zh) 2009-08-06 2014-10-22 伊缪纳斯制药株式会社 特异性结合Aβ寡聚体的抗体及其用途
ES2614949T3 (es) 2009-08-06 2017-06-02 Immunas Pharma, Inc. Anticuerpos que se unen específicamente a oligómeros beta A y uso de los mismos
WO2011025964A2 (en) 2009-08-29 2011-03-03 Abbott Laboratories Therapeutic dll4 binding proteins
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
KR20120133382A (ko) * 2010-02-09 2012-12-10 글락소 그룹 리미티드 대사 장애의 치료
WO2011106697A1 (en) 2010-02-25 2011-09-01 Schepens Eye Research Institute Therapeutic compositions for the treatment of dry eye disease
RU2016146198A (ru) * 2010-03-02 2018-12-19 Эббви Инк. Терапевтические dll4-связывающие белки
US20130109107A1 (en) * 2010-05-25 2013-05-02 The Regents Of The University Of Colorado Diagnosis and treatment of autoimmune disease
AU2011282536B2 (en) 2010-07-30 2015-12-24 Ac Immune S.A. Safe and functional humanized anti beta-amyloid antibody
RU2013133846A (ru) 2010-12-20 2015-01-27 Медиммьюн Лимитед Антитела против il-18 и их применение
JOP20200308A1 (ar) 2012-09-07 2017-06-16 Novartis Ag جزيئات إرتباط il-18
WO2014080866A1 (ja) 2012-11-21 2014-05-30 一般財団法人化学及血清療法研究所 新規なヒト抗ｉｌ－１８抗体
CN107660150B (zh) * 2015-03-05 2023-10-24 Ab2生物股份有限公司 Il-18结合蛋白(il-18bp)和抗体在炎性疾病中
CA3183242A1 (en) * 2020-06-18 2021-12-23 Dallas Benjamin Flies Compositions and methods for modulating flrt3 mediated signal transduction
EP4371573A1 (de) 2021-07-13 2024-05-22 National University Corporation Tokai National Higher Education and Research System Medizinische zusammensetzung zur behandlung von entzündlicher darmerkrankung
CN117986360B (zh) * 2024-02-01 2024-08-27 生物岛实验室 Il18蛋白的特异性抗体及其制备方法与应用

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CA2276216A1 (en) 1998-06-24 1999-12-24 Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo An artificial peptide capable of neutralizing the biological activity of interleukin-18
AR022952A1 (es) * 1999-03-19 2002-09-04 Smithkline Beecham Corp ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL

Also Published As

Publication number Publication date
CA2368965C (en) 2010-05-18
AR022952A1 (es) 2002-09-04
HK1043798B (zh) 2009-04-09
EP1163271A1 (de) 2001-12-19
CA2368965A1 (en) 2000-09-28
ZA200107639B (en) 2002-09-17
US20040141964A1 (en) 2004-07-22
MY124219A (en) 2006-06-30
KR20020008130A (ko) 2002-01-29
PT1163271E (pt) 2008-09-16
CO5470287A1 (es) 2004-12-30
EP1163271A4 (de) 2003-04-09
EP1163271B1 (de) 2008-07-23
WO2000056771A1 (en) 2000-09-28
CN1246335C (zh) 2006-03-22
US6706487B1 (en) 2004-03-16
TR200202254T2 (tr) 2002-12-23
JP2002542769A (ja) 2002-12-17
CZ20013362A3 (cs) 2002-03-13
BR0008688A (pt) 2002-01-08
EP1961768A1 (de) 2008-08-27
NO20014524L (no) 2001-11-14
PL202396B1 (pl) 2009-06-30
IL144995A0 (en) 2002-06-30
TR200102733T2 (tr) 2002-04-22
PL350460A1 (en) 2002-12-16
HUP0200502A2 (en) 2002-06-29
HUP0200502A3 (en) 2003-12-29
SI1163271T1 (sl) 2008-10-31
AU764622B2 (en) 2003-08-28
CY1108387T1 (el) 2014-02-12
NO20014524D0 (no) 2001-09-18
HU228931B1 (en) 2013-06-28
CZ303704B6 (cs) 2013-03-27
ATE402191T1 (de) 2008-08-15
AU3901600A (en) 2000-10-09
KR100697120B1 (ko) 2007-03-20
NZ513699A (en) 2004-02-27
HK1043798A1 (en) 2002-09-27
DK1163271T3 (da) 2008-11-10
NO330391B1 (no) 2011-04-04
TR200202253T2 (tr) 2002-12-23
CN1352650A (zh) 2002-06-05
ES2308974T3 (es) 2008-12-16

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